Rinaton M 2.5/1000 mg

Adult dose

The dosage of this medication is to administer 2.5 mg of linagliptin and 1000 mg of metformin orally twice daily with meals. - For patients who are initiating metformin: initial dose of 2.5/500 mg taken twice daily, one tablet at a time, can be increased to 2.5/1000 mg. - In cases where adequate blood glucose control cannot be achieved with metformin monotherapy: combine with linagliptin 2.5 mg taken twice daily.

This medication can cause a rare but serious side effect called lactic acidosis, so it should not be used especially in patients with impaired kidney function or those with heart and liver diseases. Patients allergic to any ingredients in this medication, or those with type 1 diabetes or diabetic ketoacidosis should not take it. It is advisable not to use this medication in cases of acute infections, dehydration, severe trauma, shock, or any conditions that may lead to rapid deterioration of kidney function. Women who are pregnant or breastfeeding should not take this medication, and it is also advisable to avoid its use if planning a pregnancy. The risk of hypoglycemia exists, so caution should be exercised for symptoms of low blood sugar when used with other hypoglycemic agents such as sulfonylureas or insulin, and dosage adjustments may be necessary. Elderly patients or those taking medications that may affect kidney function should undergo regular kidney function tests. During treatment with this medication, symptoms of acute pancreatitis or skin disorders such as bullous pemphigoid may occur, and should abdominal pain or skin rash arise, immediate consultation with a physician is required. Since there may be a decrease in vitamin B12 levels, regular blood testing for vitamin B12 status is advisable with prolonged use. This medication can be taken irrespective of meal timing; however, it is recommended to be taken during or after meals to minimize gastrointestinal discomfort. Interactions between this medication and others may occur, so it is essential to inform the physician or pharmacist of any other medications being taken. Due to the risk of lactic acidosis, this medication should be discontinued immediately and medical consultation sought in case of severe vomiting, diarrhea, or other signs of dehydration. This medication should be temporarily discontinued before surgery or radiological testing and resumed only after kidney function has recovered. Children and those under 10 years old should not use this medicine due to insufficient data on its safety and efficacy in this age group. Although no studies have been conducted regarding its effects on driving or machinery operation, caution is advised due to the possibility of hypoglycemic symptoms. In cases of overdose, gastrointestinal symptoms or lactic acidosis may occur, and appropriate medical treatment should be sought immediately. This medication should be stored in a sealed container, away from moisture and direct sunlight, and should not be transferred to another container.

Serious side effects

Urticaria, angioedema, lactic acidosis, pancreatitis, bullous pemphigoid, liver dysfunction (abnormal liver function tests, hepatitis), severe allergic reactions, severe skin adverse reactions (rash, erythema), difficulty breathing, asthma, severe edema, acute kidney injury, acute myocardial infarction, unstable angina, cardiac arrest, acute cholangitis, acute cholecystitis, cholangitis, gallstones, acute pyelonephritis, sepsis, severe and disabling complications

Mild side effects

• Nasopharyngitis
• hypersensitivity
• angioedema
• hypoglycemia
• taste disturbance
• cough
• decreased appetite
• diarrhea
• constipation
• nausea

This medication is sensitive to air and moisture, and must be stored in a sealed container. It is also important to keep it at room temperature between 1 and 30 degrees Celsius to maintain its effectiveness.

Appearance

Bright pink, oval, film-coated tablet with both sides convex

Package unit

60 tablets (10 tablets / PTP) x 6