Pavibsphbesostart Tablet 40 mg

Adult dosage

1. Adults Administer 40 mg or 80 mg once daily, regardless of meals. Because this medicine acts very rapidly, recheck the serum uric acid level after 2 weeks. The treatment goal is to reduce and maintain the serum uric acid level below 6 mg/dL(357 μmol/L). 2. Patients with renal impairment No dosage adjustment is necessary in patients with mild or moderate renal impairment. The safety and efficacy of this medicine have not been adequately evaluated in patients with severe renal impairment (creatinine clearance below 30mL/min). 3. Patients with hepatic impairment No special dosage adjustment is necessary in patients with mild or moderate hepatic impairment. Only limited information is available for patients with moderate hepatic impairment, and the efficacy and safety of this medicine have not been studied in patients with severe hepatic impairment (Child-Pugh Class C).

This medication may increase the risk of cardiovascular death in patients with cardiovascular diseases; therefore, it should be used cautiously in patients with a history of cardiovascular conditions. Patients with a history of allergic reactions to this medication or those currently taking the medications mercaptopurine or azathioprine should not use it. Patients with lactose intolerance or certain genetic metabolic disorders should also avoid use of this medication. Patients with liver diseases or thyroid dysfunction, as well as those with heart conditions, should undergo regular liver function tests and monitoring while using this medication. This medication may temporarily worsen gout attacks; therefore, it should not be initiated until gout attacks are resolved and should be used with other medications for prevention of attacks initially. If symptoms such as liver function abnormalities, weakness, or jaundice appear during treatment, consult a physician immediately and discontinue the medication if necessary. This medication may cause drowsiness or dizziness, so caution is advised when driving or operating machinery. This drug may interact with certain medications; therefore, notify your physician or pharmacist of any other medications you are taking. It is advisable for women who are pregnant or breastfeeding to avoid this medication, and its use is not recommended in children. In cases of overdose, as there is no specific antidote, it is important to receive symptomatic treatment.

Liver dysfunction, dizziness, diarrhea, headache, rash, nausea, fatigue, joint pain, limb pain, gout, muscle pain, pruritus, dyspnea, anemia, idiopathic thrombocytopenic purpura, leukocytosis, leukopenia, neutropenia, pancytopenia, splenomegaly, thrombocytopenia, angina, atrial fibrillation, atrial flutter, heart murmur, abnormal electrocardiogram, palpitations, bradycardia, tachycardia, hearing loss, tinnitus, vertigo, blurred vision, abdominal distension, abdominal pain, constipation, dry mouth, dyspepsia, flatulence, increased bowel movements, gastritis, gastroesophageal reflux disease, gastrointestinal discomfort, gum pain, hematemesis, hyperacidity, passage of blood in stool, oral ulcer, pancreatitis, gastric ulcer, vomiting, weakness, chest pain, chest discomfort, edema, emotional disturbances, walking difficulties, influenza-like symptoms, pain, thirst, cholelithiasis, diabetes insipidus, fatty liver, hepatitis, hepatomegaly, hypersensitivity, herpes zoster, anorexia, decreased appetite, increased appetite, dehydration, diabetes mellitus, hypercholesterolemia, hyperlipidemia, hypertriglyceridemia, hypokalemia, weight loss, weight gain, arthritis, joint stiffness, joint swelling, muscle cramps, muscle fasciculation, muscle stiffness, muscle weakness, musculoskeletal pain, muscle rigidity, taste changes, balance disorders, cerebrovascular accident, Guillain-Barré syndrome, headache, partial paralysis, sensory loss, olfactory loss, heat stroke, drowsiness, mental disorders, migraine, sensory disturbances, somnolence, transient ischemic attack, tremors, anxiety, depression, insomnia, excitability, decreased libido, irritability, panic attacks, personality changes, hematuria, nephrolithiasis, pollakiuria, proteinuria, renal failure, renal insufficiency, urgency of urination, incontinence, breast pain, erectile dysfunction, gynecomastia, bronchitis, cough, dyspnea, epistaxis, nasal dryness, excessive sinus secretion, pharyngeal edema, airway obstruction, sneezing, throat irritation, upper respiratory infection, alopecia, angioedema, dermatitis, skin rash, petechiae, eczema, hair discoloration, abnormal hair growth, hyperhidrosis, skin peeling, petechial hemorrhages, photosensitivity, pruritus, purpura, skin discoloration, pigmentary changes, skin lesions, axillary hyperhidrosis, urticaria, flushing, facial flushing, hypertension, hypotension, activated partial thromboplastin time prolongation, increased creatinine, decreased bicarbonate, increased sodium, abnormal EEG, increased glucose, increased cholesterol, increased triglycerides, increased amylase, increased potassium, increased thyroid-stimulating hormone, decreased platelets, decreased hematocrit, decreased hemoglobin, increased MCV, decreased red blood cells, increased creatinine, increased blood urea, increased blood urea nitrogen ratio, increased CPK, increased ALP, increased LDH, increased PSA, increased urine output, decreased urine output, decreased lymphocyte count, decreased neutrophil count, increased white blood cell count, decreased white blood cell count, abnormal coagulation tests, increased low-density lipoprotein, prolonged prothrombin time, urinary casts, positive urinary leukocytes, positive urinary protein, contusion, Stevens-Johnson syndrome, toxic epidermal necrolysis, acute anaphylactic reaction, shock, severe allergic reaction, hypersensitivity reactions, eosinophilia, drug reactions with systemic symptoms, liver failure, jaundice, hepatic impairment, agranulocytosis, rhabdomyolysis

This medication should be stored in a tightly closed container to prevent air or moisture exposure. Additionally, it should be stored at room temperature, ideally between 1°C and 30°C, avoiding excessively hot or cold conditions.

Appearance

White to light yellow round film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle