Meropenem Injection 1g (Meropenem Hydrate)

Adult administration

For meropenem hydrate, administer 0.5 to 1 g daily (potency) divided into 2 to 3 doses via intravenous infusion spread over at least 30 minutes. For suspected infections in patients with pathogenic pneumonia, peritonitis, or neutropenia, administer 1 g (potency) every 8 hours intravenously. For cystic fibrosis and meningitis, administer 2 g (potency) every 8 hours intravenously.

Child administration

For bacterial meningitis in children over 3 months, administer 40 mg per kg of body weight every 8 hours via intravenous infusion spread over at least 30 minutes, depending on the pathogen's susceptibility and the patient’s condition.

This medication should not be administered to patients who have previously experienced shock due to this medication. Patients currently taking sodium valproate should be cautious, as using this drug together may reduce the effect of sodium valproate and lead to seizures. Avoid use in patients with allergies to this medication or its components or those who have had severe allergic reactions to other carbapenem or beta-lactam antibiotics. Patients with allergic tendencies or frequently experience bronchial asthma, rash, etc., and those with impaired renal function should have dose adjustments and monitoring when using this medication. It should also be administered with caution to patients with epilepsy or central nervous system disorders and severe liver dysfunction. Elderly individuals, infants, and those with poor nutritional status require special monitoring during the use of this medication. This medication can rarely cause various side effects, including shock, anaphylaxis, skin rashes, blood disorders, liver and kidney dysfunction, gastrointestinal disturbances, central nervous system abnormalities, respiratory and cardiovascular issues, thus it is important to closely monitor the patient's condition during administration. If skin rashes or signs of liver dysfunction appear, discontinue the drug immediately and seek appropriate treatment. To prevent bacterial resistance, this drug should only be used for the minimum necessary duration based on susceptibility testing, and the patient's condition and test results should be carefully checked before and during administration. It is advisable to check the patient's history of allergies and skin reactions before administration to prevent shock and to observe the patient post-administration under stable conditions. Other medications may interact when used concurrently, so any current medications must be disclosed, and drug levels may need to be checked through blood tests if necessary. In pregnant or breastfeeding women, safety has not been fully established, and this medication should only be used when the therapeutic benefits outweigh the risks; avoidance during breastfeeding is recommended. Safety and efficacy in infants under 3 months have not been established, and caution is needed for use. Elderly patients may have decreased bodily functions, making them more susceptible to side effects, thus careful monitoring of dosage and intervals is necessary. This medication is intended for intravenous administration only, should be used as soon as possible after reconstitution, and should be stored following temperature and time guidelines. Finally, this medication may cross-react with some beta-lactam antibiotics, so any prior allergic reactions to such drugs must be reported to healthcare providers.

Serious side effects

Shock, anaphylaxis, hives, angioedema, severe skin reactions (toxic epidermal necrolysis, Stevens-Johnson syndrome, DRESS syndrome, erythema multiforme, acute generalized exanthematous pustulosis), severe colitis (pseudomembranous colitis), jaundice, liver failure, fulminant hepatitis, acute renal failure, asthma, difficulty breathing, seizures, altered consciousness, severe edema, hypertension, severe rash with fever, blisters, skin peeling, mucosal lesions in mouth/eyes.

Mild side effects

• Rash
• hives
• feeling of heat
• erythema
• itching
• fever
• redness
• systemic flushing
• angioedema
• oral dysesthesia

Store this medication in sealed containers to prevent air and moisture exposure and keep at a temperature between 1 to 30 degrees Celsius.

Appearance

A colorless, transparent vial filled with crystalline powder that is white to light yellow.

Package unit

10 vials