Bonisense Injection (Pre-filled) (Sodium Hyaluronate)

Adult administration

Typically, 1 tube is injected into the knee joint or shoulder joint once a week for 3 weeks in adults. The frequency of administration can be adjusted as appropriate based on symptoms.

This medication should not be used in patients with a history of allergic reactions to its ingredients. Caution should be exercised in patients with allergies to other medications or those with liver dysfunction or a history of liver diseases. Additionally, if there is a skin condition or infection at the injection site, the condition should be assessed before administering this medication. Severe shock symptoms may occur during the use of this medication, so patient status should be closely monitored during administration. If swelling of the face or around the eyes, rashes, hives, or itching appear as allergic symptoms, use should be stopped immediately and appropriate treatment sought. Temporary pain, swelling, redness, warmth, and pressure may occur at the injection site, so these symptoms should be reported to the medical staff. Occasionally, symptoms such as nausea, vomiting, and fever may also appear, requiring attention. If there is severe inflammation in the joint, it is advisable to use this medication after the inflammation subsides, and stabilizing the area after administration can be helpful. This medication should be injected accurately into the joint, and care should be taken to avoid leakage of the drug outside the injection site, as it may cause pain. Aseptic conditions must be maintained during administration, and if symptoms do not improve, it should be administered a maximum of three times and then discontinued. If there is a significant accumulation of joint fluid, it is advisable to remove some fluid before administering the medication, if necessary. This medication is not to be used for intravenous administration or eye-related treatments, and a 22–23 gauge needle is appropriate. Additionally, contact with certain disinfectants may cause the medication to precipitate, so such substances should be avoided. Women who are pregnant or may become pregnant should use this medication cautiously only when the benefits outweigh the risks, and nursing mothers should avoid breastfeeding during treatment. The safety of this medication has not been established in children, so it should only be used cautiously when absolutely necessary. Elderly individuals may have decreased bodily function, so special care is needed during use.

Serious side effects

Shock symptoms

Mild side effects

Swelling (facial, eyelid, etc.), facial flushing, rash, hives, itching, pain (mainly transient pain after administration), swelling, erythema, warmth, severe localized pressure, nausea, vomiting, fever

This medication should be stored in a sealed container to prevent exposure to air or moisture, and it is best to store it at room temperature between 1 to 30 degrees Celsius. This way of storage helps to maintain the efficacy of the medication for a long time.

Appearance

An injection filled with a colorless, transparent, viscous liquid contained in a colorless, transparent glass tube sealed with rubber stoppers at both ends (part of the pre-filled syringe system)

Package unit

2ml/tube x 3