Pectorin Tablet 80 mg (Febuxostat)

Adult dosage

40mg or 80mg once daily Recheck the serum uric acid concentration after 2 weeks. The treatment goal is to lower and maintain the serum uric acid concentration below 6 mg/dL(357 μmol/L). No dose adjustment is necessary in patients with mild or moderate renal impairment. The safety and efficacy of this medicine have not been adequately evaluated in patients with severe renal impairment (creatinine clearance below 30mL/min). No specific dose adjustment is necessary in patients with mild or moderate hepatic impairment. Only limited information is available for patients with moderate hepatic impairment, and the efficacy and safety of this medicine have not been studied in patients with severe hepatic impairment (Child-Pugh class C).

This medication may increase the risk of cardiovascular mortality in gout patients with cardiovascular disease, so patients with a history of cardiovascular disease should consult a doctor before using this medication. Patients with allergies to the active ingredient or excipients, those taking specific medications (mercaptopurine, azathioprine), and patients with lactose intolerance or related genetic problems should not take this medication. Patients with a history of liver disease or thyroid dysfunction should regularly monitor liver and thyroid function tests while using this medication, and caution is also required in patients with heart disease or heart failure. When taken with theophylline, caution is advised due to the potential accumulation of metabolic products in the body, and patients with a history of organ transplantation or cardiovascular disease should also be administered this drug carefully. During the use of this medication, there may be side effects such as liver dysfunction, skin rash, indigestion, headache, fatigue, and dizziness; if any abnormal symptoms occur, it is important to consult a doctor immediately. Do not start this medication during acute gout attacks, and do not discontinue it even if a gout attack occurs; continue using it while managing the attack appropriately. This medication may interact with specific drugs, so if you are taking other medications, be sure to inform your healthcare provider. Pregnant or nursing women should avoid using this medication, and it is not recommended for use in children under 18 years of age. There is no need for special dosage adjustments for the elderly; however, sensitivity may vary by individual, so caution is warranted. In case of overdose, there is no specific antidote, and treatment and supportive therapy should be provided according to symptoms. Keep this medication out of reach of children, and no special storage conditions are required.

Liver dysfunction, dizziness, diarrhea, headache, rash, nausea, fatigue, arthralgia, limb pain, gout, myalgia, pruritus, dyspnea, anemia, idiopathic thrombocytopenic purpura, leukocytosis, leukopenia, neutropenia, pancytopenia, splenomegaly, thrombocytopenia, angina pectoris, atrial fibrillation, atrial flutter, heart murmur, electrocardiogram abnormalities, palpitations, bradycardia, tachycardia, hearing loss, tinnitus, vertigo, blurred vision, abdominal distension, abdominal pain, constipation, dry mouth, dyspepsia, bloating, increased bowel movement frequency, gastritis, gastroesophageal reflux disease, gastrointestinal discomfort, gum pain, hematemesis, hyperchlorhydria, passage of blood in stool, oral ulcer, pancreatitis, gastric ulcer, vomiting, asthenia, chest pain, chest discomfort, edema, emotional disturbances, gait disorders, influenza-like symptoms, mass, pain, thirst, cholelithiasis, diabetes mellitus, fatty liver, hepatitis, hepatomegaly, hypersensitivity, herpes zoster, anorexia, decreased appetite, increased appetite, dehydration, diabetes, hypercholesterolemia, hyperlipidemia, hypertriglyceridemia, hypokalemia, weight loss, weight gain, arthritis, joint stiffness, joint swelling, muscle cramps, muscle single contraction, muscle constriction, muscle weakness, musculoskeletal pain, muscle rigidity, taste changes, balance disorders, cerebrovascular accident, Guillain-Barré syndrome, headache, partial paralysis, sensory loss, hyposmia, heat stroke, drowsiness, mental disorder, migraine, sensory disturbances, somnolence, transient ischemic attack, tremors, agitation, anxiety, depression, insomnia, excitability, decreased libido, irritability, panic attack, personality changes, hematuria, nephrolithiasis, frequent urination, proteinuria, renal failure, impaired renal function, urinary urgency, urinary incontinence, breast pain, erectile dysfunction, gynecomastia, bronchitis, cough, dyspnea, epistaxis, nasal dryness, excessive sinus secretion, pharyngeal edema, airway congestion, sneezing, throat irritation, upper respiratory infection, alopecia, angioedema, dermatitis, skin rash, petechiae, eczema, hair discoloration, abnormal hair growth, hyperhidrosis, skin peeling, petechiae, photosensitivity, pruritus, purpura, skin discoloration, changes in skin pigmentation, skin lesions, axillary osmidrosis, urticaria, flushing, facial flushing, hypertension, hypotension, activated partial thromboplastin time prolongation, creatinine increase, bicarbonate decrease, sodium increase, EEG abnormalities, glucose increase, cholesterol increase, triglyceride increase, amylase increase, potassium increase, thyroid-stimulating hormone increase, platelet decrease, hematocrit decrease, hemoglobin decrease, MCV increase, erythrocyte decrease, creatinine increase, blood urea increase, blood urea to creatinine ratio increase, CPK increase, ALP increase, LDH increase, PSA increase, urinary output increase, urinary output decrease, lymphocyte count decrease, neutrophil count decrease, white blood cell count increase, white blood cell count decrease, blood coagulation test abnormalities, low-density lipoprotein increase, prothrombin time prolongation, urinary casts, positive urinary leukocytes, positive urinary protein, bruising, Stevens-Johnson syndrome, toxic epidermal necrolysis, acute anaphylactic reactions, shock, liver failure, jaundice, angioedema, agranulocytosis, rhabdomyolysis

This medication should be stored in a tightly closed container to prevent exposure to air or moisture. It is important to maintain a storage temperature between 1 and 30 degrees Celsius. Doing so will help preserve the efficacy and safety of the medication over time.

Appearance

Pale yellow to yellow oblong film-coated tablets

Package unit

Domestic - 30 tablets/bottle, Domestic - 100 tablets/bottle