Erostin Tablet 5 milligrams (Rosuvastatin Calcium)

Adult dosage

Administer 5 milligrams once daily as the initial dose at any time of the day, regardless of meals. If more LDL-cholesterol reduction is needed, adjust the maintenance dose to 10 milligrams once daily, and the dose can be increased to a maximum of 20 milligrams once daily based on the patient's response, at intervals of 4 weeks or more.

Children's dosage

Pediatric patients aged 10 to 17 years with heterozygous familial hypercholesterolemia should be given a dose of 5 milligrams to 20 milligrams once a day. Dosages should be adjusted according to treatment goals at intervals of 4 weeks or more.

This medication should not be administered to specific patients. For example, patients with an allergy to this medication or severely impaired liver function, those with muscle disorders, patients with severely impaired kidney function, and women who are pregnant or nursing should not take this medication. Additionally, high-dose use of this medication is contraindicated in patients at risk for muscle disorders or those with specific genetic traits. Since this medication contains lactose, patients with lactose intolerance should not take it. Patients with liver function issues or those who consume excessive alcohol should undergo repeated liver function tests before and during the use of this medication, and those with hypothyroidism should receive treatment prior to starting this medication. This medication may cause muscle-related side effects, including muscle pain, muscle weakness, and in severe cases, rhabdomyolysis due to muscle cell destruction, so any symptoms of muscle pain or weakness should be reported to a doctor immediately. Patients at high risk of muscle damage should have muscle enzyme levels checked before and during treatment. This medication can rarely cause serious skin reactions or liver damage, so if symptoms such as rash, jaundice, or extreme fatigue occur, treatment should be discontinued immediately and medical advice should be sought. When taken with other medications, interactions may occur, particularly when combined with specific antiviral agents, immunosuppressants, antibiotics, fibrate-class drugs, etc. Some medications can increase the blood concentration of this drug, raising the risk of side effects. Women who are pregnant or may become pregnant must have adequate contraception and should discontinue use immediately if pregnancy occurs. It is also advisable for nursing mothers not to take this medication. In the case of overdose, there is no specific antidote, so symptomatic treatment and monitoring of liver function and muscle enzyme levels are necessary. Caution should be exercised as this medication may cause dizziness when driving or operating machinery. Limited effects on growth and development have been reported in children and adolescents.

Serious side effects

• Urticaria, angioedema including hypersensitivity reactions, severe allergic reactions
• Severe skin adverse reactions: Stevens-Johnson syndrome, drug reaction with eosinophilia and systemic symptoms (DRESS), lichenoid drug rash
• Respiratory issues: dyspnea, cough
• Liver issues (jaundice): jaundice, hepatitis, elevated transaminases, liver function test abnormalities, fatal and non-fatal liver failure
• Serious neurological symptoms: polyneuropathy, paralysis

Mild side effects

Headache, dizziness, constipation, nausea, abdominal pain, itching, rash, myalgia, weakness, hematuria, diarrhea, fatigue, numbness, paresthesia, chest discomfort, loss of appetite, abdominal bloating, fainting, generalized pain, muscle cramps, gout, erectile dysfunction, joint pain, memory impairment, forgetfulness, memory loss, cognitive impairment, confusion, depression, sleep disorders (including insomnia and nightmares), sexual dysfunction, gynecomastia

This medication may be sensitive to air or moisture and should be stored in a tightly sealed container. It is advisable to maintain a storage temperature between 1 to 30 degrees Celsius to preserve the medication's effectiveness.

Appearance

Pink round film-coated tablet

Package unit

30 tablets (15 tablets/PTP (AluAlu*2), 30 tablets/bottle, 100 tablets/bottle, 300 tablets/bottle