Prucalopride 2 mg (Prucalopride Succinate)

Adult dose

This medication is taken orally and can be administered at any time of the day, with or without meals. Adults should take 2 mg once daily. Elderly patients aged 65 years and older start with an initial dose of 1 mg once daily and may be increased to 2 mg once daily if necessary. Patients with severe kidney impairment and severe liver disease should take 1 mg once daily. Patients with mild to moderate kidney or liver impairment do not require dose adjustments.

This medication should not be used by certain patients. For example, individuals allergic to the ingredients or additives of this medication, those with severely impaired kidney function, those with serious problems in their intestines, and those with genetic disorders causing lactose intolerance should not take this medication. For patients with severe kidney damage, the dosage of this medication should be reduced and used cautiously. Additionally, caution should be exercised when administering this medication to patients with serious diseases of the liver, heart, lungs, or nervous system. This medication should also be used carefully in patients with a history of arrhythmia or ischemic heart disease, and it is advisable to reduce the dosage for patients with severe hepatic impairment. Caution is required when taking this medication together with other drugs that can prolong the QT interval. The most commonly reported side effects during treatment with this medication are gastrointestinal symptoms such as headache, abdominal pain, nausea, and diarrhea. These symptoms usually appear early in the treatment and often resolve within a few days. Other reported effects include dizziness, tremors, palpitations, and fatigue. Rarely, abnormal heart rhythms or severe gastrointestinal issues, or neurological problems may also occur, and if severe side effects or new symptoms arise, consultation with a doctor should be sought immediately. In the case of severe diarrhea, the effectiveness of oral contraceptives may decrease, and it is recommended to use additional contraceptive methods. This medication has a low potential for drug interactions, but caution is advisable when taken with certain antifungal agents or cardiology-related drugs. It is also necessary to avoid taking it with anticholinergics that may reduce its effectiveness. The use of this medication is not recommended during pregnancy, and women of childbearing age should use effective contraceptive methods while taking it. Use during breastfeeding is also not recommended. It is advisable not to use this medication in children or adolescents under 18 years of age. Overdose may lead to symptoms such as headache, nausea, and diarrhea, and since there is no specific antidote, treatment should be based on symptoms. If fluid loss due to diarrhea or vomiting is severe, electrolyte supplementation may be necessary. This medication may cause dizziness or fatigue at the beginning of treatment, so caution is advised when driving or operating machinery. Finally, it is important to store this medication out of the reach of children and to keep it in its original container away from moisture.

Serious side effects

• Chest discomfort
• facial swelling
• peripheral edema
• edema

Mild side effects

• Headache
• dizziness
• tremors
• palpitations
• nausea
• diarrhea
• abdominal pain
• vomiting
• indigestion
• rectal bleeding

This medication should be stored in a container that protects it from light and air, and care should be taken to avoid moisture. The recommended storage temperature is room temperature between 1°C and 30°C.

Appearance

Pink round film-coated tablet

Package unit

28 tablets (14 tablets/Alu-Alu x 2)