Phenorix EH Tablets (Fenofibric Acid)

Adult dose

As fenofibric acid, take 110 mg (1 tablet) orally once daily, ensuring dietary therapy is implemented alongside. This medication can be taken regardless of meals.

This medication should not be used in patients with severe liver dysfunction or gallbladder disease. Furthermore, patients with severe kidney dysfunction, pregnant women or women of childbearing potential, and nursing mothers should also avoid this medication. Patients with a known allergy to this medication should avoid administration, and since it contains lactose, it should not be used in patients who are lactose intolerant or have certain genetic metabolic disorders. Caution should be exercised when administering this medication to patients with kidney or liver issues, hypoalbuminemia, or children. This medication may affect liver function, which could lead to elevated liver enzyme levels or conditions such as cholelithiasis or hepatitis, thus regular liver function tests are essential. Rarely, skin adverse reactions like itching, rashes, and hair loss may occur, alongside neurological symptoms such as dizziness, headaches, and weakness. Musculoskeletal adverse reactions like myalgia or muscle cramps may also manifest, particularly in patients with poor kidney function, where there is a risk of muscle damage and kidney worsening. Various side effects such as photosensitivity dermatitis, gastrointestinal disorders, blood abnormalities, impaired kidney function, fatigue, pneumonia, and arrhythmia have been reported; hence any unusual symptoms should be promptly discussed with a healthcare professional. Patients with weakened kidney function must undergo regular kidney function tests before and during treatment, and dosage adjustments or intervals may be necessary. Before administration, it is advisable to confirm the presence of hyperlipidemia and ensure sufficient non-drug treatments, such as diet and exercise therapy, have been implemented prior to using this medication. While taking this medication, regular checks of blood lipid levels are recommended; if there is no therapeutic effect, discontinuation should be considered. Acute hypersensitivity reactions or severe skin side effects may occur; if any symptoms arise, immediate discontinuation of the medication and professional evaluation are necessary. There are many drug interactions, especially with statins, anticoagulants, hypoglycemics, uric acid treatments, and oral contraceptives, therefore caution is warranted when using these in conjunction. It should not be used with drugs that have a risk of hepatotoxicity, and kidney function should be closely monitored in organ transplant patients. Pregnant or nursing women should not take this medication as it may pose risks to the fetus or newborn. Caution is required when administering to children, as urinary difficulties may occur. Elderly patients may commonly experience decreased liver and kidney function, necessitating heightened caution during administration and regular monitoring of blood creatinine levels. Additionally, there is a risk of hypoglycemia when taken with certain hypoglycemics in the elderly, so caution is required. No specific antidote is available in case of overdose, and blood dialysis does not remove the drug, therefore careful management is necessary.

Serious side effects

Acute hypersensitivity reactions (anaphylaxis and angioedema), severe skin reactions (SCAR), DRESS syndrome, rhabdomyolysis, rapid deterioration of kidney function, reversible kidney damage associated with elevated serum creatinine levels, urinary difficulties

Mild side effects

• Elevated transaminase levels
• cholelithiasis
• rarely hepatomegaly
• pruritus
• skin rash
• hair loss
• dizziness
• headache
• weakness
• fever

This medication should be stored in a tightly sealed container to prevent air or moisture penetration, preferably at room temperature between 1 to 30 degrees Celsius. This storage method helps maintain the effectiveness of the medication and prevents deterioration.

Appearance

White, round enteric-coated film-coated tablet

Package unit

30 tablets per bottle