Alzepel 5 mg (Donepezil Hydrochloride Hydrate)

Adult dose

Administer 5 mg of donepezil hydrochloride once daily before bedtime. If unusual dreams, nightmares, or insomnia occurs, consider morning dosing. After 15 days, reach a steady state; evaluate clinical response after administering 5 mg for 4-6 weeks and can increase to 10 mg with caution regarding gastrointestinal adverse effects. It can be taken by placing the orally disintegrating tablet on the tongue and swallowing with water or without water.

This medicine contains aspartame, an artificial sweetener, and should not be used by patients with hereditary diseases such as phenylketonuria. Patients who are allergic to donepezil hydrochloride, piperidine derivatives, or other components of this medication, pregnant women, women who may become pregnant, and breastfeeding women should not take this drug. Patients with heart disease, especially those with conduction disorders, should use this medication cautiously as it may cause bradycardia or arrhythmia. Patients taking non-steroidal anti-inflammatory drugs or with a history of peptic ulcers should take this medication cautiously, as increased gastric acid secretion and gastrointestinal motility may worsen symptoms. Patients with a history of asthma or chronic obstructive pulmonary disease should be cautious, as there may be increased bronchoconstriction and mucus secretion that can worsen symptoms. Patients with extrapyramidal disorders such as Parkinson's disease should be careful with this medication, as the cholinergic effects may worsen their symptoms. During the use of this medication, adverse reactions related to the heart, gastrointestinal bleeding, liver dysfunction, neurological symptoms, musculoskeletal symptoms, and others may occur; consult a healthcare provider immediately if abnormal symptoms arise. This medication is approved for the treatment of dementia, but not for other forms of dementia or memory disorders, so it should be taken under the supervision of an experienced physician after an accurate diagnosis. As this medication may affect driving or machinery operation, caution is needed at the beginning of treatment or with dosage changes. This medication can interact with various drugs; if you are taking other medications, be sure to inform your doctor or pharmacist. Pregnant or breastfeeding women are advised not to use this medication; if absolutely necessary, they should consult a professional before use. The safety for children has not been established, so it should not be used in pediatric patients. In case of overdose, serious symptoms such as nausea, vomiting, bradycardia, and respiratory depression may occur, so seek appropriate treatment immediately at a medical institution. This medication should be taken by dissolving it on the tongue, stored out of children's reach, and should be kept in its packaging as it may discolor under light.

Serious side effects

Syncope, bradycardia, heart block, myocardial infarction, heart failure, gastrointestinal bleeding, peptic ulcer, hepatitis, liver dysfunction, jaundice, seizure, cerebral hemorrhage, cerebrovascular disorders, extrapyramidal disorders (movement dysfunctions, ataxia, motor disorders, dystonia, tremors, involuntary movements, gait disorders, speech disorders), neuroleptic malignant syndrome (stiffness, extreme rigidity, dysphagia, tachycardia, blood pressure fluctuations, sweating, fever), rhabdomyolysis.

Mild side effects

Mild to moderate side effects such as headache, dizziness, insomnia, diarrhea, nausea, vomiting, loss of appetite, fatigue, muscle pain, rash, itching, increased blood pressure, weight loss, urinary incontinence, frequent urination, dehydration, fever, malaise, lethargy, drowsiness, hallucinations, agitation, aggressive behavior, anxiety, drowsiness, insomnia, tremors, confusion, delusions, insomnia, depression, and hematological abnormalities (such as anemia, leukopenia, thrombocytopenia) have been reported.

This medication should be stored in a sealed container to prevent air exposure, and it is recommended to keep it at room temperature between 1 and 30 degrees Celsius. By storing this way, the effectiveness of the medication can be maintained, and deterioration can be prevented.

Appearance

White round orally disintegrating tablet

Package unit

30 tablets (10 tablets/PTP packaging x 3)