Meknaltime Ropepenem Injection 500 mg (Meropenem Hydrate)

Adult administration

As Meropenem hydrate, administer 0.5 to 1 g (potency) daily in 2 to 3 divided doses via slow intravenous infusion lasting more than 30 minutes. For suspected infections in patients with pathogenic pneumonia, peritonitis, and neutropenia, administer 1 g (potency) via slow intravenous infusion every 8 hours. For cystic fibrosis and meningitis, administer 2 g (potency) via slow intravenous infusion every 8 hours.

Child administration

For bacterial meningitis in children over 3 months, administer 40 mg per kg body weight every 8 hours via slow intravenous infusion lasting more than 30 minutes. Additionally

This medication should not be used in patients who have previously experienced severe allergic reactions or anaphylactic shock to this drug or its components. Additionally, this medication cannot be used in patients taking valproate sodium, as it might lower the blood concentration and increase the risk of seizure recurrence. Patients who have had severe allergic reactions to other carbapenem or beta-lactam antibiotics should also not receive this medication. Individuals with a history of allergies, such as bronchial asthma or rashes, should use this medication with caution. Patients with impaired kidney function may retain the drug longer, leading to central nervous system side effects, and therefore dosage adjustments or extended administration intervals are necessary. Caution is also advised in patients with seizure disorders or central nervous system diseases, as seizures or consciousness impairment may occur when using this medication. Patients with very poor liver function may have exacerbated liver conditions, so administration should be done cautiously. Elderly patients may experience side effects more frequently due to decreased physiological functions; therefore, dose adjustments and careful monitoring are necessary. Patients who have difficulty swallowing or have poor nutritional status should be monitored closely for the risk of bleeding due to vitamin K deficiency. In infants under 3 months, the safety and efficacy are not established, thus caution is necessary. This medication can rarely cause shock or anaphylaxis during administration, hence sufficient history-taking and observation prior to administration are needed, and if symptoms occur, administration should be stopped immediately, and appropriate measures should be taken. If allergic symptoms such as skin rashes, hives, or itching occur, medication should be discontinued immediately. Regular blood tests are needed as leukopenia, anemia, or thrombocytopenia may occur. Liver function tests should be performed regularly as liver dysfunction or symptoms of acute hepatitis, jaundice may appear. Regular kidney function tests are also necessary as kidney function impairment may occur; medication should be stopped if abnormalities are found. Pseudomembranous colitis, which can present with severe diarrhea and abdominal pain, can rarely occur; therefore if diarrhea symptoms develop, immediate consultation with medical professionals is required. Central nervous system side effects like seizures or consciousness impairment may occur, especially in patients with kidney disease or neurological disorders, requiring extra caution. Respiratory adverse reactions such as asthma, pneumonia, and pulmonary edema have rarely been reported; rapid action is required in case of symptoms. Serious skin reactions such as Stevens-Johnson Syndrome and toxic epidermal necrolysis can occur rarely, and medication should be stopped immediately if any skin abnormalities develop. Disruptions in normal flora can lead to conditions like stomatitis or candidiasis. There may be tendencies for bleeding due to vitamin K deficiency, requiring observation of bleeding symptoms. Cardiovascular adverse reactions such as heart failure, cardiac arrest, tachycardia, and hypotension have been reported and should be closely monitored. Neuropsychiatric side effects such as insomnia, confusion, and dizziness may occur, necessitating caution. Inflammation, pain, and swelling may occur at the injection site; the site should be monitored closely. This medication can interact with other drugs, so consultation with healthcare providers about concomitant medications is essential, especially when used with anticonvulsants, hormone medications, and anticoagulants, requiring careful monitoring of blood concentrations. Pregnant women or women who may become pregnant should use this medication only after consulting with a doctor when the benefits outweigh the risks. Breastfeeding women should avoid this medication as it may be excreted in breast milk. After preparation, it should be used as soon as possible, and when stored, it should be used within 6 hours at room temperature or within 24 hours when refrigerated. This medication should only be administered intravenously and must check if there has been hypersensitivity to penicillin or cephalosporin medications.

Serious side effects

Shock, anaphylactic reactions, hives, severe swelling (edema), tightness in the chest, difficulty breathing, cold sweat, pallor, severe allergic reactions, high fever with severe rashes, blisters, skin peeling, oral/ocular mucosal pain, severe skin reactions, difficulty breathing or shortness of breath, asthma attacks, respiratory issues accompanying cough + fever, jaundice (yellowing of skin or eyes), generalized fatigue, liver

Mild side effects

• Oral abnormalities
• dizziness
• changes in bowel movements
• tinnitus
• sweating
• rashes
• warmth
• redness
• itching
• fever

This medication should be stored in a sealed container that prevents air ingress and is best kept at a temperature between 1°C and 30°C. This storage will help safely maintain the effectiveness of the medication.

Appearance

A colorless and transparent vial filled with white to pale yellow crystalline powder.

Package unit

10 vials