Cefuroxime Tablets (Cefuroxime Axetil)

Adult dose

For optimal absorption, take after meals. Adults and children aged 12 years and older Most infections: 250mg twice daily. Severe lower respiratory tract infections, pneumonia, severe infections, or suspected infections caused by less susceptible organisms: 500mg twice daily. Urinary tract infections: 250mg twice daily. Uncomplicated gonorrhea: a single dose of 1g. Lyme disease: 500mg twice daily for 14 days (10~21 days). For the treatment of infections caused by Streptococcus pyogenes (Group A beta-hemolytic), this medicine should be administered for 7~10 days. This medicine should not be divided and is therefore not appropriate for patients who cannot swallow tablets, such as infants and young children. Patients with renal impairment Cefuroxime is eliminated primarily by the kidneys. To compensate for delayed elimination in patients with significant renal impairment, reducing the cefuroxime dose as follows is recommended. Creatinine clearance ≥ 30 mL/min/1.73m2, T1/2 (hours) 1.4 - 2.4: No dose adjustment necessary (standard dose: 125mg-500mg twice daily) Creatinine clearance 10 - 29 mL/min/1.73m2, T1/2 (hours) 4.6: Administer a standard single dose every 24 hours Creatinine clearance < 10 mL/min/1.73m2, T1/2 (hours) 16.8: Administer a standard single dose every 48 hours Patients receiving hemodialysis, T1/2 (hours) 2 - 4: Administer an additional standard single dose at the end of each dialysis session

Child dose

Infants and children under 12 years of age, most infections: 125mg twice daily. Otitis media in children aged 2 years and older, severe infections: 250mg twice daily. Infants and children under 12 years of age, Lyme disease: 250mg twice daily for 14 days (10~21 days). There is limited experience with use in infants under 3 months of age.

This drug should not be administered to patients who are allergic to cephalosporin antibiotics. Patients with a history of allergy to penicillin or other beta-lactam antibiotics, those with allergic predispositions, severely impaired kidney function, or difficulties in oral intake, especially elderly individuals, should use this medication cautiously. Use of this drug may cause hypersensitivity reactions such as skin rash, urticaria, and itching, and in rare cases may lead to severe allergic reactions or skin adverse reactions, thus symptoms should be closely monitored. Gastrointestinal symptoms such as headache, dizziness, diarrhea, nausea, and abdominal pain may commonly occur, and confusion or seizures may arise in elderly or severely infected patients, so caution is required. Regular check-ups are necessary as this drug can affect liver and kidney function, and immediate cessation and appropriate treatment should be sought in the presence of abnormal symptoms. This drug can lead to excessive growth of Candida or serious intestinal diseases such as pseudomembranous colitis, thus caution is advised during prolonged use. To prevent the emergence of resistant bacteria, it is important to conduct sensitivity tests and administer the minimum necessary duration when using this drug. As this drug may cause dizziness, care should be taken when driving or operating machinery. Women who are pregnant or breastfeeding should carefully weigh the risks and benefits before using this drug. Safety in children under 3 months has not been established, and breaking the tablet may result in a strong bitter taste, thus using a dry syrup formulation is recommended. Elderly patients may experience more adverse reactions due to decreased physiological function, and adjustments to dosage and intervals should be made, and they should be closely observed for any adverse reactions. This drug can interact with other medications, so caution is needed when used with diuretics, aminoglycoside antibiotics, probenecid, and antacids. Overdose may lead to seizures, and medical personnel should be informed immediately; dialysis or peritoneal dialysis may be used to lower the drug concentration.

• Candida overgrowth
• eosinophilia
• positive Coombs test
• thrombocytopenia
• leukopenia
• granulocytopenia
• anemia
• hemoglobin decrease
• hematocrit decrease
• hemolytic anemia

This drug should be stored in a tightly closed container to prevent exposure to air or moisture, preferably at a cool temperature below 25 degrees Celsius. Proper storage ensures the longevity of the drug’s effectiveness.

Appearance

White to off-white rectangular film-coated tablet

Package unit

100 tablets (10 tablets/PTP) x 10