Krasygen Tablet 375 mg

Adult dose

For adults and children aged 12 years or older or weighing 40 kg or more, amoxicillin/clavulanic acid potassium is administered orally as 250 mg/125 mg, three times a day every 8 hours. In cases of severe and respiratory infections, the dose can be increased to 500 mg/125 mg at a time. For cases of renal impairment, dosages are adjusted based on creatinine clearance. For a creatinine clearance of 10 to 30 mL/min, 250 to 500 mg of amoxicillin is administered orally every 12 hours. For a creatinine clearance of less than 10 mL/min, 250 mg of amoxicillin is administered orally every 24 hours without exceeding the maximum dose. For children, the dosage is adjusted similarly. However, for dental infections, 250 mg of amoxicillin is administered three times a day for 5 days.

Child dose

For children aged 12 years or older or weighing 40 kg or more, the dosage is the same as adults. For children with renal impairment, the dosage should be adjusted similarly.

This medication is a beta-lactam antibiotic and should not be administered to patients with hypersensitivity to penicillin components. In particular, it should not be used in patients with a history of severe allergic reactions such as anaphylaxis, Stevens-Johnson syndrome, or shock. It is advisable to avoid administering this drug to patients with infectious mononucleosis or lymphocytic leukemia due to a higher risk of rash. Patients with a history of liver dysfunction or jaundice from this drug or penicillin should be cautious due to the risk of recurrence. Patients with impaired liver or kidney function may be affected in terms of drug metabolism and excretion, hence careful administration and possible dose adjustment are necessary. Caution is required for patients with a history of allergies or difficulty in oral ingestion, elderly patients, or those in poor overall condition due to the risk of bleeding from vitamin K deficiency. Patients with gastrointestinal diseases accompanied by vomiting or diarrhea should check their condition before administration as drug absorption may be impaired. Gastrointestinal side effects may include diarrhea, gastritis, and vomiting, and if severe diarrhea or abdominal pain occurs, discontinue use immediately. Signs of liver function abnormality have also been reported, and they may occur more frequently in elderly or long-term users, so liver function testing is necessary. Rarely, skin rash, itching, or severe skin reactions may occur, so if unusual symptoms occur, discontinue administration immediately and seek medical advice. Blood tests may show leukopenia or thrombocytopenia, so long-term use necessitates monitoring of blood status. Neurological symptoms such as agitation, anxiety, or seizures may occur rarely, and caution is needed in patients with impaired renal function. Renal damage or acute kidney failure symptoms have also been reported, and regular kidney function tests are recommended. Antibiotic use may lead to dysbiosis or candidiasis, so appropriate measures should be taken if symptoms arise. Symptoms of vitamin K and vitamin B group deficiencies may appear, so it is important to check nutritional status. To prevent the emergence of resistant bacteria, it is advisable to administer only for the necessary duration after sensitivity testing. Patients with a history of penicillin hypersensitivity are at risk for severe allergic reactions, so verification prior to administration is essential. Patients should be closely monitored for status after administration in case of emergencies such as anaphylactic shock. There is a risk of antibiotic-associated pseudomembranous colitis, so if severe diarrhea or abdominal pain occurs, inform medical personnel immediately. Caution is needed when used for more than 14 days as non-sensitive bacteria can proliferate. If liver dysfunction is suspected, testing should be done immediately, and administration should be stopped if necessary. Since renal excretion is the main pathway, dose adjustment is needed in patients with impaired kidney function. Avoid use in suspected infectious mononucleosis cases. If hives, skin rash, or serum sickness symptoms occur, discontinue administration immediately and follow medical guidance. Regular testing of renal function, liver function, and hematopoietic function is necessary for long-term use. Verification of a history of penicillin, cephalosporin, or other allergies is mandatory before administration. Adequate fluid intake and urine output maintenance are important during high-dose administration to prevent acute kidney damage. It is recommended for children over 12 years of age or weighing more than 40 kg. Do not administer during the first three months of pregnancy, and pregnant or breastfeeding women should use it cautiously after consulting a physician. During breastfeeding, if the infant shows symptoms such as diarrhea or skin rashes, administration should be discontinued in case of adverse effects. This drug can interact with other medications, so if taking other drugs, health professionals should be informed. Overdose may result in gastrointestinal symptoms, renal failure, seizures, and immediate medical treatment is required.

Serious side effects

• Hives
• severe swelling (angioedema)
• chest tightness
• difficulty breathing
• cold sweat
• pallor
• anaphylaxis
• Stevens-Johnson syndrome
• shock
• severe skin reactions

Mild side effects

• Diarrhea
• pseudomembranous colitis
• dyspepsia
• stomatitis
• gastritis
• glossitis
• nausea
• vomiting
• loss of appetite
• abdominal pain

This drug should be kept in a sealed container to avoid moisture, stored in a dry place below 25 degrees Celsius. Proper storage helps maintain the efficacy of the drug for an extended period.

Appearance

White or almost white oval film-coated tablet

Package unit

- - 100 tablets/PTP [10 tablets/PTP x 10]