Pavisfebuxostat Tablets 80 Milligrams

Adult dosage

1. Adults This medicine is administered at 40mg or 80mg once daily, regardless of meals. This medicine acts very rapidly; therefore, recheck the serum uric acid level after 2 weeks. The treatment goal is to lower and maintain the serum uric acid level below 6 mg/dL(357 μmol/L). 2. Patients with renal impairment No dose adjustment is necessary in patients with mild or moderate renal impairment. The safety and efficacy of this medicine have not been adequately evaluated in patients with severe renal impairment (creatinine clearance below 30mL/min). 3. Patients with hepatic impairment No special dose adjustment is necessary in patients with mild or moderate hepatic impairment. Only limited information is available for patients with moderate hepatic impairment, and the efficacy and safety of this medicine have not been studied in patients with severe hepatic impairment (Child Pugh class C).

This medication may increase cardiovascular mortality in gout patients with cardiovascular disease. Therefore, it is advisable for patients with a history of cardiovascular diseases such as myocardial infarction, stroke, or unstable angina to consider alternative therapies. Patients with allergies to the active ingredient or excipients, those currently taking mercaptopurine or azathioprine, and patients with lactose intolerance or certain genetic metabolic disorders should not use this medication. Patients with a history of liver disease should have regular liver function tests during treatment, and thyroid hormone levels should also be closely monitored due to possible changes in thyroid function. Patients with ischemic heart disease or congestive heart failure should use this medication cautiously, and those taking theophylline should do so with caution when used in combination. Do not initiate treatment during an acute gout attack, and preventive treatment with non-steroidal anti-inflammatory drugs or colchicine is recommended during the initial administration as gout attacks may temporarily worsen. While taking this medication, side effects such as liver function abnormalities, diarrhea, headaches, rashes, dizziness, and fatigue may occur; consult healthcare professionals if symptoms arise. If any cardiovascular symptoms or signs appear, inform healthcare professionals immediately and seek appropriate care. It is unsafe for pregnant or breastfeeding women to take this medication, and it has not been tested in children or adolescents under 18 years old. No special dosage adjustments are necessary for the elderly, but caution is warranted due to possible variations in sensitivity among individuals. This medication may interact with certain drugs, so inform healthcare professionals about any other medications being taken, especially mercaptopurine, azathioprine, and theophylline, which should be avoided in combination. There is no specific antidote for overdose; symptomatic treatment will be administered based on symptoms. Store this medication out of reach of children, and no special storage conditions are required.

Liver dysfunction, dizziness, diarrhea, headache, rash, nausea, fatigue, joint pain, limb pain, gout, myalgia, pruritus, dyspnea, anemia, idiopathic thrombocytopenic purpura, leukocytosis, leukopenia, neutropenia, pancytopenia, splenomegaly, thrombocytopenia, angina, atrial fibrillation, atrial flutter, heart murmur, electrocardiogram abnormalities, palpitations, bradycardia, tachycardia, hearing loss, tinnitus, vertigo, blurred vision, abdominal distension, abdominal pain, constipation, dry mouth, dyspepsia, flatulence, increased bowel frequency, gastritis, gastroesophageal reflux disease, gastrointestinal discomfort, gum pain, hematemesis, excessive hydrochloric acid, passage of blood in stool, oral ulcer, pancreatitis, gastric ulcer, vomiting, asthenia, chest pain, chest discomfort, edema, emotional disturbances, gait disturbances, influenza-like symptoms, mass, pain, thirst, cholecystitis, diabetes mellitus, hepatic steatosis, hepatitis, hepatomegaly, hypersensitivity, herpes zoster, loss of appetite, decreased appetite, increased appetite, dehydration, diabetes, hypercholesterolemia, hyperlipidemia, hypertriglyceridemia, hypokalemia, weight loss, weight gain, arthritis, joint stiffness, joint swelling, muscle cramping, muscle fasciculation, muscle stiffness, muscle weakness, musculoskeletal pain, muscle rigidity, taste changes, balance disturbances, cerebrovascular accident, Guillain-Barré syndrome, headache, incomplete paralysis, sensory loss, olfactory impairment, heat stroke, drowsiness, mental disorders, migraine, sensory abnormalities, somnolence, transient ischemic attack, tremor, agitation, anxiety, depression, insomnia, excitability, decreased libido, nervousness, panic attacks, personality changes, hematuria, nephrolithiasis, frequency of urination, proteinuria, renal failure, renal insufficiency, urinary urgency, urinary incontinence, mastalgia, erectile dysfunction, gynecomastia, bronchitis, cough, dyspnea, epistaxis, nasal dryness, sinus hypersecretion, pharyngeal edema, airway congestion, sneezing, throat irritation, upper respiratory tract infection, alopecia, angioedema, dermatitis, papular urticaria, petechiae, eczema, hair discoloration, abnormal hair growth, hyperhidrosis, skin peeling, petechial hemorrhage, photosensitivity, pruritus, purpura, skin discoloration, changes in pigmentation, skin lesions, axillary hyperhidrosis, urticaria, flushing, facial flushing, hypertension, hypotension, prolonged activated partial thromboplastin time, increased creatinine, decreased bicarbonate, increased sodium, abnormal EEG, increased glucose, increased cholesterol, increased triglycerides, increased amylase, increased potassium, increased thyroid-stimulating hormone, decreased platelet count, decreased hematocrit, decreased hemoglobin, increased MCV, decreased erythrocytes, increased creatinine, increased blood urea, increased blood urea/creatinine ratio, increased CPK, increased ALP, increased LDH, increased PSA, increased urine output, decreased urine output, decreased lymphocyte count, decreased neutrophil count, increased white blood cell count, decreased white blood cell count, abnormal blood coagulation tests, increased low-density lipoprotein, prolonged prothrombin time, urinary casts, positive urinary white blood cells, positive urinary protein, contusion, Stevens-Johnson syndrome, toxic epidermal necrolysis, acute anaphylactic reaction, shock, liver failure, jaundice, liver dysfunction, agranulocytosis, rhabdomyolysis

Store this medication in a tightly closed container to protect it from air and moisture. Also, the medication should be kept at room temperature, ideally between 1 and 30 degrees Celsius, avoiding extremes of heat or cold.

Appearance

Pale yellow to yellow oblong film-coated tablet with a score line on one side

Package unit

28 tablets/bottle