Bonvanel Injection (Ibandronic Acid Sodium Hydrate)

Adult administration

An intravenous injection of 3mg is administered once every 3 months over 15-30 seconds. If a dose is missed on the scheduled administration day, inject as soon as possible and continue regular doses at 3-month intervals.

This medication must be administered solely as an intravenous injection, and extreme caution is required as injection into the artery or near the vein can cause tissue damage. It should not be used in patients with allergies to this drug or its components, or in untreated hypocalcemia patients. The use of this drug may cause gastrointestinal-related symptoms such as gastritis, diarrhea, abdominal pain, dyspepsia, nausea, and constipation, as well as symptoms like musculoskeletal pain, arthralgia, and myalgia. Additionally, symptoms similar to influenza such as fever, chills, fatigue, arthralgia, and myalgia may temporarily occur; these symptoms are usually mild and resolve naturally within a short period. Long-term use of this medication can rarely lead to serious side effects such as osteonecrosis of the jaw or bones around the ear, so it is important to thoroughly check oral health before dental treatment. Similar side effects reported include eye inflammation or severe allergic reactions, skin rashes, etc., and if such symptoms occur, immediate medical attention should be sought. This medication can temporarily lower serum calcium levels, so it is necessary to check for hypocalcemia or bone metabolic disorders before administration and ensure adequate intake of calcium and vitamin D. In patients with kidney issues or those on other medications, regular monitoring during treatment is required. The safety of this drug in pregnant or breastfeeding women has not been established, so it is advisable not to use it. In cases of overdose, careful monitoring is needed as it may affect kidney and liver function, and calcium, phosphate, or magnesium supplementation may be necessary. This drug should not be mixed with calcium-containing solutions or other intravenous medications, and used syringes and needles should not be reused but disposed of safely. Finally, the effects of this medication on driving or operating machinery are unknown, so caution is advised.

Serious side effects

Urticaria, angioedema, facial swelling, severe swelling (edema), severe allergic reactions, anaphylaxis, shock, Stevens-Johnson syndrome, erythema multiforme, bullous dermatitis, severe rash with high fever, blisters, skin peeling, oral/ocular mucosal pain, severe skin adverse reactions, difficulty breathing or shortness of breath, asthma attacks, respiratory distress accompanied by cough and fever, dyspnea, liver abnormalities (jaundice), sudden and severe headache

Mild side effects

• Gastritis
• diarrhea
• abdominal pain
• dyspepsia
• nausea
• constipation
• musculoskeletal pain
• arthralgia
• myalgia
• influenza-like illness

This medication should be stored in a sealed container at room temperature between 1 degrees and 30 degrees Celsius. Storing it this way helps maintain the drug's efficacy and prevents deterioration.

Appearance

A colorless and transparent solution in a colorless and transparent glass prefilled syringe with a single-use syringe needle attached.

Package unit

3ml x 1 vial