Hyaluronic Injection (Sodium Hyaluronate)

Adult dosage

As sodium hyaluronate, administer 25mg once a week for 5 consecutive weeks into the knee joint cavity or shoulder joint (shoulder joint cavity, subacromial bursa, or long head of the biceps tendon). Adjust the number of administrations appropriately based on symptoms. This medication must be administered under strict aseptic conditions into the knee joint cavity.

This medication should not be used in individuals with a history of hypersensitivity. In particular, it should not be administered to patients with skin diseases or infections in the joint area. Patients with liver dysfunction or a past history of liver problems should also be cautious. Individuals allergic to avian proteins should refrain from using this medication. When administering this medication, serious allergic reactions such as shock may occur, so the patient should be closely monitored. If symptoms of hypersensitivity such as swelling or redness around the face or eyes, or itching occur, administration should be stopped immediately and appropriate treatment should be sought. Temporary pain, swelling, redness, or warmth may occur at the injection site, so caution is warranted. Other symptoms such as nausea, vomiting, fever, and headache may also occur. In cases of severely inflamed joints, it is advisable to quell the inflammation before administering this medication. After administration, stabilizing the joint and avoiding strenuous exercise is essential. If the medication leaks outside the joint, it may cause pain, so it must be accurately injected at the site. Patients with rheumatoid arthritis or gout arthritis should be cautious as temporary inflammation may worsen. Avoid intense exercise or prolonged weight-bearing within 48 hours post-administration. The safety and efficacy of concomitant use with other intra-articular medications have not been established, so such combinations should be avoided. Pregnant women or those who may become pregnant should use this medication cautiously, and nursing mothers are advised to avoid breastfeeding during treatment. The safety of this medication has not been established in children, so it should be administered cautiously only if necessary. Elderly patients may have decreased physiological functions, so they should use this medication with particular caution. Maintain aseptic conditions during administration and ensure cleanliness at the injection site. If symptoms do not improve, limit administration to a maximum of 5 times and discontinue further use. If fluid builds up in the joint, it is advisable to remove it via aspiration before administration. This medication is not for intra-vascular or ophthalmic use and requires careful selection of syringe needle sizes due to its high viscosity. Shake the ampule to ensure proper mixing of the medication and take care to prevent contamination during cutting. There may be precipitation when mixed with some disinfectants, so caution is needed, and it should be disposed of immediately after single use. It is advisable to administer a local anesthetic before using this medication.

Serious side effects

Shock

Mild side effects

• Swelling (facial, eyelid, etc.)
• facial rashes
• rash
• hives
• itching
• pain
• edema
• redness
• warmth
• severe localized pressure

This medication should be stored in a sealed container to prevent air or moisture from entering, ideally at a temperature between 1 and 30 degrees Celsius. Storing it this way helps maintain the medication's effectiveness and safety.

Appearance

A colorless, transparent viscous solution filled in a glass vial sealed with rubber stoppers at both ends (part of a prefilled syringe system)

Package unit

2.5 milliliters × 10 vials