Cramonex Duo Tablet 500 mg (Amoxicillin - Clavulanate Potassium (7:1))

Adult dose

For adults with severe infections and respiratory infections, take 2 tablets orally, twice daily every 12 hours.

This medication should not be administered to patients with hypersensitivity to beta-lactam antibiotics, including penicillins or cephalosporins. Caution is required as there is an increased risk of rash in patients with viral infections such as infectious mononucleosis or lymphocytic leukemia. Patients who have previously experienced liver dysfunction or jaundice due to this medication or penicillin derivatives are at risk of recurrence, so it is preferable to avoid administration. Patients with impaired liver function may experience further liver dysfunction from drug therapy; therefore, it should be used cautiously. Patients with moderate to severe renal dysfunction may have elevated blood drug concentrations, so dosing intervals should be adjusted accordingly. Patients with allergies or family histories of such conditions should be cautious, as symptoms like bronchial asthma, rash, and urticaria may occur. For patients who cannot take orally or receive non-oral nutrition, the elderly, or those with poor general health, there may be symptoms of vitamin K deficiency, requiring careful observation. Patients experiencing gastrointestinal symptoms like vomiting or diarrhea may not absorb the medication effectively, resulting in reduced efficacy. This medication can cause gastrointestinal side effects such as diarrhea, vomiting, and abdominal pain; in severe cases, membranous colitis or enteritis can occur, necessitating immediate discontinuation upon onset of any unusual symptoms. Liver dysfunction or jaundice may occur, particularly reported more frequently in older males, thus regular liver function tests are important. Rarely, severe skin reactions such as rash, itching, or Stevens-Johnson syndrome may occur; if such symptoms arise, the medication must be discontinued immediately. Hematologic effects may include leukopenia, thrombocytopenia, or anemia, requiring tests if symptoms occur. Central nervous system side effects may include rare occurrences of headache, dizziness, or seizures; the risk of seizures may increase in patients with poor kidney function or those receiving high doses. In patients with renal dysfunction, acute renal failure or interstitial nephritis may develop, necessitating regular kidney function monitoring. Due to antibiotic use, fungal infections like oral or vaginal candidiasis may develop; appropriate treatment is necessary if symptoms appear. There is a tendency for bleeding due to vitamin K deficiency; thus, caution is advised if bleeding symptoms are present. This medication should be administered only for the minimum duration after sensitivity tests to prevent antibiotic resistance. Patients with a history of severe allergic reactions to penicillin derivatives must confirm their allergy history before administration. Anaphylactic shock and other severe allergic reactions are very rarely observed, thus monitoring patients closely post-administration is essential, with emergency treatment ready. Antibiotic-associated membranous colitis may occur, requiring immediate cessation of the drug and appropriate treatment in cases of severe diarrhea or abdominal cramping. Long-term administration may lead to an overgrowth of resistant organisms, necessitating careful monitoring for durations exceeding 14 days. It is advisable to avoid use during pregnancy, particularly in the first trimester, and breastfeeding may cause side effects in infants, requiring discontinuation if unusual symptoms occur. Not recommended for children under 12 years of age or weighing less than 40 kg. Elderly patients may experience adverse reactions more easily due to reduced physiological function; thus, dose and interval adjustments should be done cautiously. This medication may affect certain clinical test results, so it is important to inform healthcare professionals at the time of testing. In cases of overdose, gastrointestinal symptoms, renal failure, and seizures may occur; thus, immediate cessation of the drug and appropriate emergency treatment are warranted.

Serious side effects

Urticaria, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe allergic reactions, severe rash accompanied by high fever, blisters, skin peeling, pain in mucous membranes of mouth/eyes, severe skin reactions, shortness of breath or difficulty breathing, asthma attacks, respiratory changes accompanied by cough and fever, breathing difficulties, yellowing of skin or eyes (jaundice), profound lethargy, liver abnormalities (jaundice), sudden and

Mild side effects

• Diarrhea
• membranous colitis
• indigestion
• stomatitis
• gastritis
• glossitis
• nausea
• vomiting
• loss of appetite
• abdominal pain

This medication may be sensitive to air or moisture; therefore, it must be stored in a tightly sealed container. It should be kept in a cool, dry place at a temperature below 25 degrees Celsius to maintain its effectiveness.

Appearance

White or nearly white oblong film-coated tablet

Package unit

100 tablets - 10 tablets/PTP[X10]