Yuhan Meropenem Injection 1 gram (Meropenem Hydrate)

Adult administration

As Meropenem hydrate, administer 0.5 to 1 g (potency) daily, divided into 2 to 3 doses via intravenous drip for over 30 minutes. For suspected infections in patients with pathogenic pneumonia, peritonitis, or neutropenia, administer 1 g (potency) intravenously every 8 hours. For cystic fibrosis and meningitis, administer 2 g (potency) intravenously every 8 hours.

Child administration

For bacterial meningitis in children over 3 months, administer 40 mg per kg of body weight via intravenous drip every 8 hours over 30 minutes. Adjust dosage appropriately depending on symptoms, with a maximum of 2 g (potency) per day for severe, refractory infections.

This medication should not be used in patients who have previously experienced shock reactions due to this medication. Additionally, it should not be used in patients taking sodium valproate as it can lower the blood concentration of valproate and increase the risk of seizure recurrence. Patients with allergies to this medication or its components, or those who have had severe allergic reactions to other carbapenem or beta-lactam antibiotics should not be treated. Caution is advised in patients with allergic predispositions or with frequent allergic symptoms such as bronchial asthma and rashes, as well as in patients with renal or hepatic dysfunction, with a need for dosage adjustment or careful monitoring. Especially, patients with neurological diseases, the elderly, infants, and those in poor general health should be used with caution. This medication can rarely cause severe allergic reactions such as shock or anaphylaxis, so the patient's condition must be monitored closely during administration. If hypersensitivity reactions such as rashes, hives, or itching occur, administration should be stopped immediately and treatment should be initiated. Blood tests may show leukopenia, anemia, and platelet abnormalities, so regular blood status checks are necessary. Liver function impairment may occur, so liver function tests should be conducted during long-term use. There is also a risk of worsening renal function, so regular kidney function tests should be performed. Severe diarrhea or pseudomembranous colitis can occur in the gastrointestinal tract, so if abdominal pain or diarrhea symptoms present, consult a physician immediately. Central nervous system symptoms such as seizures or consciousness disturbances may appear, so patients with neurological disorders should take special care. It may also affect the respiratory system; thus, if asthma or pneumonia symptoms occur, administration should be stopped immediately. Serious skin reactions such as Stevens-Johnson syndrome or toxic epidermal necrolysis may manifest, so the condition of the skin should be closely monitored. This medication can induce a tendency for bleeding due to vitamin K deficiency, so caution is advised for patients with bleeding symptoms. This medication may interact with other drugs, so it is essential to inform the physician, especially if taking valproate, antiepileptic drugs, contraceptives, or warfarin. Pregnant women or those who may become pregnant should only use this medication if the therapeutic benefits outweigh the risks. Nursing mothers should avoid breastfeeding as this drug may be excreted in breast milk. Use in infants under three months is avoided as safety and efficacy have not been established. The elderly should have dosages and intervals adjusted carefully due to reduced bodily functions and a higher risk of side effects. This medication is for intravenous use only and should be administered as soon as possible after reconstitution. Headaches, dizziness, and confusion may occur during administration, so caution is needed when driving or operating machinery. If symptoms of myalgia or dark urine appear, administration should be stopped immediately and treatment initiated. Prior to administration, allergies to past beta-lactam drugs must be confirmed.

Serious side effects

Shock, anaphylactic reactions, hives, severe swelling, chest tightness, difficulty breathing, cold sweat, pallor, severe allergic reactions, high fever with severe rash, blistering, skin sloughing, pain in mouth/eyes mucosa, severe skin adverse reactions, difficulty breathing or shortness of breath, asthma attacks, respiratory distress accompanied by cough and fever, jaundice, markedly lethargic, liver

Mild side effects

• Oral abnormalities
• wheezing
• dizziness
• changes in stool
• tinnitus
• sweating
• rash
• warmth
• erythema
• itching

This medication should be stored in a sealed container to prevent contact with air, ideally at a temperature between 1 and 30 degrees Celsius. Proper storage helps maintain the drug's effectiveness and prevents degradation.

Appearance

A colorless transparent vial filled with crystalline powder ranging from white to light yellow.

Package unit

10 vials