Samsung Meropenem Injection 500 mg (Meropenem Hydrate)

Adult administration

As Meropenem Hydrate, administer 0.5 to 1 g per day (potency) divided into 2 to 3 doses by slow intravenous infusion over at least 30 minutes. For suspected infections in patients with pathogenic pneumonia, peritonitis, and neutropenia, administer 1 g (potency) by slow intravenous infusion every 8 hours. For cystic fibrosis and meningitis, administer 2 g (potency) by slow intravenous infusion every 8 hours.

Child administration

For children over 3 months with bacterial meningitis, administer 40 mg per kg of body weight by slow intravenous infusion over at least 30 minutes every 8 hours, depending on the sensitivity of the pathogen and the patient's condition, as well as the type of infection. Moreover,

This medication should not be used in patients who have previously experienced shock due to this drug or have had allergic reactions to any of its components. Patients currently taking valproate sodium should be cautious as co-administration may decrease valproate blood levels, potentially leading to a seizure recurrence. Patients with a history of severe allergic reactions to other carbapenems or beta-lactam antibiotics should also avoid this drug. Patients with allergic constitutions, a propensity for asthma, rash, or similar symptoms, those with impaired kidney or liver function, those with a history of seizures, elderly patients, and infants under 3 months should be especially cautious when using this medication. This medication may rarely cause hypersensitivity reactions such as shock, anaphylaxis, rash, and urticaria, so if these symptoms occur, use should be discontinued immediately, and medical attention sought. Blood tests may reveal leukopenia, anemia, and platelet changes, so regular monitoring of blood status is necessary. Serious liver and kidney issues like liver function abnormalities or acute renal failure can also occur, necessitating regular tests of liver and kidney function. Gastrointestinal symptoms may include diarrhea, abdominal pain, nausea, and vomiting, with particular caution needed for serious colitis symptoms such as pseudomembranous colitis. Central nervous system symptoms may include seizures and altered consciousness, hence patients with neurological disorders should be extra careful. Respiratory issues such as asthma exacerbation, breathing difficulties, and pneumonia may occur rarely, and symptoms should prompt immediate consultation with a physician. Severe skin reactions such as toxic epidermal necrolysis and Stevens-Johnson syndrome can occur; if skin rashes, red spots, or blisters appear, use should be discontinued immediately. This drug may cause bleeding tendencies associated with vitamin K deficiency, so be alert for bleeding symptoms, and coagulation tests may be necessary. Cardiovascular symptoms reported include heart failure, cardiac arrest, and arrhythmias, so patients with heart diseases should be carefully monitored. Psychoneurological symptoms such as insomnia, confusion, and dizziness may occur, so caution is necessary when driving or operating machinery. This medication may interact with other drugs, so patients taking other medications must inform their doctor or pharmacist. Pregnant or nursing women should only use this drug when absolutely necessary, as its safety during pregnancy has not been established. It is best to avoid it while breastfeeding. The solution must be used promptly after preparation and can only be administered intravenously. When using this medication, appropriate treatment duration and dosage should be determined through sensitivity tests, and prolonged use should be avoided. If adverse reactions arise, use should be discontinued immediately, and consultations with medical professionals should occur.

Serious side effects

• Shock
• anaphylaxis
• hives
• angioedema
• rash
• severe swelling (edema)
• chest tightness
• difficulty breathing
• cold sweat
• pallor

Mild side effects

• Oral discomfort
• wheezing
• dizziness
• changes in stool
• tinnitus
• sweating
• rash
• hives
• a sensation of heat
• erythema

This drug should be stored in a tightly sealed container to avoid exposure to air and kept at room temperature between 1 to 30 degrees Celsius. This helps maintain the drug's effectiveness and prevents deterioration.

Appearance

A crystalline powder that is white to light yellow, contained in a colorless and transparent vial.

Package unit

10 vials/box