J-Doxycycline Tablets (Doxycycline Hydrate)

Adult dose

○ Adults: The initial dose of doxycycline is 100 mg (potency) orally every 12 hours. The maintenance dose is 100 mg (potency) per day, administered in 1 ∼ 2 divided doses. ○ In severe infections, administer the initial dose every 12 hours. This medication should be continued for an additional 24 ～ 48 hours after symptoms subside and the fever resolves. For streptococcal infections, continue treatment for at least 10 days to prevent the development of rheumatic fever or glomerulonephritis. The dose may be adjusted appropriately according to age and symptoms.

Child dose

○ Adolescents aged 12 years and older: For those weighing 45 kg or less, the initial dose is 4 mg (potency) per kg of body weight per day, administered orally in 2 divided doses. The maintenance dose is 2 mg (potency) per kg of body weight per day, administered in 1 ∼ 2 divided doses. ○ Adolescents aged 12 years and older: For those weighing more than 45 kg, administer the adult dose.

This drug can cause diarrhea and colitis, which are induced by the bacterium Clostridium difficile. Symptoms may range from mild diarrhea to severe colitis, so it’s important to inform medical personnel if you experience diarrhea after taking the medication. Serious skin reactions may also occur; if you notice severe redness or peeling of the skin, you should discontinue use immediately and seek medical advice. Individuals allergic to this medication or with a hypersensitivity to tetracycline class drugs, pregnant or breastfeeding women, and children under the age of 12 should not take this medication. Special caution is needed for children and pregnant women as they may experience tooth discoloration or growth disturbances. Patients with severely impaired kidney or liver function, those with certain genetic metabolic abnormalities, or those with myasthenia gravis should consult with a physician before using this medication. This drug increases sensitivity to sunlight, making the skin more susceptible to burns; therefore, it is advisable to avoid direct sunlight or UV exposure while taking it and to use sunscreen. Additionally, be cautious about drug interactions during treatment, as taking certain antacids or iron and calcium preparations together may reduce the effectiveness, hence dosages should be spaced accordingly. Pregnant or breastfeeding women should avoid using this medication, particularly in the later stages of pregnancy as it may affect fetal bone development and tooth growth. Long-term use of this medication requires regular testing of liver, kidney, and hematopoietic functions, and if there are any abnormal symptoms, immediate consultation with healthcare personnel is necessary. In case of overdose, symptoms such as vomiting, nausea, and damage to the liver and kidneys can occur, so strict adherence to the recommended doses is essential, and any unusual symptoms should lead to immediate hospital visit. When taking the medication, it should be taken with plenty of water while standing or sitting to reduce the risk of esophageal irritation or ulceration. Finally, it should be stored out of reach of children to prevent misuse.

Diarrhea, colitis, exfoliative dermatitis, erythema multiforme, mucocutaneous syndrome, toxic epidermal necrolysis, drug reactions accompanied by eosinophilia and systemic symptoms, hemolytic anemia, neutropenia, thrombocytopenia, hypersensitivity, anaphylactic shock, angioedema, exacerbation of systemic lupus erythematosus, pericarditis, serum sickness, hypotension, dyspnea, tachycardia, peripheral edema, urticaria, microscopic brown discoloration of the thyroid gland, decreased appetite, headache, benign intracranial hypertension, protruding of the umbilical stump, tinnitus, flush, nausea, vomiting, dyspepsia, pancreatitis, pseudomembranous colitis, esophageal ulcer, esophagitis, enterocolitis, perianal genital inflammatory lesions, dysphagia, abdominal pain, glossitis, tooth discoloration, hepatotoxicity, hepatitis, abnormal liver function, photosensitivity reaction, rash, exfoliative dermatitis, phototoxic nail peeling, arthralgia, myalgia, increased BUN, anemia, granulocytopenia, atypical lymphocytes, lymphocytopenia, lymphadenopathy, blood coagulation disorder, anaphylactic reaction, fever, paresthesia, anxiety, agitation, severe colitis with bloody stools, loose stools, stomatitis, sore throat, black hairy tongue, hoarseness, jaundice, nail peeling, changes in nail color, arthritis, kidney damage, interstitial nephritis, acute kidney failure, oliguria, hematuria, visual disturbances, papilledema of the optic nerve head, decreased and loss of smell and taste, vitamin K deficiency, vitamin B group deficiency symptoms, facial, tongue, and laryngeal swelling, yellow urine, reduced glucosuria, liver and renal parenchyma damage, esophagitis, esophageal ulcer, anaphylactic reaction

This medication should be stored in a tightly closed container to avoid exposure to air and light. It is best kept in a cool, dark place at room temperature between 1 and 30 degrees Celsius.

Appearance

Green round tablets

Package unit

30 tablets/bottle, 100 tablets/bottle, 300 tablets/bottle