Febuxostat 80 mg (Febuxostat)

Adult dosage

1. Adults This drug is administered once daily at a dose of 40mg or 80mg, with or without food. Since this drug acts very rapidly, recheck serum uric acid levels after 2 weeks. The treatment goal is to lower and maintain serum uric acid levels below 6 mg/dL(357 μmol/L). 2. Patients with renal impairment No dose adjustment is necessary in patients with mild or moderate renal impairment. The safety and efficacy of this drug have not been adequately evaluated in patients with severe renal impairment (creatinine clearance below 30mL/min). 3. Patients with hepatic impairment No special dose adjustment is necessary in patients with mild or moderate hepatic impairment. Only limited information is available for patients with moderate hepatic impairment, and the efficacy and safety of this drug have not been studied in patients with severe hepatic impairment (Child Pugh class C).

This medication may increase the risk of cardiovascular mortality when administered to patients with cardiovascular diseases. Therefore, patients with a history of heart or cerebrovascular disorders should use it cautiously. Patients with an allergy to any of the ingredients in this medication or who are taking specific drugs such as mercaptopurine and azathioprine should not use it. Patients with certain genetic metabolic disorders like lactose intolerance should also refrain from taking this medication. Patients with liver diseases or thyroid abnormalities should regularly check liver and thyroid function while taking this medication, and patients with heart diseases or heart failure should be cautious as well. Patients taking the specific medication theophylline should exercise caution when combining it with this medication, and organ transplant recipients should also use this medication cautiously. This medication should not be initiated during an acute gout attack, and initial administration may temporarily worsen gout attacks, so appropriate preventive measures are necessary. If symptoms of liver dysfunction (such as fatigue, loss of appetite, jaundice, etc.) appear, the medication should be discontinued, and tests should be carried out, adjusting medication based on liver function test results is necessary. This medication can cause side effects like drowsiness and dizziness, so care should be taken when driving or operating dangerous machinery. Severe allergic reactions or hypersensitivity reactions can rarely occur, and if these symptoms appear, administration should be stopped immediately. This medication may interact with various other drugs, so patients must inform healthcare providers of any other medications they are taking. Pregnant or breastfeeding women should avoid this medication, and it is not recommended for children under 18 years of age due to a lack of experience in pediatric use. In the case of overdose, no specific antidote exists, and treatment based on symptoms is required. This medication should be kept out of reach of children, and no special storage conditions are required.

Liver dysfunction, dizziness, diarrhea, headache, rash, nausea, fatigue, arthralgia, limb pain, gout, myalgia, pruritus, dyspnea, anemia, idiopathic thrombocytopenic purpura, leukocytosis, leukopenia, neutropenia, pancytopenia, splenomegaly, thrombocytopenia, angina, atrial fibrillation, atrial flutter, heart murmur, ECG abnormalities, palpitations, bradycardia, tachycardia, hearing loss, tinnitus, vertigo, blurred vision, abdominal distension, abdominal pain, constipation, dry mouth, dyspepsia, flatulence, increased bowel movements, gastritis, gastroesophageal reflux disease, gastrointestinal discomfort, gum pain, hematemesis, hyperchlorhydria, passage of bloody stools, oral ulcer, pancreatitis, gastric ulcer, vomiting, asthenia, chest pain, chest discomfort, edema, emotional disturbances, gait disturbances, flu-like symptoms, mass, pain, thirst, cholelithiasis, diabetes mellitus, fatty liver, hepatitis, hepatomegaly, hypersensitivity, shingles, anorexia, decreased appetite, increased appetite, dehydration, diabetes, hypercholesterolemia, hyperlipidemia, hypertriglyceridemia, hypokalemia, weight loss, weight gain, arthritis, joint stiffness, joint edema, muscle cramps, muscle fasciculation, muscle spasm, muscle weakness, musculoskeletal pain, muscle rigidity, taste changes, balance disturbances, cerebrovascular accident, Guillain-Barré syndrome, headache, partial paralysis, sensory loss, olfactory reduction, cerebral infarction, somnolence, mental disorder, migraine, sensory disturbances, drowsiness, transient ischemic attack, tremors, agitation, anxiety, depression, insomnia, excitability, decreased libido, neuroexcitation, panic attack, personality changes, hematuria, nephrolithiasis, frequent urination, proteinuria, renal failure, renal insufficiency, urinary urgency, urinary incontinence, mastalgia, erectile dysfunction, gynecomastia, bronchitis, cough, dyspnea, epistaxis, nasal dryness, excessive sinus secretion, pharyngeal edema, airway congestion, sneezing, throat irritation, upper respiratory infection, alopecia, vascular edema, dermatitis, skin eruption, petechiae, eczema, hair discoloration, abnormal hair growth, hyperhidrosis, skin peeling, petechial hemorrhage, photosensitivity, pruritus, purpura, skin discoloration, pigmentation changes, skin lesions, axillary hyperhidrosis, urticaria, flushing, facial flushing, hypertension, hypotension, prolonged activated partial thromboplastin time, increased creatinine, decreased bicarbonate, increased sodium, abnormal EEG, increased glucose, increased cholesterol, increased triglycerides, increased amylase, increased potassium, increased thyroid-stimulating hormone, decreased platelets, decreased hematocrit, decreased hemoglobin, increased MCV, decreased red blood cells, increased creatinine, increased blood urea, increased blood urea/creatinine ratio, increased CPK, increased ALP, increased LDH, increased PSA, increased urine output, decreased urine output, decreased lymphocyte count, decreased neutrophil count, increased white blood cell count, decreased white blood cell count, abnormal coagulation tests, increased low-density lipoprotein, prolonged prothrombin time, urine casts, positive urine leukocytes, positive urine protein, contusion, Stevens-Johnson syndrome, toxic epidermal necrolysis, acute anaphylactic reaction, shock, severe allergic reaction, hypersensitivity reactions, eosinophilia, drug reactions associated with systemic symptoms, liver failure, jaundice, liver impairment, agranulocytosis, rhabdomyolysis

This medication should be stored in a tightly sealed container to prevent exposure to air and moisture, and it is recommended to store it at room temperature between 1 and 30 degrees Celsius. Storing it this way helps maintain the medication's effectiveness for a longer period.

Appearance

Pale yellow to yellow rectangular film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle