Citrex Capsule 100 mg (Celecoxib)

Adult dosage

The minimum recommended dose of this medicine should be adjusted for each patient and may be administered regardless of meals. ○ Adults: 1. Osteoarthritis (degenerative arthritis): Take 200 mg of celecoxib once daily, or 100 mg per dose twice daily. 2. Rheumatoid arthritis: Take 100 mg or 200 mg of celecoxib per dose twice daily. 3. Ankylosing spondylitis (AS): Administer 200 mg of celecoxib once daily, or 100 mg per dose twice daily. If no effect is observed after 6 weeks, a dose of up to 400 mg per day may be administered. If no effect is observed after 6 weeks of treatment with 400 mg per day, another treatment method should be considered. 4. Acute pain and primary dysmenorrhea: The initial recommended dose is 400 mg of celecoxib, with an additional 200 mg on the first day of administration if needed. From the second day of administration, the recommended dose, if needed, is 200 mg per dose twice daily. ○ Patients with hepatic impairment: For patients with moderate hepatic impairment (Child-Pugh Class II), the dose should be reduced to approximately 50% of the recommended daily dose.

This medication can cause gastrointestinal bleeding in individuals who regularly consume more than three alcoholic drinks a day; therefore, consultation with a doctor or pharmacist is essential. This medication may increase the risk of serious thrombotic reactions such as cardiovascular diseases, myocardial infarction, and stroke, so it should be used at the lowest possible dose for the shortest duration, and patients should immediately inform healthcare providers if cardiovascular symptoms occur. Due to the risk of gastrointestinal perforation, ulcers, or bleeding, elderly patients or those with a history of gastrointestinal diseases must be closely monitored, and if symptoms such as abdominal pain, black stools, or hematemesis occur, immediate treatment should be sought. This medication should not be administered to individuals with specific allergies, severe liver or kidney impairment, pregnant or breastfeeding women, or patients with heart diseases, and safety and efficacy have not been established for patients under 18 years of age. Patients with decreased liver or kidney function, asthma, or hypertension should use this medication cautiously, and liver function, kidney function, and blood pressure should be regularly monitored during use. This medication can interact with various drugs, so if other medications are taken, it’s crucial to inform healthcare providers, especially if taken with antihypertensives, anticoagulants, immunosuppressants, or antidepressants. Women who are pregnant or planning to become pregnant should avoid taking this medication, and if taken during pregnancy, it should be discontinued due to potential side effects on the fetus. Dizziness or drowsiness may occur while taking this medication, thus caution is advised when driving or operating machinery, and regular blood tests and liver and kidney function tests should be performed during long-term use to check for abnormalities. If symptoms of hypersensitivity such as skin rashes, itching, or difficulty breathing occur after taking this medication, it should be discontinued immediately, and healthcare providers should be consulted. In case of overdose, symptoms such as vomiting, drowsiness, and gastrointestinal bleeding may occur, and immediate medical attention should be sought for appropriate treatment. This medication should be kept out of reach of children, and transferring it to another container could pose a risk of accidents and quality degradation, so care should be taken.

