Hyalex Injection (Sodium Hyaluronate)

Adult dosage

As sodium hyaluronate, administer 25mg once a week for 5 consecutive weeks into the intra-articular space of the knee or shoulder (shoulder joint space, subacromial bursa, or biceps tendon sheath). The number of administrations may be adjusted according to symptoms. As it is administered into the knee joint, it should be performed under strict aseptic conditions.

This medication should not be used in patients who have had an allergic reaction to this drug or its components. As it is administered by direct injection into the joint, it should not be given if there are skin diseases or infections at the injection site. Caution is required for patients with liver dysfunction, as abnormal liver function tests may occur. It is also safe to avoid use in individuals with allergies to avian protein. Severe allergic reactions, such as shock, may occur after administration, so patients should be closely monitored, and if any unusual symptoms appear, administration should be stopped immediately, and appropriate treatment should be provided. Swelling, redness, itching, and rashes may occur around the face or eyes, so if these symptoms are observed, use of the medication should be stopped, and medical assistance should be sought. Temporary pain, swelling, redness, warmth, or tenderness may occur at the injection site. Sometimes symptoms such as nausea, vomiting, fever, or headaches may also occur. For patients with severe inflammatory osteoarthritis, it is advisable to use this medication after the inflammation has subsided, and stabilization of the injection site is necessary post-administration. If the drug leaks outside the joint, it may cause pain, so it is important to inject it accurately within the joint. Patients with rheumatoid arthritis or gouty arthritis should take care as inflammation may temporarily worsen. It is recommended to avoid vigorous exercise or prolonged weight-bearing activities within 48 hours following the injection. Use with other intra-articular injectables is not recommended as safety and efficacy have not been confirmed. Women who are pregnant or may become pregnant should use this medication cautiously as its safety is not well established and only if necessary. Additionally, this medication may be transmitted through breast milk, so breastfeeding should be avoided during administration. Safety has not been established in children, so caution should be exercised and should only be used when necessary. Elderly patients should use this medication carefully as their body functions may be weakened. Injections must be administered strictly into the joint under aseptic conditions, and if symptoms do not improve, administration may be repeated up to five times. If fluid accumulates in the joint, it may need to be drained as needed. This drug should not be used for intra-vascular injection or ophthalmic purposes. Due to its high viscosity, care should be taken in selecting syringes and needles, and after shaking the ampoule to ensure even distribution of the medication, it should be slowly drawn into the syringe. When opening the ampoule, it is advisable to clean and cut it carefully to prevent contamination. Care should be taken as some disinfectants may react and form precipitates. This drug is for single use and any remaining medication should be discarded after opening. Administering a local anesthetic before this medication can aid in pain relief.

Serious side effects

• Hives
• swelling (facial, eyelid, etc.)
• shock

Mild side effects

• Facial erythema
• itching
• short-term pain at the injection site
• swelling
• redness
• warmth
• local tenderness
• petechiae
• nausea
• vomiting

Prefilled syringes are contained in sealed containers, and should be stored at a temperature between 1°C and 30°C to maintain the medication's effectiveness safely.

Appearance

A colorless and transparent viscous liquid filled in a glass vial sealed with rubber stoppers at both ends (part of a prefilled syringe system)

Package unit

2.5 milliliters/ampoule [2.5 milliliters × 10, 50, 100 ampoules], 2.5 milliliters/cylinder [2.5 milliliters × 10, 50, 100 cylinders]