Bivozon Loxifene Hydrochloride Tablet

Adult dose

Take 60 mg orally once daily as Loxifene Hydrochloride.

This medication may increase the risk of blood clots in the blood. If you are immobile for an extended period, you should discontinue this medication and may resume it once your condition improves. This drug is primarily metabolized in the liver, so it is not advisable for patients with poor liver function. Regular liver function tests should be conducted if liver dysfunction is suspected. The use of this drug is not recommended for premenopausal women. It should be used with caution in postmenopausal women with cardiovascular disease or at high risk, as the risk of stroke may also increase. This medication should not be used for the prevention of cardiovascular disease. Additionally, the concurrent use of systemic estrogen is not recommended. Women who are pregnant or may become pregnant, or breastfeeding, should not take this medication. Patients with a history of thrombosis, liver dysfunction, unexplained uterine bleeding, or suspected endometrial cancer should also avoid this drug. Patients who are immobile for a prolonged period or those with antiphospholipid syndrome should not be administered this medication. Patients with certain genetic metabolic disorders such as lactose intolerance should also refrain from taking this drug. Patients with a history of elevated triglycerides in the blood or poor kidney function should use this medication with caution and carefully monitor their condition. During treatment with this medication, symptoms such as leg cramps, facial flushing, cold symptoms, and peripheral edema may occur, especially during the first six months of treatment. Because of the risk of thrombosis, any unusual symptoms should be discussed immediately with healthcare professionals. While this medication does not cause endometrial hyperplasia, if uterine bleeding occurs while taking it, a specialist evaluation is necessary. The safety for patients with breast cancer has not been sufficiently established; thus, it is advisable to take this medication after completing therapy for breast cancer. This drug is for use only in postmenopausal women and should not be given to men or children. It is recommended to supplement calcium and vitamin D if intake is insufficient, and improving smoking and drinking habits is advised. While most drug concentrations remain largely unaffected when used in conjunction with other medications, caution is needed with certain drugs. In the event of an overdose, leg cramps or dizziness may occur, so it is essential to adhere to the prescribed dosage. Children, pregnant women, and nursing mothers should not take this drug, and it should be kept out of reach of children for their safety.

Serious side effects

Deep vein thrombosis, pulmonary embolism, retinal vein thrombosis, superficial venous thrombophlebitis, stroke, death related to deep venous thrombosis and pulmonary embolism, thrombocytopenia, arterial thrombosis, retinal vein occlusion, hypertension, including migraine headaches

Mild side effects

• Vasodilation (flushing)
• leg cramps
• cold symptoms
• peripheral edema
• slight decrease in platelet count
• moderate elevation in AST and/or ALT
• gallstones
• vaginal bleeding
• itching
• palpitations

This medication should be stored in a tightly sealed container to prevent exposure to air or moisture. It is advisable to maintain a storage temperature between 15 to 30 degrees Celsius (59 to 86 degrees Fahrenheit).

Appearance

White oval film-coated tablet

Package unit

28 tablets (14 tablets PTP x 2)