Medication info

Otrivin S B nasal spray (Oxymetazoline Hydrochloride)

OTC medicationSolution
Ingredient · strength
Oxymetazoline Hydrochloride›0.5mg / 1mL
Manufacturer / importer
헤일리온코리아주식회사
Appearance
A colorless to white liquid contained in a spray bottle that dispenses a certain amount each time.
Packaging
10 mL/bottle
Approval status
Active

MFDS item code 201903221 · Notified 2019.05.20

Summary

Main use
Relief of nasal congestion, runny nose, and other symptoms of colds (acute rhinitis, sinusitis) and allergic rhinitis.
Who uses it
Adults
Adult dosage
Adolescents and adults aged 12 years and older: Spray 1-2 times into each nasal cavity per use. Do not exceed 1-2 times daily, with a minimum dosing interval of 8 hours. When using for the first time, pump several times to ensure the solution is sprayed evenly before use. Instructions for use include cleansing the nose before holding the nozzle between two fingers.

Ingredients

Importer
헤일리온코리아주식회사

Efficacy & effects

Relief of nasal congestion, runny nose, and other symptoms of colds (acute rhinitis, sinusitis) and allergic rhinitis.

  • Colds
  • acute rhinitis
  • allergic rhinitis
  • sinusitis
  • nasal congestion
  • runny nose
  • sneezing
  • heaviness in the head.
View approved original text

This medication is used to relieve symptoms such as nasal congestion, runny nose, sneezing, and heaviness in the head caused by colds, allergic rhinitis, and sinusitis.

Dosage and Administration

Adult dosage

Adolescents and adults aged 12 years and older: Spray 1-2 times into each nasal cavity per use. Do not exceed 1-2 times daily, with a minimum dosing interval of 8 hours. When using for the first time, pump several times to ensure the solution is sprayed evenly before use. Instructions for use include cleansing the nose before holding the nozzle between two fingers.

Precautions

This medication should not be used by children under 7 years of age. People who have had allergic reactions to this medication or its ingredients should not use it. Individuals taking or having discontinued, within 2 weeks, antidepressants or certain psychiatric medications must consult a specialist before using this medication. People who have had specific brain surgeries or those with angle-closure glaucoma should not use this medication. Individuals with dry nasal mucosa or atrophic rhinitis should also avoid use. Those with allergic constitutions or a history of allergic reactions to medications should consult a doctor or pharmacist before use. Patients with hypertension, heart disease, thyroid problems, diabetes, or benign prostatic hyperplasia should use this medication with caution. Patients with symptoms sensitive to adrenaline such as dizziness, insomnia, tremors, or cardiac arrhythmias should use it carefully. Rarely, severe headaches, nausea, and visual disturbances may occur; if such symptoms arise, discontinue use immediately and consult medical personnel. Do not use this medication continuously for more than 7 days, as excessive use may damage the nasal mucosa and reduce efficacy. Pregnant or breastfeeding women should consult a specialist regarding the use of this medication. If a rash, redness, swelling, or itching occurs while using this medication, stop use immediately and consult a physician. If symptoms do not improve after using for more than 3 days, inform medical personnel. Strictly adhere to the prescribed dosage and frequency, and do not use excessively for nasal congestion relief. This medication is for nasal use only and should not be used in the eyes or ears. To prevent infection, it is advisable not to share this medication. It is safe to avoid alcohol while using this medication. Supervision by a guardian is required when used by children. Be cautious as overdose may cause serious heart problems or central nervous system abnormalities. The benzalkonium chloride in this medication may cause bronchospasm or nasal mucosa irritation, so long-term use should be avoided. Store in a cool, dry place out of reach of children, avoiding direct sunlight. Do not transfer to a different container, and prevent misuse.

Side effects and when to seek care immediately

Serious side effects

  • Hives
  • severe swelling
  • elevated blood pressure
  • pulmonary edema
  • difficulty breathing
  • severe allergic reaction
  • severe headache
  • visual disturbances
  • confusion
  • shock
Show 2 more
  • apnea
  • mental disorders.

Mild side effects

  • Headache
  • insomnia
  • sedation
  • anxiety
  • irritability
  • restlessness
  • drowsiness
  • hypertension
  • irregular heart rate
  • increased heart rate
Show 13 more
  • nasal dryness
  • nasal discomfort
  • sneezing
  • dry mouth
  • stomatitis
  • dry throat
  • throat irritation
  • nausea
  • fatigue
  • rash
  • redness
  • irritation
  • itching.

Not everyone experiences these, and they can vary from person to person.

Interactions

Drug interactions

Do not use this medication with MAO inhibitors.

Food interactions

Do not consume alcohol while using this medication.

Storage

This medication may be sensitive to air or moisture, so it must be stored in a tightly sealed container. It is advisable to keep the storage temperature between 1 degree and 30 degrees Celsius to maintain efficacy and safety for a long time.

Appearance and packaging

Appearance

A colorless to white liquid contained in a spray bottle that dispenses a certain amount each time.

Package unit

10 mL/bottle

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

Questions about this medicine

  • QHow should I take care of the nozzle?

    After use, it is required to clean and dry the nozzle before closing the cap. The medication should be stored in a tightly sealed container at room temperature (1-30°C). Avoid alcohol during treatment.

    Answers 1 · 2026.09.14

  • QAfter spraying, my nose feels very dry; is that normal?

    Commonly reported symptoms include nasal dryness or discomfort, and sneezing. If such symptoms occur, or if you experience headaches, increased heart rate, etc., stop using and consult a doctor or pharmacist.

    Answers 1 · 2026.09.14

  • QWhen I first use it, the medication doesn’t come out well.

    When using for the first time, it is advised to press the pump several times to ensure that the spray is evenly distributed. If you have already sprayed in your nose and it hasn’t come out properly, do not spray it again.

    Answers 1 · 2026.09.14

See all questions
  • QHow many times can I spray it in a day?

    Individuals aged 12 and older including teenagers and adults should spray 1 to 2 times into each nostril, not exceeding 2 times a day. The minimum dosing interval is 8 hours, so even if the effect seems insufficient, do not spray more frequently.

    Answers 1 · 2026.09.14

For anything that needs medical judgment, consult a doctor or pharmacist.

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.