Ogume Tablet 375 mg (Amoxicillin-Potassium Clavulanate)

Adult dose

Adults and children aged 12 years and older or weighing 40 kg or more should take amoxicillin/potassium clavulanate at a dose of 250 mg/125 mg orally three times a day, every 8 hours. In cases of severe respiratory infections, the dose may be increased to 500 mg/125 mg. Patients with renal impairment should adjust the dosage according to creatinine clearance. - Creatinine clearance over 30 mL/min: No dosage adjustment needed - 1

Child dose

In children under 12 years of age or those weighing less than 40 kg, the dosage should be adjusted accordingly.

This medication should not be used in specific patients. Individuals who have experienced allergies to the ingredients of this medication or to beta-lactam antibiotics may experience serious allergic reactions if they take this medication and should avoid it. Additionally, it is advisable not to use this medication in patients with concurrent viral infections such as infectious mononucleosis or lymphocytic leukemia due to the increased risk of side effects such as rashes. Patients who have previously experienced liver dysfunction or jaundice from this medication or penicillin-based drugs may also have recurring symptoms if taking this medication, and caution is required. Patients with poor liver function or severe kidney disease should use this medication carefully, as liver and kidney functions may deteriorate further. Additionally, those with family members who have asthma or allergic symptoms may have a higher likelihood of experiencing allergic reactions when taking this drug. Patients who have difficulty with oral intake, elderly individuals, or those in a poor overall condition must be monitored for the risk of bleeding due to vitamin K deficiency. Patients with significant gastrointestinal diseases resulting in severe vomiting or diarrhea may have poor absorption of the medication, requiring caution. Taking this medication may cause various gastrointestinal symptoms such as diarrhea, dyspepsia, vomiting, and abdominal pain. If severe diarrhea or abdominal pain occurs, the medication should be discontinued, and a doctor should be consulted. Abnormal liver function has also been reported, particularly more frequently in the elderly or in males, so regular liver function tests are advisable. Symptoms such as itching or rashes may occur on the skin, and in severe cases, serious skin reactions like Stevens-Johnson syndrome can develop, necessitating immediate cessation of the medication if symptoms occur. Changes such as leukopenia or thrombocytopenia may rarely be seen in blood tests, and neurological symptoms may include anxiety, drowsiness, headache, and, rarely, seizures. Kidney function impairment may also develop, so it is important to regularly monitor kidney function. Fungal infections such as oral candidiasis may occur, necessitating appropriate treatment if symptoms present. This medication may interact with other drugs, so caution is necessary, particularly when taken with anticoagulants, gout medications, and other antibiotics. It may reduce the effectiveness of oral contraceptives, so women taking them should consider additional contraceptive methods. It is advisable to avoid its use during pregnancy, except in specific circumstances, and breastfeeding women should be cautious, as this medication may be passed into breast milk, potentially causing side effects in the infant. Experience with use in children under the age of 12 is limited, and it is not recommended for this age group. The elderly are at increased risk of medication side effects due to impaired kidney and liver function and should be closely monitored. During treatment with this medication, it is advisable to inform the doctor about potential effects on some clinical test results, such as urine tests. In the case of overdose, symptoms such as vomiting, diarrhea, rash, drowsiness, and seizures may occur, and immediate discontinuation of the medication and consultation with medical personnel is necessary.

Serious side effects

Urticaria, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, skin peeling, pain in oral/ocular mucosa, shortness of breath or difficulty breathing, asthma attack, respiratory issues accompanying cough and fever, jaundice (yellowing of skin or eyes), profound fatigue, sudden and severe headaches, thunderclap headaches, seizures, confusion, visual disturbances, paralysis, urination changes

Mild side effects

• Diarrhea
• pseudomembranous colitis
• dyspepsia
• stomatitis
• gastritis
• glossitis
• nausea
• vomiting
• loss of appetite
• abdominal pain

This medication should be kept in a sealed container to avoid moisture and stored at a cool temperature between 1 and 25 degrees Celsius. It is important to avoid direct sunlight and not to place it in excessively hot or cold areas.

Appearance

White or almost white oval film-coated tablet

Package unit

100 tablets/box [10 tablets/PTP × 10]