Roxifene Tablet (Roxifene Hydrochloride)

Adult dose

Administer 60 mg orally once a day as Roxifene Hydrochloride.

This medication can increase the risk of thromboembolism, which is the formation of blood clots in blood vessels. Therefore, it should be administered cautiously to patients at risk for thrombosis, and if immobility occurs, the medication should be discontinued. Since this medication is primarily metabolized in the liver, patients with impaired liver function should avoid it or use it very cautiously. It is not approved for use in premenopausal women, and pregnant women or those who may become pregnant should not take it. Additionally, breastfeeding women should also avoid taking this medication. It should not be used in patients with cardiovascular diseases or for cardiovascular prevention. This medication is not recommended to be used in conjunction with other systemic estrogen preparations. Careful monitoring of bleeding risks should be done when used with anticoagulants. This medication contains lactose, thus individuals with lactose intolerance should not use it. While taking this medication, symptoms such as facial flushing, leg cramps, peripheral edema, and cold symptoms may appear. If unexpected uterine bleeding occurs, one should seek professional diagnosis immediately. It should be used with caution in patients with a history of breast cancer, and if any abnormal symptoms occur in the breast during treatment, tests should be performed. This medication is strictly for the treatment and prevention of osteoporosis in postmenopausal women and should not be administered to men or children. An overdose may result in leg cramps, dizziness, and other symptoms, so caution is advised. This medication should be kept out of the reach of children and should not be transferred to other containers.

Serious side effects

• Deep vein thrombosis
• pulmonary embolism
• retinal vein thrombosis
• venous thromboembolism
• superficial venous thrombophlebitis
• retinal vein occlusion
• stroke
• death related to deep vein thrombosis
• thrombocytopenia
• hypertension

Mild side effects

Vasodilation (flushing), leg cramps, cold symptoms, peripheral edema, slight decrease in platelet count, moderate increase in AST and ALT, gallstones, nausea, vomiting, abdominal pain, indigestion, hypertension, headache, rash, breast symptoms (pain, swelling, tenderness), facial flushing, vaginal bleeding, facial swelling, heartburn, constipation, itching, palpitations, fever, weakness, sweating, myalgia, insomnia, perineal pain, weight gain, arthritis, rheumatic-like symptoms.

This medication should be stored in a tightly sealed container to prevent air infiltration, ideally in a cool place between 15 to 30 degrees Celsius. This way, the effectiveness of the medication can be maintained for a longer period.

Appearance

White oval film-coated tablet

Package unit

28 tablets (14 tablets/PTPX2)