Glymax Tablet 4 mg (Glimepiride)

Adult dose

Adjust individually for each patient. Swallow without chewing with more than 1/2 cup of water. Administer orally once daily, before breakfast or right before the first meal. For monotherapy, the initial dosage is 1 mg of glimepiride taken once daily, gradually increasing by 1 mg at intervals of 1-2 weeks. Generally, it is administered up to a maximum of 4 mg, and if necessary, it can be increased to 6 mg or 8 mg.

This medication is not used in patients with insulin-dependent diabetes, diabetic ketoacidosis, or those in a coma. Moreover, it should not be administered in cases of allergy to this medication or to sulfonylureas or sulfonamides. There is no experience with use in patients with severe liver or kidney dysfunction; therefore, in such cases, switching to insulin therapy is advisable. Women who are pregnant or may become pregnant, as well as breastfeeding women, should not take this medication. In patients with severe infections, before and after surgery, or those with severe trauma, insulin therapy is recommended. Patients with gastrointestinal disturbances such as diarrhea or vomiting may not absorb food properly, increasing the risk of hypoglycemia, so caution is warranted. This medication contains lactose and should not be given to patients with genetic issues such as galactose intolerance, lactase deficiency, or glucose-galactose malabsorption. At the start of therapy, there is a higher risk of hypoglycemia; thus, especially elderly patients, those with poor nutritional status, irregular meals, and those who consume alcohol frequently should monitor their blood sugar closely. Patients with poor kidney or liver function, those with endocrine disorders, and those taking other medications may also have an increased risk of hypoglycemia and should be cautious. This medication can induce hypoglycemia, with symptoms such as headache, extreme hunger, nausea, fatigue, anxiety, confusion, dizziness, drowsiness, and decreased consciousness. If hypoglycemia is severe, it may lead to loss of consciousness or coma, so immediate treatment is required when symptoms appear. Transient visual disturbances, gastrointestinal disturbances, liver function abnormalities, blood abnormalities, and allergic reactions may occur infrequently, and if abnormal symptoms appear, you should consult a doctor. It is important to have regular meals, exercise, and manage weight while taking this medication, and it is advisable to always have foods containing sugar prepared to prevent hypoglycemic symptoms. When receiving treatment from other doctors or pharmacists, you must inform them that you are currently taking this medication, and in situations of stress such as surgery or infection, insulin therapy may need to be switched. After taking the medication, regular monitoring of blood sugar and urine tests should be conducted to check the drug's effectiveness and side effects. This medication can affect driving or operating machinery; therefore, caution is necessary when hypoglycemic symptoms are present. Since this medication is metabolized in the liver, caution must be exercised when taken with other medications that affect liver function, as some drugs may increase or decrease the blood sugar-lowering effect of this medication. Women who are pregnant or breastfeeding should not take this medication and should switch to insulin therapy if necessary. The safety and efficacy in pediatric patients have not been established, so it is not to be used in those under 18 years of age. Elderly patients may need dose adjustments due to delayed drug excretion from declining kidney function. In the case of overdose, severe hypoglycemia may occur, requiring immediate emergency treatment, and measures such as inducing vomiting, gastric lavage, or glucose injection may be necessary. Keep the medication out of the reach of children and store it in its original container.

Serious side effects

Hives, severe swelling (edema), difficulty breathing, angioedema, allergic reactions, anaphylaxis, Stevens-Johnson syndrome, severe rashes, blisters, skin peeling, pain in oral/ocular mucosa, liver dysfunction, jaundice, hepatitis, thrombocytopenia, leukopenia, hemolytic anemia, erythrocytopenia, agranulocytosis, pancytopenia, thrombocytopenia with a platelet count below 10,000/μL, and thrombocytopenic purpura.

Mild side effects

Headache, extreme hunger, nausea, vomiting, fatigue, sleep disturbances, anxiety, aggression, decreased concentration, decreased agility or energy, depression, confusion, speech disturbances, aphasia, visual disturbances, tremors, incomplete paralysis, sensory disturbances, dizziness, weakness, loss of self-control, transient mental confusion, drowsiness, bradycardia, sweating, cold and moist skin, tachycardia, hypertension, palpitations, angina, ventricular arrhythmia, blurred vision, fullness or pressure in the upper abdomen.

This medication should be stored in a tightly sealed container to prevent air or moisture from entering. It is best to store it at room temperature between 1 and 30 degrees Celsius.

Appearance

Light blue rectangular tablets

Package unit

30 tablets/bottle, 500 tablets/bottle