Megafamsivir Tablets (Famciclovir)

Adult dose

1. Treatment of herpes zoster Adults: Administer famciclovir orally at a dose of 250 mg per dose, 3 times daily for 7 days. It is advisable to start treatment as soon as symptoms appear after infection. 2. Treatment of initial genital herpes infection Adults: Administer this medicine orally at a dose of 250 mg per dose, 3 times daily for 5 days. It is advisable to start treatment as soon as symptoms appear after infection. 3. Treatment of acute recurrent genital herpes infection Adults: Administer this medicine orally at a dose of 125 mg per dose, twice daily for 5 days. It is advisable to start treatment during the prodromal period or as soon as symptoms appear after infection. 4. Suppression of recurrent genital herpes Adults: Administer this medicine orally at a dose of 250 mg per dose, twice daily. Discontinue treatment periodically every 6～12 months to assess whether the natural course of the disease has changed. 5. Patients with renal impairment: Because creatinine clearance of this medicine is decreased in patients with renal impairment, dose adjustment should be undertaken with caution. The dosage and administration for these patients are as follows. 1) Treatment of herpes zoster and initial genital herpes infection: Creatinine clearance (mL/min/1.73㎡) 30～59: 250 mg per dose, twice daily 10～29: 250 mg per dose, once daily 2) Treatment of acute recurrent genital herpes infection: Creatinine clearance (mL/min/1.73㎡) 30～59: 125 mg per dose, twice daily 10～29: 125 mg per dose, once daily 3) Suppression of recurrent genital herpes infection: Creatinine clearance (mL/min/1.73㎡) 30～59: 250 mg per dose, twice daily 10～29: 125 mg per dose, twice daily 4) If only the serum creatinine level is known, creatinine clearance can be calculated using the following formula. Men: {body weight (kg) × (140-age)}/ {72 × serum creatinine (mg/dL)} Women: 0.85 × the value calculated for men 5) Patients with renal impairment undergoing hemodialysis For patients undergoing hemodialysis, it is advisable to administer this medicine every 48 hours, taking the dialysis interval into consideration. Since 4 hours of hemodialysis reduces the plasma concentration of this medicine by approximately 75%, administer this medicine immediately after dialysis. The recommended dose is 250mg for patients with herpes zoster and 125mg for patients with genital herpes. 6. Patients with hepatic impairment: No dose adjustment is necessary for patients with chronic compensated liver disease. There is insufficient treatment experience in patients with overt chronic decompensated liver disease; therefore, a clear recommended dose has not been established.

This medication should not be used in patients who are allergic to certain ingredients or have hereditary lactose metabolism issues. Patients who have allergies to soybean oil, soy, or peanuts should also avoid taking this medicine. Patients with impaired kidney function or issues with fat metabolism should use this medicine with caution, and dosage adjustments may be necessary if needed. This medication can cause side effects such as headache, nausea, dizziness, and drowsiness; in rare cases, symptoms like increased heart rate or skin rash have also been reported. Serious side effects such as liver function abnormalities or acute renal failure may occur, so immediate consultation with healthcare professionals is advised if symptoms appear. Complete treatment of genital herpes cannot be achieved with this medication, thus it is important to avoid sexual contact when symptoms are present and maintain safe sexual practices. If dizziness or drowsiness occurs while taking this medication, avoid driving or operating machinery. Patients with liver or kidney issues should consult with healthcare professionals to determine the appropriate dosage before taking this medicine. This drug may interact with other medications, so be sure to inform your healthcare provider about any other medications you are taking. Pregnant or breastfeeding women must consult with their physician before taking this medication if necessary. Children under the age of 18 should avoid using this medication as its safety and efficacy have not been established. Generally, elderly patients do not require dosage adjustments, but those with decreased kidney function may need dosage modifications. In case of overdose, seek medical attention immediately, and blood dialysis might be helpful. Store this medicine in a dry place below 30 degrees Celsius and keep it out of reach of children. Be careful not to transfer it to another container as this could lead to quality degradation or accidents.

headache

This medicine may be sensitive to air or moisture, so it should be stored in a tightly sealed container. Additionally, it should be kept in a dry place below 30 degrees Celsius to maintain its effectiveness.

Appearance

White, round, film-coated tablet

Package unit

21 tablets/bottle