Ibupen Injection (Ibuprofen)

Adult dosage

For control of moderate to severe pain, intravenous administration of 400 mg-800 mg as needed every 6 hours. A maximum of 3200 mg can be administered per day, with administration time exceeding 30 minutes. For fever, intravenous administration of 400 mg as needed every 4-6 hours. Depending on the patient's condition, after an initial dose of 400 mg, 100-200 mg may be administered every 4 hours.

Children's dosage

For children over 6 months to under 12 years, for fever, intravenous administration of 10 mg/kg (maximum 400 mg) as needed every 4 to 6 hours, with administration time exceeding 10 minutes. Maximum 40 mg/kg or 2,400 mg per day.

This medication may cause serious cardiovascular problems such as myocardial infarction and stroke in patients with cardiovascular diseases or risk factors. This medication may produce serious gastrointestinal issues such as gastrointestinal bleeding, ulcers, and perforations, especially in elderly patients or those on long-term medication. Patients with a history of gastrointestinal ulcers or bleeding, severe blood, liver, kidney, or heart dysfunction, and those allergic to the ingredients of this medication should not take it. Patients with bronchial asthma or those who have had hypersensitivity reactions to aspirin or other non-steroidal anti-inflammatory drugs should also avoid this medication. This medication should not be taken during late pregnancy due to the risk of early closure of the fetal ductus arteriosus. Caution should be exercised in patients with blood disorders, liver or kidney diseases, heart failure, hypertension, autoimmune diseases, ulcerative colitis, Crohn's disease, the elderly, pregnant women, and nursing mothers. Patients taking low-dose aspirin should be cautious as this medication may reduce the cardioprotective effect of aspirin and increase the risk of gastrointestinal bleeding. Various serious side effects such as shock, blood disorders, gastrointestinal bleeding, skin rashes, liver dysfunction, respiratory distress, visual disturbances, neurological changes, and kidney function abnormalities may occur during the use of this medication, so you should immediately consult a healthcare provider if any abnormal symptoms arise. Do not exceed the recommended dosage during administration, and it is advisable not to take it in conjunction with other non-steroidal anti-inflammatory drugs. Patients with hypertension should frequently check their blood pressure before and after taking this medication, and those with heart failure or edema should be cautious as fluid retention may worsen. Patients with impaired kidney function or signs of dehydration may have a risk of kidney damage when taking this medication, so follow your physician's instructions. If there are signs of liver dysfunction, consideration should be given to discontinuing the administration, and it is advisable to check for anemia through blood tests. Severe allergic reactions such as anaphylaxis may occur, so seek immediate treatment if hypersensitivity is suspected. This medication can cause severe skin reactions; thus, if there are skin rashes or allergic reactions, it should be discontinued immediately. If there are signs of infection, caution is needed as the antipyretic and anti-inflammatory effects of this medication can mask symptoms. Asthma patients should be cautious when using this medication due to the possibility of cross-reactivity with aspirin-sensitive asthma. If visual disturbances occur, such as blurred vision or a decrease in vision, you must stop taking the medication immediately and undergo an ophthalmological examination. If aseptic meningitis symptoms manifest, evaluate the relationship with this medication and take appropriate action. This medication may interact with other drugs, especially with aspirin, anticoagulants, ACE inhibitors, diuretics, lithium, methotrexate, and selective serotonin reuptake inhibitors, so consult your doctor. Particularly after the 20th week of pregnancy, there is a risk of fetal renal dysfunction and oligohydramnios, so it is recommended to use the lowest dose for the shortest duration, and it should not be taken after the 30th week of pregnancy. During lactation, this medication can be transmitted through breast milk and may cause adverse reactions in infants, so it is preferable to either discontinue breastfeeding or stop taking the medication. The safety and efficacy in children under 6 months have not been established, so it is advisable not to use this medication. Elderly patients may have decreased physical function, requiring dose adjustments and close monitoring. In case of overdose, serious symptoms such as dizziness, nausea, vomiting, liver dysfunction, kidney failure, respiratory distress, and hypotension may occur, so stop taking the medication immediately and seek emergency treatment.

Serious side effects

Hives, severe swelling (including angioedema, periorbital edema, facial edema), chest tightness, difficulty breathing, anaphylactic reaction, asthma attack, respiratory distress, shock, hypotension, hypertension, myocardial infarction, stroke, heart failure, blood disorders (aplastic anemia, hemolytic anemia, agranulocytosis, granulocytopenia, leukopenia, thrombocytopenia, platelet dysfunction, blood disorders), severe skin abnormalities

Mild side effects

• Nausea
• vomiting
• bloating
• headache
• diarrhea
• drowsiness
• dizziness
• depression
• dyspepsia
• abdominal discomfort

Store this medication in a sealed container to prevent air ingress, preferably at room temperature between 1 and 30 degrees Celsius. Storing it this way will help maintain the medication's efficacy for an extended period.

Appearance

A colorless or pale yellow transparent injection solution contained in a colorless transparent glass vial.

Package unit

4 mL/vial [X 10 vials], 8 mL/vial [X 10 vials]