Unique-Pem Injection 500mg (Meropenem Hydrate)

Adult administration

As Meropenem Hydrate, administer 0.5 to 1 g (potency) daily in 2 to 3 divided doses via slow intravenous infusion over at least 30 minutes. For suspected infections in patients with pathogenic pneumonia, peritonitis, neutropenia, or sepsis, administer 1 g (potency) every 8 hours via slow intravenous infusion. For cystic fibrosis or meningitis, administer 2 g (potency) every 8 hours via slow intravenous infusion.

Child administration

For bacterial meningitis in children over 3 months of age, administer 40 mg per kg of body weight via slow intravenous infusion every 8 hours for at least 30 minutes, depending on the pathogen's susceptibility and the patient's condition, type of infection.

This medication should not be used in certain patients. For example, patients who have previously experienced a severe allergic reaction or shock to this drug, patients currently taking valproate sodium, or patients with hypersensitivity to this drug and its components should not receive it. Patients who have a history of severe allergic reactions to other carbapenem or beta-lactam antibiotics should also exercise caution. Patients with renal or liver impairment, those with central nervous system diseases, allergic individuals, elderly patients, and infants should use this medication with caution. This drug can cause various side effects, including rare occurrences of shock, skin rashes, blood abnormalities, liver and kidney dysfunction, gastrointestinal issues, central nervous system anomalies, and respiratory problems, so any unusual symptoms that arise should be reported to a healthcare professional immediately. Regular testing of liver and kidney function should be performed during treatment to detect any abnormal signs early. To prevent the development of resistant bacteria, susceptibility testing should be conducted, and this drug should only be used for the minimum necessary duration. A thorough allergy history should be taken, and the patient's condition should be closely monitored after administration; if a rash or other abnormal reactions occur, treatment should be stopped immediately and appropriate care should be provided. This drug may interact with other medications, so it is essential to inform healthcare providers of any other medications being taken. Women who are pregnant or breastfeeding should carefully consider the risks and benefits before using this drug, and it is advisable to avoid its use while breastfeeding. The safety and efficacy of this drug have not been established in infants under 3 months, so its use is not recommended. Elderly patients may experience side effects more easily due to decreased body function, requiring dose adjustment and close observation. This medication is for intravenous injection only, and should be used as soon as possible after reconstitution; it should also be used within the defined timeframe during storage for safety. Lastly, this drug may cause cross-allergic reactions with other beta-lactam antibiotics; therefore, special caution is advised for individuals with known allergies to related medications.

Serious side effects

Urticaria, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, shock, anaphylactic reaction, severe rash with fever, blistering, desquamation of skin, pain in mucous membranes of the mouth/eyes, severe skin adverse reactions, jaundice, systemic malaise, liver abnormalities, sudden and severe headache, thunderclap headache, seizures, altered consciousness, visual disturbances, paralysis, severe neurological symptoms, markedly decreased urine output, systemic

Mild side effects

• Wheezing
• dizziness
• diarrhea
• tinnitus
• sweating
• warmth
• erythema
• itching
• fever
• flushing

This drug should be stored in a sealed container that prevents air or moisture from entering, at a safe temperature between 1 to 30 degrees Celsius. Stored this way, it will maintain its effectiveness and prevent degradation.

Appearance

[For domestic use] A white to light yellow crystalline powder in a colorless transparent vial for injection [For export] A colorless transparent vial filled with a white to light yellow crystalline powder

Package unit

10 vials/box