Medication info
Putidine Tablets 10mg (Lafutidine)

Putidine Tablets 10mg (Lafutidine)

Prescription medicationTablet
Ingredient · strength
Lafutidine›10mg / 1 tablet
Manufacturer / importer
Anguk Pharmaceutical Co., Ltd.
Appearance
White round film-coated tablet
Packaging
30 tablets/bottle, 300 tablets/bottle
Approval status
Active

MFDS item code 201902683 · Approved 2019.04.26 · Insurance code 650205170

Summary

Main use
Treatment of gastrointestinal disorders (such as ulcers and gastritis); pre-anesthetic medication; combination therapy with antibiotics for Helicobacter pylori
Who uses it
Adults
Adult dosage
1. Short-term treatment of gastric ulcers: The usual dose is 10mg of lafutidine per dose, orally twice daily in the morning and at bedtime. In clinical trials of up to 8 weeks, most ulcers healed within 8 weeks, although healing time may vary in some patients. 2. Short-term treatment of duodenal ulcers: The usual dose is 10mg of lafutidine per dose, orally twice daily in the morning and at bedtime. In clinical trials of up to 6 weeks, most ulcers healed within 6 weeks, although healing time may vary in some patients. 3. Improvement of gastric mucosal lesions in acute and chronic gastritis: The usual dose is 10mg of lafutidine orally once daily at bedtime. In clinical trials of up to 2 weeks, most lesions healed within 2 weeks, although healing time may vary in some patients. 4. Combination therapy with antibiotics for patients with peptic ulcers infected with Helicobacter pylori: Administer lafutidine 20mg, clarithromycin 500mg, and amoxicillin 1000mg twice daily for 7 or 14 days. 5. Premedication for anesthesia: The usual dose is 10mg of lafutidine per dose, administered orally twice (at bedtime on the day before surgery and 2 hours before anesthesia on the day of surgery). 6. Treatment of reflux esophagitis: Administer 10mg of lafutidine per dose orally twice daily.

Ingredients

Manufacturer
Anguk Pharmaceutical Co., Ltd.

Efficacy & effects

Treatment of gastrointestinal disorders (such as ulcers and gastritis); pre-anesthetic medication; combination therapy with antibiotics for Helicobacter pylori

  • Gastric ulcer
  • duodenal ulcer
  • gastric mucosal lesions due to acute gastritis
  • chronic gastritis
  • peptic ulcer
  • gastroesophageal reflux disease
View approved original text

This medication treats gastric ulcers and duodenal ulcers and improves gastric mucosal damage caused by acute and chronic gastritis. For patients with peptic ulcers due to Helicobacter pylori infection, it increases treatment efficacy when used in combination with antibiotics. Additionally, it is administered before surgery to suppress gastric acid secretion and is also used to treat gastroesophageal reflux disease. It is effectively used for various gastrointestinal disorders.

Dosage and Administration

Adult dosage

1. Short-term treatment of gastric ulcers: The usual dose is 10mg of lafutidine per dose, orally twice daily in the morning and at bedtime. In clinical trials of up to 8 weeks, most ulcers healed within 8 weeks, although healing time may vary in some patients. 2. Short-term treatment of duodenal ulcers: The usual dose is 10mg of lafutidine per dose, orally twice daily in the morning and at bedtime. In clinical trials of up to 6 weeks, most ulcers healed within 6 weeks, although healing time may vary in some patients. 3. Improvement of gastric mucosal lesions in acute and chronic gastritis: The usual dose is 10mg of lafutidine orally once daily at bedtime. In clinical trials of up to 2 weeks, most lesions healed within 2 weeks, although healing time may vary in some patients. 4. Combination therapy with antibiotics for patients with peptic ulcers infected with Helicobacter pylori: Administer lafutidine 20mg, clarithromycin 500mg, and amoxicillin 1000mg twice daily for 7 or 14 days. 5. Premedication for anesthesia: The usual dose is 10mg of lafutidine per dose, administered orally twice (at bedtime on the day before surgery and 2 hours before anesthesia on the day of surgery). 6. Treatment of reflux esophagitis: Administer 10mg of lafutidine per dose orally twice daily.

