Kaysillin Tablets 625 mg (Amoxicillin-Potassium Clavulanate)

Adult dose

For adults and children 12 years or older or weighing 40 kg or more, the medication should be administered orally as amoxicillin/potassium clavulanate at a dosage of 250 mg/125 mg three times a day every 8 hours. In cases of severe respiratory infections, the dosage can be increased to 500 mg/125 mg once. Dosage adjustments should be based on creatinine clearance for patients with renal impairment. - Creatinine clearance greater than 30 mL/min: No dosage adjustment needed.

Child dose

Children under 12 years of age or weighing less than 40 kg should receive a reduced dosage based on renal function similar to adults.

This drug, being a beta-lactam antibiotic, should not be administered to patients with a history of hypersensitivity to penicillin and cephalosporin. Patients with infectious mononucleosis or lymphocytic leukemia are at higher risk of rashes and should be monitored closely. Patients with a history of liver dysfunction or jaundice due to this drug or penicillin drugs should not use it. Patients with impaired liver function or moderate to severe renal impairment should use it with caution and adjust the dosage interval as drug concentration may increase. Patients with allergic tendencies or those with symptoms such as bronchial asthma or urticaria should also be cautious. Elderly patients and those in poor general health are at risk for bleeding due to vitamin K deficiency and should be monitored. This medication may cause gastrointestinal side effects such as diarrhea, vomiting, and abdominal pain; it must be discontinued immediately if severe symptoms occur. Liver function abnormalities may also occur, particularly in men over 60, necessitating regular liver function tests. Severe skin reactions such as rashes, itching, and in severe cases, Stevens-Johnson syndrome may occur, requiring immediate consultation with a healthcare provider. Blood disorders such as leukopenia and thrombocytopenia may rarely develop, warranting blood monitoring. Central nervous system reactions including anxiety, confusion, and seizures have been reported, thus caution is needed in patients with renal impairment or those on high doses. Acute renal failure or nephritis may occur, so if symptoms of renal dysfunction appear, administration must be halted immediately. This medication can cause vitamin K deficiency symptoms, thus patients with bleeding tendencies should be cautious and those on anticoagulants should monitor coagulation status regularly. It should be avoided in the first three months of pregnancy, and pregnant or nursing women should use it cautiously after consulting a doctor. It is not recommended for children under 12 years of age or weighing less than 40 kg, as there is limited experience. Due to many drug interactions, patients should consult with a doctor or pharmacist when taking this drug with others, particularly anticoagulants, gout medication, and antibiotics. Overdose may lead to gastrointestinal symptoms, kidney issues, or central nervous system abnormalities, thus immediate medical attention should be sought.

Serious side effects

Urticaria, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, skin peeling, pain in mucous membranes of mouth/eyes, yellowing of skin or eyes (jaundice), feeling very lethargic, sudden and severe headache, lightning headache, seizures, confusion, visual abnormalities, paralysis, significant decrease in urine output, severe swelling and increased blood pressure, anaphylaxis, bleeding

Mild side effects

Diarrhea, indigestion, stomatitis, gastritis, glossitis, nausea, vomiting, loss of appetite, abdominal pain, bloating, constipation, colonic pain, hyperacidity, loose stools, dry mouth, acute pancreatitis, candidiasis, colitis with blood-stained stools, elevated AST, ALT, ALP, LDH, serum bilirubin, hepatitis, itching, multiforme exudative erythema, mucocutaneous syndrome, toxic epidermal necrolysis, vesicular exfoliative dermatitis, acute generalized exanthematous pustulosis, eosinophilia

This medication should be stored in a sealed container to prevent moisture and kept at a cool temperature between 1 and 25 degrees Celsius. This storage method helps maintain the effectiveness and safe use of the drug.

Appearance

White or almost white oval film-coated tablets

Package unit

40 tablets/PTP [(4 tablets/PTP*10)]