Elproxim Tablet (Cefuroxime Axetil)

Adult dose

To ensure optimal absorption, take after meals. Adults and children 12 years and older Most infections: 250mg twice daily. Severe lower respiratory tract infections, pneumonia, severe infections, or suspected infections caused by organisms with low susceptibility: 500mg twice daily. Urinary tract infections: 250mg twice daily. Uncomplicated gonorrhea: a single dose of 1g. Lyme disease: 500mg twice daily for 14 days (10~21 days). Patients with renal impairment Cefuroxime is excreted primarily by the kidneys. To compensate for delayed excretion in patients with significant renal impairment, the cefuroxime dose should be reduced as follows. Creatinine clearance ≥ 30 mL/min/1.73m2, T1/2 (hours) 1.4 - 2.4: No dosage adjustment required (standard dose: 125mg-500mg twice daily) Creatinine clearance 10 - 29 mL/min/1.73m2, T1/2 (hours) 4.6: Administer the standard single dose every 24 hours Creatinine clearance < 10 mL/min/1.73m2, T1/2 (hours) 16.8: Administer the standard single dose every 48 hours Patients undergoing hemodialysis, T1/2 (hours) 2 - 4: Administer an additional standard single dose at the end of each dialysis session

Child dose

Infants and children under 12 years, most infections: 125mg twice daily. Children 2 years and older, otitis media or severe infections: 250mg twice daily. Infants and children under 12 years, Lyme disease: 250mg twice daily for 14 days (10~21 days). There is insufficient experience with use in infants under 3 months of age. For the treatment of infections caused by Streptococcus pyogenes (Group A beta-hemolytic), this medicine should be administered for 7~10 days. This medicine should not be divided and is therefore not suitable for patients who cannot swallow tablets, such as infants and young children.

This drug is a cephalosporin antibiotic and should not be used in patients with a history of allergy to drugs in this class. Patients with a history of allergy to penicillin or other beta-lactam antibiotics, those prone to allergic reactions such as bronchial asthma, skin rashes, urticaria, patients with severe renal impairment, patients who have difficulty swallowing or in elderly patients, and patients in poor general condition should be given this drug with caution. Various adverse reactions, ranging from mild symptoms to serious side effects, may occur when using this drug, so if symptoms such as rash, urticaria, fever, difficulty breathing, or severe skin reactions occur, immediate consultation with a healthcare professional is necessary. Also, symptoms like headache, dizziness, indigestion, diarrhea, and nausea may commonly occur, so caution is needed. Long-term use of this drug can lead to excessive growth of Candida or an increase in harmful bacteria in the intestines, so if these symptoms occur, the treatment should be discontinued. If diarrhea worsens or abdominal pain persists during or after antibiotic use, it may indicate pseudomembranous colitis, and immediate notification to a healthcare professional is required. This drug can cause dizziness, so caution is needed when driving or operating machinery. Women who are pregnant or may become pregnant should carefully consider the benefits and risks of this drug if administration is necessary, and caution should also be exercised if breastfeeding. It is advisable to avoid using this drug in infants under 3 months of age as safety has not been established, and for children, syrup form is recommended due to its bitterness. In elderly patients, the risk of bleeding due to impaired renal function and vitamin K deficiency is higher, so doses and intervals should be adjusted and their condition closely monitored. This drug can worsen renal impairment when used in conjunction with other diuretics or aminoglycoside antibiotics, so caution is advised, and absorption may decrease when combined with antacids or other gastric acid suppressants, so it is preferable to take it with meals. Additionally, it may reduce the effectiveness of oral contraceptives, so caution is necessary when used together. In case of overdose, seizures may occur, so immediate medical assistance should be sought, and the drug concentration can be reduced by hemodialysis or peritoneal dialysis. Lastly, this drug should be stored out of reach of children and kept in its original container as transferring to another container poses risks of misuse or quality degradation.

• Candida overgrowth
• eosinophilia
• positive Coombs test
• thrombocytopenia
• leukopenia
• granulocytopenia
• erythrocytopenia
• hemoglobin decrease
• hematocrit decrease
• hemolytic anemia

This drug should be stored in a tightly sealed container to prevent air exposure, and it is best to store it at room temperature between 1 and 30 degrees Celsius. Proper storage will help maintain the drug's effectiveness and ensure its safe use.

Appearance

White rectangular film-coated tablets

Package unit

50 tablets (10 tablets/PTP×5)