Mepre Tablet 4mg (Methylprednisolone)

Adult use

The initial dose may vary from 4 mg to 48 mg per day of methylprednisolone, depending on the symptoms of the specific disease. In general, low doses are sufficient for less severe conditions, but high initial doses may be required in certain patients. The initial dose should be maintained or adjusted until a satisfactory response is obtained. After an adequate response has been achieved, an appropriate maintenance dose should be determined by reducing the initial dose at appropriate intervals until the lowest dose that maintains an adequate clinical response is reached. After long-term treatment, gradual dose reduction is recommended when discontinuing the medicine. For treatment of acute exacerbations of multiple sclerosis, administration of prednisolone 200 mg daily for 1 week followed by prednisolone 80 mg every other day for 1 month is effective (4 mg of methylprednisolone is equivalent to 5 mg of prednisolone). Alternate-day therapy means administering twice the daily dose on one morning every other day. Although a single morning dose causes considerably less adrenal suppression than dividing prednisolone (10mg) into 4 doses taken every 6 hours, there is evidence that when pharmacologic doses are used, slight suppression of adrenal activity continues into the following day. The initial suppressive dose should be continued until a satisfactory clinical response is obtained, usually for 4 to 10 days for many allergic and collagen diseases. Switch to ADT and gradually reduce the amount of corticosteroid given on alternate days. As soon as possible, according to control of disease progression, reduce the daily corticosteroid dose to the minimum effective dose and then switch to an alternate-day schedule. If difficulties arise, administration of 3 times, or even 4 times, the daily dose on alternate days is preferable to simply doubling the daily dose.

This medication should not be administered to specific patients. For example, individuals who are allergic to this drug or its ingredients, those with infections where there are no effective antimicrobials, patients with herpes simplex or herpes zoster, those with chickenpox, patients receiving live vaccines, and individuals with lactose intolerance or specific genetic issues should not use it. Additionally, patients with conditions such as glaucoma, tuberculosis, cataracts, high blood pressure, thrombosis, peptic ulcers, psychosis, severe osteoporosis, diabetes, or renal failure must use this drug cautiously and may require strict observation by a physician if necessary. This medication can cause various side effects such as edema, hypertension, muscle weakness, osteoporosis, gastrointestinal disturbances, skin changes, psychiatric issues, endocrine problems, and ocular diseases, so if symptoms arise, immediate consultation with healthcare professionals is necessary. Long-term use can lead to issues like adrenal suppression, so sudden withdrawal should be avoided, and dosage should be reduced gradually. In stressful situations such as surgery or infections, the dosage may need to be temporarily increased. As this drug has immunosuppressive effects, the risk of infections may increase; therefore, it is particularly important to avoid exposure to varicella or measles and to seek immediate treatment if any infection symptoms appear. There are many interactions with other drugs when used in combination, so if there are other medications being taken, it is essential to inform the physician or pharmacist, especially when using it alongside cardiac-related drugs, antibiotics, diuretics, anticoagulants, and hypoglycemic agents. Pregnant women or those who may become pregnant should use this drug cautiously as it may affect the fetus, and it is recommended to stop breastfeeding if breastfeeding while taking this medication. For children and the elderly, the risk of side effects such as growth delays, infections, and osteoporosis may be higher, so it should be used at the minimum effective dose with close monitoring. During the use of this drug, regular check-ups with healthcare professionals and monitoring through blood tests and eye examinations are necessary, and immediate consultation should be sought if side effects occur.

Edema, sodium retention, potassium loss, fluid retention, hypokalemic alkalosis, congestive heart failure, hypertension, myasthenia, aseptic necrosis of the femoral and humeral heads, steroid myopathy, muscle atrophy, pathological fractures of the iliac bone, osteoporosis, vertebral compression fractures, arthralgia, tendon rupture, increased ALT, increased AST, increased ALP, nausea, thirst, vomiting, gastric pain, decreased appetite, increased appetite, peptic ulcer, abdominal distension, pancreatitis, esophagitis, diarrhea, delayed wound healing, facial erythema, thin and fragile skin, abnormal sweating, petechiae, ecchymosis, suppression of skin reactions, purpura, acne, hirsutism, hair loss, pigmentation, increased intracranial pressure, papilledema, convulsions, dizziness, headache, insomnia, euphoria, depression, Cushing's syndrome, menstrual irregularities, suppression of growth in children, symptoms of latent diabetes, secondary adrenal insufficiency, pituitary unresponsiveness, decreased glucose tolerance, increased demand for insulin or oral hypoglycemic agents, suppression of adrenocorticotropic hormone secretion, increased intraocular pressure, glaucoma, posterior capsule cataract, secondary eye infections, central serous chorioretinopathy, retinal disorders, exophthalmos, negative nitrogen balance, immune system disorders, allergic reactions, shock, urticaria, anaphylactic reactions, hypersensitivity reactions

This medication should be stored in a tightly closed container to prevent exposure to air or moisture. The appropriate storage temperature is between 1 degree and 30 degrees Celsius at room temperature. Storing it this way will help maintain the drug's effectiveness and safety.

Appearance

White oval tablet

Package unit

30, 300 tablets/bottle