Hyusolon Tablet (Methylprednisolone)

Adult use

The initial dose may vary from 4mg to 48mg per day as methylprednisolone, depending on the symptoms of the specific disease. In general, a low dose is sufficient for less severe conditions, although a high initial dose may be required in certain patients. The initial dose should be maintained or adjusted until a satisfactory response is obtained. If satisfactory clinical results are not obtained after a reasonable period, discontinue treatment and switch to another appropriate therapy. The dose should be individualized according to the various diseases being treated and the patient's response. After an adequate response is achieved, an appropriate maintenance dose should be determined by reducing the initial dose at suitable intervals until the lowest dose that maintains an adequate clinical response is reached. For treatment of acute exacerbations of multiple sclerosis, administering prednisolone 200mg daily for 1 week followed by prednisolone 80mg every other day for 1 month is effective (methylprednisolone 4mg is equivalent to prednisolone 5mg). Alternate-day therapy means administering twice the daily dose on one morning every 2 days. Although a single morning dose causes considerably less adrenal suppression than taking prednisolone (10mg) in 4 divided doses every 6 hours, there is evidence that when pharmacological doses are used, some suppression of adrenal activity continues into the following day. Once control is achieved, ① Switch to ADT and gradually reduce the amount of corticosteroid given every other day. ② Depending on control of disease progression, reduce the daily corticosteroid dose to the minimum effective dose as soon as possible, and then change to an alternate-day schedule. If this presents difficulties, administering 3 or even 4 times the daily dose every other day is preferable to simply doubling the daily dose. Once the patient is again under control, attempt to reduce this dose to the minimum.

This medication should not be administered to certain patients. For instance, it is contraindicated in patients allergic to this drug or its components, those with infections without effective antimicrobial agents, or those with systemic fungal infections. It should not be used in patients with herpes simplex, shingles, or chickenpox or those receiving live vaccines or attenuated live vaccines. This drug contains lactose, therefore it should not be used in patients with lactose intolerance or related genetic issues. There are also patients who should be treated with caution. For example, patients with glaucoma, tuberculosis, herpes simplex keratitis, posterior subcapsular cataracts, electrolyte imbalances, hypertension, thrombosis, and those who have recently undergone intestinal anastomosis should be careful when using this drug due to possible worsening of symptoms. Additionally, patients with a history of acute myocardial infarction, diverticulitis, peptic ulcer, psychiatric disorders, and severe osteoporosis should be treated cautiously. Patients with infections, diabetes, renal failure, hypothyroidism, fatty liver, severe myasthenia gravis, the elderly, epilepsy, and ulcerative colitis also require caution. There may be various side effects with this medication, so close observation is necessary. Fluid and electrolyte imbalances, edema, hypertension may occur, along with muscle weakness, osteoporosis, joint pain, skin changes, gastrointestinal symptoms, and psychiatric symptoms. Additionally, endocrine disorders, increased eye pressure and glaucoma, immune system disorders, and allergic reactions have been reported as side effects. Prolonged use may lead to adrenal insufficiency, and sudden discontinuation can cause serious withdrawal symptoms, so a gradual reduction is necessary. There may be a reduced resistance to infections, so special caution should be taken to avoid exposure to infectious diseases such as chickenpox and measles. This drug can interact with various medications, so if the patient is taking other medications, it is essential to consult with healthcare workers. Caution is especially needed when used in conjunction with heart-related drugs, anticoagulants, antidiabetic agents, diuretics, and antibiotics. Women who are pregnant or breastfeeding should carefully consider the benefits and risks of using this medication as it may affect the fetus or newborn, and it is recommended to discontinue breastfeeding. In children, there may be side effects such as growth delay, so it should be administered at the minimum effective dose cautiously. Elderly patients are at an increased risk for side effects such as infections, diabetes, osteoporosis, hypertension, cataracts, and glaucoma, thus careful observation is needed. If infected with chickenpox or measles while on this medication, it can lead to fatal outcomes, so medical history and vaccination status must be confirmed before administering, and immediate medical attention should be sought if infection is suspected.

Edema, sodium retention, potassium loss, fluid retention, hypokalemic alkalosis, congestive heart failure, hypertension, muscle weakness, aseptic necrosis of the femoral and humeral heads, steroid myopathy, loss of muscle mass, pathologic fractures of the pelvis, osteoporosis, vertebral compression fractures, arthralgia, tendon rupture, increased ALT, increased AST, increased ALP, nausea, dry mouth, vomiting, gastralgia, loss of appetite, increased appetite, peptic ulcer, abdominal distension, pancreatitis, esophagitis, diarrhea, delayed wound healing, facial erythema, thin and fragile skin, abnormal sweating, petechiae, purpura, suppression of skin reactions, purpura, acne, hirsutism, hair loss, pigmentation, nipple swelling, increased intracranial pressure, seizures, dizziness, headache, insomnia, euphoria, depression, Cushing's syndrome, menstrual irregularities, growth suppression in children, symptoms of latent diabetes mellitus, secondary adrenal insufficiency, pituitary non-responsiveness, decreased glucose tolerance, increased demand for insulin or oral hypoglycemic agents, suppression of adrenocorticotropic hormone secretion, increased intraocular pressure, glaucoma, posterior capsule cataract, secondary eye infections due to fungi or viruses, retinal disorders, exophthalmos, nitrogen balance, immune system disorders, allergic reactions, shock, urticaria, anaphylactic reactions, hypersensitivity reactions

This medication should be stored in an airtight container to prevent exposure to air and moisture. It is important to maintain storage temperatures between 1 degree to 30 degrees Celsius. This ensures the medication's effectiveness.

Appearance

White oval tablet

Package unit

30 tablets/bottle, 500 tablets/bottle