Precautions

This medicine should not be used by patients who are allergic to certain components. This medication contains lactose; therefore, patients with genetic conditions that prevent lactose breakdown should avoid it. Patients who are allergic to soybean oil, soy, or peanuts should also refrain from using this drug. Patients with a history of drug allergy should use this medication with caution, and those with impaired liver or kidney function need to be cautious as well. Patients undergoing dialysis, elderly individuals, or those with hyperlipidemia or lipid metabolism disorders should also take this drug carefully. Since this medicine can cause severe allergic reactions, if symptoms such as facial pallor, decreased blood pressure, or difficulty breathing appear, stop taking it immediately and go to the hospital. Liver function may worsen, and symptoms of jaundice may appear, so liver condition should be monitored regularly. There may be side effects such as decreased blood cell counts; if symptoms such as pharyngitis, general fatigue, or fever occur, you must inform a hospital. Rarely, serious side effects like skin rashes, seizures, or heart problems may appear, so if any abnormal symptoms occur, consult healthcare professionals immediately. Gastrointestinal symptoms may include constipation, diarrhea, nausea, vomiting, and abdominal distension. Central nervous system symptoms have been reported to include headaches, insomnia, drowsiness, hallucinations, and consciousness disorders. In the cardiovascular system, symptoms such as chills, heat sensation, and facial flushing may appear. Changes in leukocyte or platelet counts may occur in blood tests, so regular testing is necessary. Liver function test results may elevate, and renal dysfunction may also be observed. While taking this medication, symptoms of malignancy may be masked, so if there are symptoms such as weight loss, repetitive vomiting, or vomiting blood, tests must be done. If gastric cancer is suspected, accurate diagnosis should be made through endoscopy and consumption of this drug should be discontinued if confirmed malignant. Treatment progress should be monitored carefully, and it should not be used for longer than necessary. Blood, liver, and kidney functions should be checked periodically. Patients at risk of lipid overload should monitor their blood lipid levels and adjust the dosage if necessary. The elderly may have decreased physical function, so dosage and administration intervals should be adjusted, and their condition should be observed closely. Dialysis patients should start cautiously from a low dose as drug concentration may increase. Pregnant women should use it only when deemed necessary by a doctor, and nursing mothers are advised against using it since this drug can be excreted in breast milk. Safety in children has not been established, and use is not recommended. This medication should be stored out of reach of children and kept in its original container to maintain its quality.

Side effects

  • Shock
  • anaphylactic symptoms
  • facial pallor
  • hypotension
  • generalized urticaria
  • dyspnea
  • liver function impairment
  • jaundice
  • agranulocytosis
  • pharyngodynia
Show 82 more
  • generalized malaise
  • fever
  • thrombocytopenia
  • pancytopenia
  • aplastic anemia
  • seizures
  • interstitial nephritis
  • Stevens-Johnson syndrome
  • Reiter's syndrome
  • rhabdomyolysis
  • AV block
  • ventricular contraction failure
  • constipation
  • diarrhea
  • hard stools
  • nausea
  • vomiting
  • abdominal distension
  • anorexia
  • headache
  • insomnia
  • drowsiness
  • reversible confusional state
  • hallucinations
  • altered consciousness
  • dizziness
  • chills
  • warmth sensation
  • facial flushing
  • leukocytosis
  • eosinophilia
  • leukopenia
  • erythrocytopenia
  • decreased hematocrit
  • elevated ALT
  • elevated AST
  • elevated Al-P
  • elevated γ-GTP
  • elevated T-Bil
  • elevated LDH
  • elevated TTT
  • abnormal urinary protein
  • elevated BUN
  • elevated serum uric acid
  • elevated Cl
  • prolonged survival
  • elevated Na
  • decreased K
  • gynecomastia
  • edema
  • malaise
  • glossitis
  • headache
  • chest pain
  • subdural hematoma
  • urticaria
  • skin rash
  • abdominal pain
  • dyspepsia
  • enteritis
  • gastric ulcer
  • erosive gastritis
  • duodenitis
  • distension
  • nasopharyngitis
  • upper respiratory infection
  • bronchopneumonia
  • tinea
  • cough
  • pharyngeal pain
  • pharyngeal discomfort
  • wet cough
  • fatigue
  • chest pain
  • limb pain
  • joint pain
  • cervical pain
  • pruritus
  • acne
  • contusion
  • insomnia
  • non-alcoholic fatty liver disease

Not everyone experiences these, and they can vary from person to person.

Storage

This medication must be stored in a tightly sealed container to prevent exposure to air or moisture. The storage temperature should be maintained between 1 to 30 degrees Celsius at room temperature. This will help ensure the safety of the drug's effectiveness.

Appearance and packaging

Appearance

White round film-coated tablet

Package unit

30 tablets/bottle, 300 tablets/bottle

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.