Meropenem Injection 1 g (Meropenem Hydrate)

Adult administration

As meropenem hydrate, administer 0.5 to 1 g (potency) per day, divided into 2 to 3 doses, infused via intravenous drip for over 30 minutes. For suspected infections in patients with pathogenic pneumonia, peritonitis, or neutropenia, administer 1 g (potency) via intravenous drip every 8 hours. For cystic fibrosis or meningitis, administer 2 g (potency) via intravenous drip every 8 hours.

Child administration

For bacterial meningitis in children over three months of age, infuse 40 mg per kg of body weight via intravenous drip every 8 hours for over 30 minutes, depending on the pathogen's susceptibility and the patient's condition.

This medication should not be administered to certain patients. For example, it should not be used in patients who have previously experienced shock due to this medication, patients taking valproate sodium, patients with allergies to this medication or its ingredients, and patients who have had severe allergic reactions to other carbapenem antibiotics or beta-lactam antibiotics. Additionally, caution should be exercised when administering this medication to patients with allergies, impaired renal function, epilepsy or central nervous system disorders, severely compromised liver function, elderly individuals, infants, and those with poor nutritional status. These patients may be at risk of increased drug concentrations leading to side effects, hence dose adjustments or changes in administration intervals may be necessary. This medication can rarely cause severe shock or anaphylactic reactions, skin rashes, blood abnormalities, liver or kidney dysfunction, severe diarrhea, central nervous system disorders, respiratory issues, or severe skin conditions, so if any adverse symptoms occur, administration should be discontinued immediately, and medical advice should be sought. To prevent the development of resistant bacteria, it is important to administer this medication for only the minimum duration necessary based on susceptibility testing. Patients' conditions should be closely monitored before and during treatment, and regular liver function tests should be conducted during prolonged use. This medication can interact with other drugs, so caution is especially required when used with valproate, antiepileptic drugs, hormonal contraceptives, and warfarin; blood concentration or coagulation state should be assessed frequently as necessary. The use of this medication should be carefully considered in women who are pregnant or may become pregnant, and it is recommended to avoid administration during breastfeeding. The safety of this medication in children, particularly infants under three months, has not been established, so caution is needed for use. Elderly patients may have decreased bodily function leading to a higher risk of side effects, so doses and intervals should be adjusted accordingly, while also considering the risk of bleeding due to vitamin K deficiency. This medication is administered only by intravenous injection and should be used rapidly after dissolution. It should be used within a specified time during storage, and changes in color do not affect the efficacy. Lastly, this medication may cause cross-reactivity with other beta-lactam antibiotics, so patients with a history of allergies to such medications must inform their healthcare provider.

Serious side effects

Hives, severe swelling (angioedema), chest tightness, difficulty breathing, cold sweat, pallor, shock, anaphylactic reaction, severe rash with high fever, blisters, skin sloughing, pain in mouth/eye mucosa, severe skin reactions (toxic epidermal necrolysis, Stevens-Johnson syndrome, DRESS syndrome, AGEP), shortness of breath or difficulty breathing, asthma attack, respiratory abnormalities with cough + fever, jaundice in the skin or eyes.

Mild side effects

• Discomfort
• taste disturbances
• wheezing
• dizziness
• diarrhea
• tinnitus
• sweating
• rash
• hives
• warmth

This medication should be stored in a sealed container to prevent air or moisture from entering, and it is safe to store at room temperature between 1°C and 30°C.

Appearance

A colorless and transparent vial filled with a white to light yellow crystalline powder.

Package unit

10 vials