Gastrointestinal bleeding, cardiovascular thrombotic reactions, myocardial infarction, stroke, perforation of the upper and lower gastrointestinal tract, ulcers, bleeding, bronchitis, sinusitis, upper respiratory infections, urinary tract infections, pharyngitis, rhinitis, anemia, thrombocytopenia, hypersensitivity, insomnia, anxiety, altered mental state, dizziness, muscle tension, drowsiness, blurred vision, tinnitus, palpitations, congestive heart failure, arrhythmia, tachycardia, hypertension, flushing, cough, vomiting, abdominal pain, diarrhea, dyspepsia, bloating, gastric ulcer, dental diseases, duodenal ulcer, esophageal ulcer, intestinal perforation, pancreatitis, elevated liver enzymes, pruritus, rash, urticaria, petechiae, angioedema, alopecia, vesicular dermatitis, peripheral edema, facial edema, influenza-like illness, injury, headache, leg cramps, tension, sensory decrease, migraine, neuralgia, neuropathy, sensory disturbances, cerebral infarction, aseptic meningitis, ataxia, suicide, loss of smell, loss of taste, back pain, allergy exacerbation, allergic reaction, weakness, chest pain, fluid retention, generalized edema, facial swelling, fatigue, lethargy, fever, flushing of the face, influenza syndrome, pain, peripheral pain, sepsis, sudden death, anaphylactic-like reaction, angioedema, loss of appetite, increased appetite, depression, nervous hyperreactivity, drowsiness, fatal intracranial hemorrhage, hallucinations, exacerbation of epilepsy, upper respiratory infection, bronchospasm, exacerbation of bronchospasm, dyspnea, laryngitis, pneumonia, nosebleed, voice disorder, vesicular dermatitis, dermatitis, nail disease, photosensitivity reaction, itching, erythematous rash, papular rash, skin diseases, skin dryness, increased sweating, erythema multiforme, exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, eczema, lipoma, drug rash, arrhythmia, left ventricular hypertrophy, angina, unstable angina, coronary artery disease, heart failure, palpitations, tachycardia, aortic valve insufficiency, hematoma, sinus bradycardia, syncope, ventricular fibrillation, pulmonary embolism, cerebrovascular accident, peripheral gangrene, thrombophlebitis, vasculitis, deep vein thrombosis, cerebral hemorrhage, pneumonia, wound infection, gingivitis, herpes simplex, shingles, bacterial infection, fungal infection, soft tissue infection, viral infection, candidiasis, genital candidiasis, otitis media, breast tenderness, menopausal symptoms, fibrocystic breast disease, chest neoplasm, chest pain, dysmenorrhea, menstrual disorders, vaginal bleeding, vaginitis, prostate disorders, ovarian cysts, hearing loss, ear abnormalities, otalgia, deafness, abnormal liver function, elevated ALT, elevated AST, increased γ-GTP, increased ALP, positive urobilinogen, cholelithiasis, hepatitis, jaundice, liver failure, fulminant hepatitis, liver necrosis, increased serum sodium, increased serum potassium, elevated BUN, increased CPK, diabetes mellitus, hypercholesterolemia, hyperglycemia, hypokalemia, hyperkalemia, elevated NPN, increased creatinine, elevated alkaline phosphatase, weight gain, increased LDH, hypoglycemia, hyponatremia, bursa, arthralgia, arthropathy, skeletal abnormalities, myalgia, cervical tension, synovitis, tendinitis, myositis, fracture, tendon rupture, pain in the back, muscle rigidity, decreased hematocrit, increased hemoglobin, petechiae, nosebleed, thrombocytopathy, agranulocytosis, aplastic anemia, pancytopenia, leukopenia, folliculitis, contact dermatitis, injection site reactions, skin nodules, dysgeusia, albuminuria, cystitis, hematuria, dysuria, polyuria, nephrolithiasis, urinary incontinence, urinary tract infection, blurred vision, cataract, conjunctivitis, eye pain, glaucoma, ocular hemorrhage, retinal artery or vein occlusion, increased serum creatinine, increased β2-microglobulin, increased NAG, positive urinary hematuria, positive urinary protein, renal dysfunction, acute renal failure, interstitial nephritis, anaphylactic reaction, vasculitis, interstitial pneumonia, hepatitis, photosensitivity reaction, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, drug rash, acute generalized exanthematous pustulosis, exfoliative dermatitis, acute renal failure, hyponatremia, tubular interstitial nephritis, nephrotic syndrome, minimal change glomerulonephritis, menstrual disorders, female infertility

This medication should be stored in a tightly closed container to prevent air or moisture ingress, ideally at room temperature between 15°C and 30°C. Storing it this way helps maintain its effectiveness for a longer time.

Appearance

A white capsule filled with a white to pale yellow powder with a blue line on the upper and lower parts.

Package unit

30 capsules/bottle, 100 capsules/bottle