Yuyu Doxycycline Tablets (Doxycycline Hydrate)

Adult dose

○ Adults: The initial dose of doxycycline is 100 mg (potency) orally every 12 hours. The maintenance dose is 100 mg (potency) per day, divided into 1 ∼ 2 doses. ○ For severe infections, administer the initial dose every 12 hours. This drug should be administered for an additional 24 ～ 48 hours after symptoms subside and fever resolves. For streptococcal infections, continue treatment for at least 10 days to prevent the development of rheumatic fever or glomerulonephritis. Adjust the dose as appropriate according to age and symptoms.

Child dose

○ Adolescents 12 years of age and older: For those weighing 45 kg or less, the initial dose is 4 mg (potency) per kg of body weight per day, administered orally in 2 divided doses. The maintenance dose is 2 mg (potency) per kg of body weight per day, divided into 1 ∼ 2 doses. ○ Adolescents 12 years of age and older: For those weighing more than 45 kg, administer the dose corresponding to the adult dose.

This drug can cause diarrhea due to Clostridium difficile, which can lead from mild to severe colitis. Therefore, if diarrhea symptoms occur after taking antibiotics, one must consult a physician. Also, serious skin reactions may occur while taking this drug, so if there are red rashes, blisters, or mucosal damage on the skin, the medication should be stopped immediately, and healthcare professionals should be informed. This medication should not be used in patients with specific allergies, pregnant or nursing women, children under 12 years, and patients with severely impaired kidney or liver function. Patients with weak kidney function or liver impairment should be carefully monitored and have dosage adjustments while using this drug. Sensitivity to sunlight may increase while taking this medication; thus, direct sunlight or UV exposure should be avoided, and immediate action should be taken if there are any skin abnormalities. Additionally, this drug may interact with other medications, so if you’re taking other medications, be sure to inform healthcare professionals, particularly if taking oral contraceptives, anticoagulants, calcium, or iron supplements. It is safest for pregnant women or women who may become pregnant to avoid this medication, and nursing mothers should discontinue breastfeeding while using this drug. For children, the risk of teeth staining and bone growth effects means it should not be administered to children under 12 years. Elderly patients are at higher risk of adverse reactions due to decreased kidney and liver function; therefore, starting with lower doses is essential, and careful dosing should be observed. When taking, it should be taken while standing or sitting with a sufficient amount of water, particularly avoiding taking it just before bedtime to reduce the risk of esophageal irritation or ulceration. Long-term use requires regular monitoring of the liver, kidneys, hematopoietic organs, etc., and if abnormal symptoms occur, immediate consultation with healthcare professionals is necessary. In the case of overdose, symptoms may include vomiting, liver and kidney damage, esophagitis, etc., necessitating immediate visit to a medical facility for appropriate treatment.

Diarrhea, colitis, exfoliative dermatosis, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, drug reactions accompanied by eosinophilia and systemic symptoms, hemolytic anemia, neutropenia, thrombocytopenia, hypersensitivity, anaphylactic shock, angioedema, exacerbation of systemic lupus erythematosus, pericarditis, serum sickness, Henoch-Schönlein purpura, hypotension, dyspnea, tachycardia, peripheral edema, urticaria, thyroid microscopic brown discoloration, appetite loss, headache, benign intracranial hypertension, protrusion of the skull cavity, tinnitus, flushing, nausea, vomiting, dyspepsia, pancreatitis, membranous colitis, esophageal ulcer, esophagitis, enterocolitis, perianal genital inflammatory lesions, dysphagia, abdominal pain, glossitis, tooth discoloration, hepatotoxicity, hepatitis, abnormal liver function, photosensitivity reactions, rash, photo-onycholysis, arthralgia, myalgia, increased BUN, anemia, granulocyte decrease, atypical lymphocytes, lymphocyte decrease, lymphadenopathy, blood coagulation disorders, anaphylactic reactions, fever, paresthesia, anxiety, agitation, severe colitis with bloody stools, loose stools, stomatitis, sore throat, black hairy tongue, hoarseness, jaundice, onycholysis, nail color change, arthritis, kidney damage, interstitial nephritis, acute renal failure, oliguria, hematuria, vision impairment, papilledema of the optic nerve, decreased and loss of smell and taste, vitamin K deficiency, symptoms of vitamin B complex deficiency, facial, tongue, and laryngeal edema, yellow urine, decreased urinary glucose, damage to liver and renal parenchyma, esophagitis, esophageal ulcer, anaphylactic reaction

This medication should be stored in a tightly sealed container to prevent exposure to air and light; it is important to keep it in a cool, dark place at room temperature between 1 and 30 degrees.

Appearance

Green round tablets

Package unit

30 tablets/bottle, 100 tablets/bottle