Donegreen Tablets 10 mg (Donepezil Hydrochloride Monohydrate)

Adult dose

For Donepezil Hydrochloride, administer 5 mg once daily before bedtime. For 4 to 6 weeks, maintain the dosage at 5 mg and evaluate clinical response during this period. If necessary, the dosage may be increased to 10 mg; however, be cautious regarding gastrointestinal adverse reactions at the 10 mg dose. Women over 85 years old and underweight should not exceed 5 mg daily, with careful monitoring required.

Child dose

No experience of use in pediatric patients.

This medicine contains Donepezil Hydrochloride Monohydrate as its active ingredient and is used for the treatment of symptoms associated with Alzheimer's disease. Firstly, this medication should not be administered to certain patients. For instance, individuals allergic to this medicine or its components, pregnant women, or women who may become pregnant, and nursing mothers should not take this medicine. Moreover, patients with lactose intolerance or specific genetic metabolic disorders should also avoid this medicine. Patients with heart disease or cardiac conduction abnormalities should use this medication cautiously as it may slow heart rate or cause arrhythmias. Additionally, patients with peptic ulcers or currently using non-steroidal anti-inflammatory drugs should be cautious as gastrointestinal symptoms may worsen. Patients with a history of asthma or obstructive pulmonary disease should also proceed with caution when taking this medication, as symptoms may worsen. Care should be taken for those with extrapyramidal disorders, such as Parkinson's disease, as symptoms may deteriorate with this drug. This medication contains the pigment Yellow No. 5, requiring caution from patients allergic to this component. Reported side effects while taking this medication include dizziness, nausea, vomiting, diarrhea, fatigue, headache, loss of appetite, insomnia, hallucinations, bradycardia, heart block, liver dysfunction, cerebrovascular abnormalities, and muscular issues. In severe cases, there is a risk of fainting, cardiac arrest, acute pancreatitis, and acute renal failure, and any emerging symptoms should prompt immediate consultation with healthcare professionals. This medication is approved for use only in patients with Alzheimer's disease and should not be used for other forms of dementia or memory disorders. Treatment should be conducted under the supervision of an experienced physician, with periodic evaluations of the patient's condition determining whether to continue therapy. Caution is necessary while driving or operating machinery as this medication may impair these abilities, particularly during initial use or after dose adjustments. This medication can interact with several drugs; therefore, it is essential to inform healthcare professionals if taken concomitantly with cardiac medications, antibiotics, antidepressants, antipsychotics, or anti-inflammatory pain relievers. Pregnant or nursing women are generally advised against using this medication, and if unavoidable, careful decisions must be made in consultation with specialists. The safety of this medication in children has not been established, and it is not to be used in pediatric patients. In the case of overdose, symptoms may include nausea, vomiting, bradycardia, respiratory depression, and convulsions, requiring immediate medical attention. Atropine may be used as an antidote in cases of overdose. Lastly, this medication should be kept out of reach of children, and changing the storage container is not advisable for maintaining quality.

Serious side effects

• Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe allergic reactions
• Severe rash, blistering, skin peeling accompanied by high fever, pain in oral/ocular mucosa, severe skin adverse reactions
• Breathing problems, asthma attacks, breathing problems accompanied by cough and fever
• Yellowing of the skin or eyes (jaundice), profound lethargy, liver dysfunction (jaundice)
• Sudden and severe headaches, seizures, altered consciousness

Mild side effects

• Nausea
• vomiting
• diarrhea
• loss of appetite
• dizziness
• headache
• fatigue
• insomnia
• drowsiness
• myalgia

This medicine should be stored in a tightly closed container that is not exposed to air, and it is best kept at room temperature between 1 to 30 degrees Celsius. This storage method helps maintain the effectiveness of the medicine and prevents degradation.

Appearance

Yellow round film-coated tablet

Package unit

30 tablets/bottle