DuoMet XR Tablet 500/5 mg

Adult dose

This drug is administered once daily with the evening meal for adults.

This drug can rarely cause a metabolic complication known as lactic acidosis, which can lead to death. Lactic acidosis is particularly dangerous in patients with impaired kidney function or conditions such as cardiopulmonary disease and sepsis, so caution is necessary. Additionally, when taken with insulin or sulfonylurea drugs, hypoglycemic symptoms may be significantly pronounced, so blood sugar should be closely monitored. This drug should not be administered to patients with certain liver diseases, muscle disorders, renal impairment, pregnant or breastfeeding women, and those with specific genetic metabolic disorders. In particular, patients with severely impaired kidney function or acute conditions such as acute heart failure, severe infections, or myocardial infarction should not use this drug. Moreover, the intake of this drug should be temporarily stopped before and after undergoing tests with iodine contrast agents, and it should be restarted only after kidney function has been confirmed to be normal. During the course of taking this drug, regular kidney and liver function tests should be conducted, and if any unusual symptoms such as muscle pain or fatigue appear, the healthcare provider should be notified immediately. Mild side effects such as gastrointestinal disturbances, headaches, dizziness, and skin rashes may occur, and in rare cases, severe skin reactions or muscle disorders may occur, so caution is required. Alcohol consumption can increase the risk of lactic acidosis, so it is advisable to avoid it while taking this drug. For elderly patients or those with reduced kidney function, dosage adjustments and regular monitoring are important, and pregnant women or those who may become pregnant should not take this medication. This drug may interact with other medications, so if other drugs are being taken, it is essential to inform the healthcare provider, especially when taken with medications affecting the liver or kidneys. In case of overdose, immediate medical treatment is required, and the components of this drug can be removed via dialysis, but there is no specific antidote. Lastly, this drug should be stored out of reach of children, kept in its original container, and caution should be exercised as dizziness may occur when driving or operating machinery.

Serious side effects

Allergic reactions including urticaria and angioedema, Stevens-Johnson syndrome, drug reaction with eosinophilia and systemic symptoms (DRESS), acute renal failure, thrombocytopenia, increased serum creatinine, jaundice, hepatitis, severe liver damage and hyperbilirubinemia, chest discomfort, dyspnea, rhabdomyolysis, severe muscle weakness, ocular muscle weakness, lactic acidosis, hypoglycemia, cough, seizures, visual disturbances, confusion of consciousness, tremors

Mild side effects

• Diarrhea
• upper abdominal pain
• constipation
• abdominal pain
• belching
• gastroesophageal reflux disease
• upper abdominal discomfort
• dyspepsia
• cellulitis
• paresthesia

This drug should be stored in a tightly closed container to prevent air or moisture from entering, and it should be kept at a safe temperature between 1 and 30 degrees Celsius. By doing so, the efficacy of the drug can be maintained for a longer period.

Appearance

Yellow oval film-coated tablet

Package unit

30 tablets (10 tablets/PTP x 3), 30 tablets/bottle