Piotomin Tablets 15/850 milligrams

Adult dosage

1 tablet daily, taken with meals. The dosage should be individualized within the range not exceeding pioglitazone 30mg and metformin 2500mg. Dosage should be gradually adjusted based on the evaluation of therapeutic response, and the maximum dosage should not be increased for patients with renal impairment, elderly patients, frail patients, and those with nutritional deficiencies.

This medication consists mainly of two components, the first of which is a drug that assists in blood sugar control. However, during the use of this medication, there is a very rare possibility of developing a serious condition called lactic acidosis, which occurs when there is excessive accumulation of lactic acid in the body. Lactic acidosis can occur more frequently in patients with impaired kidney function or those with issues related to the heart or lungs, or in patients with dehydration or infections, so caution is needed. Additionally, patients with liver dysfunction or those who consume excessive amounts of alcohol should avoid taking this medication. Initial symptoms of lactic acidosis may include fatigue, muscle pain, difficulty breathing, and abdominal pain; if such symptoms occur, immediate consultation with a physician is necessary. The second component is a drug that enhances the effect of insulin, and in some patients, the risk of worsening heart conditions such as heart failure may increase, so this medication should not be used in patients with severe heart conditions. This medication may cause edema due to fluid retention, and weight gain may occur, so it's important to regularly monitor the body's condition. Moreover, patients with a history of bladder cancer should carefully consider the risks of cancer recurrence associated with the use of this medication. This medication is not administered to patients with impaired kidney function, severe heart failure, active bladder cancer, pregnant or nursing women, or patients with certain genetic issues. Caution is also needed for patients before and after surgery, those with acute infections, or those in a state of malnutrition. While taking this medication, liver and kidney functions should be regularly monitored, and blood tests are needed as vitamin B12 deficiency may occur. Additionally, there is a risk of hypoglycemia, so care should be taken, especially in cases of irregular meals, excessive exercise, or use of other blood glucose-lowering agents. Alcohol may interact with this medication and increase risks, so it is advisable to avoid drinking while on treatment. When undergoing surgery or imaging examinations with contrast agents, it is essential to inform the physician about the use of this medication to decide on whether to discontinue its use. Finally, when administering this medication to elderly patients, kidney function should be closely monitored, and dosage should be adjusted accordingly; if any unusual symptoms or side effects occur, immediate consultation with a physician is necessary.

Serious side effects

Severe lactic acidosis, hypoglycemia, acute kidney function deterioration, cardiopulmonary disease, sepsis, liver abnormalities (jaundice), severe allergic reactions, severe heart failure, worsening of congestive heart failure, cardiovascular abnormalities, acute coronary syndrome, serious cardiac adverse reactions, acute myocardial infarction, acute kidney failure, severe infections, low blood pressure, resistant bradyarrhythmia, severe neurological symptoms (severe headache, seizures, altered consciousness, visual disturbances, paralysis), difficulty breathing.

Mild side effects

• Upper respiratory tract infections
• diarrhea
• nausea
• headaches
• urinary tract infections
• sinusitis
• dizziness
• lower limb edema
• weight gain
• muscle pain

This medication should be stored in a tightly sealed container to prevent exposure to air or moisture. It is best to keep it at room temperature between 1 and 30 degrees Celsius.

Appearance

White to grayish-white rectangular film-coated tablets

Package unit

30 tablets (10 tablets/PTP*3)