DobiPri Tablet 1mg (Varenicline Salicylate)

Adult dose

After setting a quit date, patients should start taking Smoex 1 week before that date. Alternatively, they may begin smoking cessation between day 8 and day 35 after starting this medicine. This medicine should be taken after meals with plenty of water. The recommended dosage of Smoex is as follows: after dose titration over 1 week, take 1 mg twice daily. Days 1–3 0.5 mg once daily Days 4–7 0.5 mg twice daily Day 8 until the end of treatment 1 mg twice daily For patients who cannot tolerate the adverse reactions of Smoex tablets, the dose may be reduced temporarily or permanently. Smoex should be administered for 12 weeks. For patients who have successfully quit smoking after the initial 12 weeks of treatment, an additional 12 weeks of Smoex is recommended to increase the likelihood of long-term abstinence. For patients who cannot or do not wish to stop smoking abruptly, gradual smoking cessation while taking this medicine should be considered. The amount smoked should be reduced by 50% from the pretreatment level within the first 4 weeks after starting treatment, and by a further 50% over the next 4 weeks. Smoking should then be reduced continuously, with complete cessation achieved by week 12. Continue this medicine for an additional 12 weeks, for a total treatment duration of 24 weeks. Encourage patients to stop smoking sooner if they feel ready. For patients who fail to quit smoking during the initial 12 weeks of treatment or resume smoking after treatment, review the reasons for failure before trying again. However, there are no data demonstrating the efficacy of an additional 12 weeks of treatment in patients who failed to quit during the initial 12 weeks or resumed smoking after treatment. No dose adjustment is necessary in patients with mild (estimated creatinine clearance > 50 mL/min and ≤ 80 mL/min) to moderate (estimated creatinine clearance ≥ 30 mL/min and ≤ 50 mL/min) renal impairment. In patients with severe renal impairment (estimated creatinine clearance < 30 mL/min), the recommended starting dose of Smoex is 0.5 mg once daily. If needed, the maximum dose is 0.5 mg twice daily. In patients with end-stage renal disease undergoing hemodialysis, if well tolerated, a maximum dose of 0.5 mg once daily may be administered. No dose adjustment is necessary in patients with hepatic impairment. Since renal function is more likely to be reduced in elderly patients, care should be taken when selecting the dose, and monitoring renal function may be useful.

Child dose

Use in patients under 18 years of age is not recommended because the safety and efficacy of Smoex have not been established in children.

This medication is used to assist with quitting smoking. Psychological changes such as depression, anxiety, and suicidal thoughts may occur during treatment, so mental status should be carefully monitored. If there is a history of psychiatric conditions, it must be reported to the physician, and if unusual symptoms appear, usage should be stopped immediately and consultation sought. This medication should not be administered to individuals with allergic reactions or hypersensitivity to its components. Women who are pregnant or breastfeeding should use it cautiously after consulting a doctor. Common side effects include nausea, headaches, insomnia, and unusual dreams. Rarely, there may be occurrences of angioedema, severe skin reactions, and cardiovascular issues, so any symptoms that arise should be reported to a physician immediately. Caution is advised while driving or operating machinery, as drowsiness and dizziness may occur. There is minimal interaction with other medications, but alcohol consumption should be minimized or avoided. Elderly patients with decreased kidney function may require dosage adjustment based on doctor's instructions. In case of overdose, immediate medical attention should be sought. Keep out of reach of children and store in the original container.

• Suicidal thoughts
• suicidal behavior
• suicide
• changes in behavior or thoughts
• depression
• mania
• mood changes
• psychosis
• aggressive behavior
• hallucinations

This medication must be stored in a tightly sealed container to protect it from air and moisture. For best results, store the medication at room temperature between 1°C and 30°C. Avoid places that are too cold or too hot.

Appearance

Light blue, convex, rectangular film-coated tablet on both sides.

Package unit

28 tablets/box [(14 tablets/Blister × 2)]