Acytex Tablet (Acyclovir)

Adult administration

1. Treatment of herpes simplex virus infection - Acyclovir: 200 mg every 4 hours, 5 times a day for 5 days - For severely immunocompromised patients or those with gastrointestinal absorption disorders, the dose can be increased to 400 mg per dose or changed to intravenous administration. 2. Prevention of herpes simplex infections in immunocompetent patients - 200 mg every 6 hours, 4 times a day or 400 mg twice a day.

Child administration

1. Treatment of herpes simplex infections and prevention of herpes simplex infections in immunocompromised patients - Over 2 years: Administer as per adult dosage - Under 2 years: Administer 1/2 of adult dose 2. Treatment of chickenpox in children over 2 years

This medication should not be used in patients who have had allergic reactions to this medication, its components, or valacyclovir. Caution should be exercised when administering this medication to patients with impaired kidney function, as they can experience side effects related to the central nervous system. Patients with impaired liver function should also use this medication cautiously, as there is a risk of exacerbating liver function. In infants and children, this medication should only be used minimally when necessary, and elderly patients need to be monitored closely when using this medication. During the use of this medication, severe allergic reactions such as shock or anaphylaxis may rarely occur, so if symptoms like low blood pressure, breathing difficulties, or chest tightness appear, medication use should be immediately stopped and medical assistance should be sought. Skin reactions such as rashes, fever, blisters, or hives may occur, and if these symptoms appear, medication should be discontinued, and appropriate measures should be taken. Hair loss, severe dermatitis, or serious damage to skin and mucous membranes may rarely occur. This medication can affect mental status, causing various neurological symptoms such as altered consciousness, confusion, hallucinations, seizures, drowsiness, anxiety, etc., particularly in elderly patients or those with impaired kidney function. It may affect kidney function, potentially leading to symptoms like renal failure, hematuria, or proteinuria, so caution is required. Blood cell abnormalities can occur, resulting in conditions like anemia, leukopenia, or bleeding. Liver-related side effects including liver dysfunction, hepatitis, or jaundice have also been reported. Gastrointestinal symptoms such as gastritis, nausea, vomiting, diarrhea, and abdominal pain may occur; if these symptoms appear, medication should be discontinued, and medical consultation sought. Systemically, fever, muscle weakness, headache, and swelling may appear. Musculoskeletal symptoms such as myalgia or arthralgia have also been reported. Cardiovascular symptoms can include irregular heartbeat, blood pressure changes, and chest pain. Urinary issues such as dysuria or urinary obstruction may rarely occur. If there is no improvement in symptoms within a certain period after starting treatment with this medication, alternative treatment methods should be considered, especially if administered in the early stage of the condition for best results. Patients with weakened immune systems may require treatment in the form of intravenous injection. Adequate fluid intake during the course of administration is essential to reduce the risk of dehydration and nephrotoxicity. When treating recurrent genital herpes, continued administration after long-term use should be discussed with a physician. Caution should be taken during medication use as impaired consciousness may occur, affecting driving or machine operation, particularly for patients with decreased kidney function. Drug interactions may occur, especially with medications that affect kidney function, probenecid, cimetidine, theophylline, or mycophenolate mofetil, necessitating close attention. Women who are pregnant or of childbearing potential should only use this medication if the benefits outweigh the risks, and breastfeeding should be discontinued as the drug can be transferred to breast milk. Safety in infants and children is not established, thus it should be used cautiously only when necessary. Elderly patients should adjust dosage and administration intervals due to prolonged retention of the medication in the body caused by decreased kidney function, ensuring adequate fluid intake. In case of overdose, kidney damage can occur, so patients should be closely monitored and may require treatment such as dialysis if necessary. This medication may cause genetic anomalies or affect reproductive functions at high doses, but such effects have not been reported within recommended doses.

Serious side effects

Hives, severe swelling, chest tightness, difficulty breathing, cold sweat, pallor, shock, anaphylactic shock, anaphylactoid reactions, mucocutaneous syndrome (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), skin peeling, pain in oral/ocular mucosa, severe allergic reactions, severe skin reactions, respiratory distress, asthma attacks, cough with fever respiratory anomalies, liver abnormalities (jaundice), skin or ocular symptoms

Mild side effects

• Photosensitivity
• fixed drug eruption
• rash
• fever
• blisters
• alopecia
• erythema multiforme
• altered consciousness
• spatial disorientation
• attention deficit

This medication must be stored in a tightly sealed container to avoid exposure to air or moisture. It is important to maintain a storage temperature between 1°C and 30°C at room temperature.

Appearance

Light blue round tablet

Package unit

For domestic use: 30 tablets/bottle, 200 tablets/bottle, for export: 100 tablets (10 tablets/PTPX10)