Clotex Tablets (Clopidogrel Sulfate)

Adult dose

For patients with ischemic stroke, myocardial infarction, or peripheral artery disease, clopidogrel should be administered orally as a daily dose of 75 mg. For patients with acute coronary syndrome (unstable angina or non-Q myocardial infarction), start with a loading dose of 300 mg once daily on the first day of treatment, followed by a maintenance dose of 75 mg once daily. During this time, aspirin 75–325 mg should also be administered once daily.

This medication prevents platelets from aggregating and avoids excessive blood clotting. The efficacy of this medication may be diminished in individuals genetically predisposed to decreased function of a specific enzyme (CYP2C19), so in such cases, treatment methods should be adjusted in consultation with a doctor. Additionally, taking this medication with drugs that activate certain enzymes may increase drug concentration and elevate bleeding risk, so caution is necessary. Individuals allergic to this medication or its components, those with bleeding tendencies, those with severe liver damage, nursing mothers, and those with lactose intolerance should not take this medication. Patients who are at risk of bleeding or those who are scheduled for surgery should carefully monitor for signs of bleeding while taking this medication and may need to have blood tests if necessary. Particularly, taking this medication together with other antiplatelet or anticoagulant drugs, non-steroidal anti-inflammatory drugs (NSAIDs), and selective serotonin reuptake inhibitors (SSRIs) may increase the risk of bleeding and should be done with caution. This medication may prolong bleeding time, which means that even minor wounds may bleed for a longer duration, so if bleeding does not stop or is severe, immediate consultation with a doctor is required. While taking this medication, side effects such as headache, dizziness, dyspepsia, diarrhea, skin rashes, and others may occur, and in rare cases, blood disorders or serious bleeding may arise. If symptoms of infection (e.g., fever) develop during this medication course, prompt notification to a doctor and testing is necessary. During pregnancy, the risks to the fetus are low, but due to the possibility of bleeding during delivery, it is advisable to discontinue this medication about 5 to 7 days before the expected delivery date. Nursing mothers should consult with their doctor regarding whether to continue breastfeeding as this medication may be excreted in breast milk. Elderly patients and those with impaired kidney or liver functions may be at a higher risk of bleeding and should take this medication with caution. Excessive dosing may increase the risk of bleeding, and currently, there is no antidote for this medication; thus, severe bleeding may need treatment such as platelet transfusion. This medication should be kept out of reach of children and should not be transferred to another container for safety.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, skin peeling, pain in the oral and ocular mucosa, shortness of breath or difficulty breathing, asthma attacks, respiratory abnormality accompanied by cough and fever, yellowing of the skin or eyes (jaundice), severe lethargy, sudden and intense headache, thunderclap headache, seizures, confusion, visual disturbances, paralysis, and urination issues.

Mild side effects

• Headache
• dizziness
• abdominal pain
• dyspepsia
• diarrhea
• nausea
• rash
• pruritus
• purpura/ecchymosis
• nasal bleeding

This medication should be stored in an airtight container and kept at room temperature between 1 degree and 30 degrees Celsius. Proper storage will help maintain the medication's efficacy for an extended period.

Appearance

Pink round film-coated tablet

Package unit

30 tablets/bottle, 300 tablets/bottle