Linagliptin/Metformin Duo Tablet 2.5/500mg

Adult dose

This medication is administered twice daily with meals. 1. If currently not being treated with metformin: Take this medication 2.5/500 mg twice daily, 1 tablet at a time, and can increase to 2.5/1000 mg twice daily, 1 tablet at a time. 2. For conversion from linagliptin and metformin combination therapy: Initially take the same dose as linagliptin and metformin previously used.

This medication can cause a serious metabolic complication called lactic acidosis, so it should not be administered to patients at high risk for lactic acidosis. This medication contains linagliptin and metformin, so it should not be used in patients who are allergic to these ingredients or who have certain conditions (e.g., type 1 diabetes, lactic acidosis, severe renal impairment, severe liver dysfunction). Patients with impaired renal function should undergo renal function tests before using this medication, and it should not be administered if renal function is below a certain level. When using this medication, hypoglycemic symptoms may occur, especially when taken with other glucose-lowering agents such as sulfonylureas or insulin, so caution is advised. This medication should be discontinued in acute conditions such as acute heart failure, acute myocardial infarction, or severe infections, and can be resumed once the condition stabilizes. If skin adverse reactions such as acute pancreatitis or bullous pemphigoid occur, stop taking this medication immediately and consult healthcare providers. This medication may lower vitamin B12 levels, so it is advisable to regularly check for vitamin B12 deficiency if taken for a long time. It is not safe for women who are pregnant or may be pregnant, or for nursing mothers to use this medication. Elderly patients may commonly have reduced renal function, so renal function should be regularly monitored, and the dosage adjusted when administering this medication. This medication may interact with various drugs, so inform the doctor or pharmacist if taking other medications. Avoid excessive alcohol consumption while taking this medication, and immediately report to healthcare providers if severe dehydration, vomiting, diarrhea, or similar symptoms occur, and consider stopping the medication. This medication can be taken without regard to meals, but for reducing gastrointestinal discomfort, it is recommended to take it during or after meals. There is a risk of lactic acidosis from overdose, so it is essential to adhere strictly to the prescribed dosage, and to visit a hospital immediately if any unusual symptoms occur.

Serious side effects

Urticaria, severe swelling (angioedema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with fever, blistering, skin peeling, pain in oral/ocular mucosa, shortness of breath or difficulty breathing, asthma attack, respiratory distress accompanied by cough and fever, jaundice (yellowing of the skin or eyes), extreme lethargy, sudden and severe headaches, thunderclap headache, seizures, disorientation, visual disturbances, paralysis,

Mild side effects

• Nasopharyngitis
• hypersensitivity
• hypoglycemia
• taste disorder
• cough
• reduced appetite
• diarrhea
• constipation
• nausea
• vomiting

This medication is sensitive to air and moisture, so it should be stored in a tightly closed container. It is best to store it at room temperature between 1 to 30 degrees Celsius.

Appearance

Bright yellow, biconvex oval film-coated tablet

Package unit

10 tablets/PTP [(10 tablets/PTP packaging x 6)], 6 PTPs/box