Dimencare Tablet 10 mg (Donepezil Hydrochloride Monohydrate)

Adult dose

○ Adults : Administer 5 mg of donepezil hydrochloride once daily at bedtime. If sleep disturbances such as abnormal dreams, nightmares, or insomnia occur, taking this medicine in the morning may be considered. As donepezil concentrations reach steady state 15 days after administration and the frequency of adverse reactions may be affected by the rate of dose escalation, administer the 5 mg dose for 4～6 weeks. After evaluating the clinical response during this period, the dose may be increased to 10 mg. When increasing the dose to 10 mg daily, administer with caution for gastrointestinal adverse reactions. If administration of this medicine is discontinued, its effect gradually declines, and no rebound effect occurs following abrupt discontinuation. ○ Female patients aged 85 years or older with low body weight : Careful monitoring is required because adverse reactions occur frequently. Elderly women with low body weight should not exceed 5 mg daily.

Child dose

○ Children : There is no experience with use in children.

This medication contains the ingredient donepezil hydrochloride and is used for the improvement of symptoms of Alzheimer's type dementia. First, this drug should not be administered to certain patients. For example, individuals with an allergy to this drug or its components, women who are pregnant or may become pregnant, and patients with genetic metabolic issues such as lactose intolerance should not take this medication. Additionally, patients with heart disease, a history of peptic ulcers or who are taking non-steroidal anti-inflammatory drugs, patients with a history of asthma or obstructive pulmonary disease, patients with extrapyramidal disorders like Parkinson's disease, and those allergic to the yellow No. 5 dye in this drug should use it cautiously. Various adverse reactions may occur while taking this medication. Heart-related issues such as bradycardia, heart block, and myocardial infarction may arise, while gastrointestinal issues like peptic ulcers or gastrointestinal bleeding can occur. Neurologically, seizures, movement disorders, hallucinations, confusion, and musculoskeletal issues such as muscle pain or rhabdomyolysis should also be monitored. This medication can affect the ability to drive or operate machinery, so caution is advised during initial use or dose adjustments. Furthermore, this drug may interact with multiple medications. Particularly, when taken alongside drugs metabolized by the liver, its efficacy may change, so consultation with a doctor or pharmacist is advisable. Caution is also necessary when combined with medications that affect heart conduction or increase gastric acid secretion. Women who are pregnant or nursing are advised not to use this drug, and if necessary, the decision should be made after consulting a professional. Safety in children has not yet been confirmed, so it should not be used in this population. In case of overdose, severe nausea, vomiting, bradycardia, and respiratory depression may occur, requiring immediate medical attention, and atropine may be used as an antidote. Finally, this drug should be stored out of reach of children, and transferring it to another container is not advisable as it may negatively affect its quality.

• Syncope
• bradycardia
• heart block
• prolonged QT interval
• myocardial infarction
• heart failure
• peptic ulcer
• perforation of the duodenum
• gastrointestinal bleeding
• hepatitis

This medication should be stored in a sealed container to prevent air ingress, at a temperature between 1 and 30 degrees Celsius. Storing it this way will help maintain the drug's effectiveness over time.

Appearance

Yellow round film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle