Medication info
Ciptorin Tablets 10/20 mg

Ciptorin Tablets 10/20 mg

Prescription medicationTablet경구
Ingredient · strength
Ezetimibe›10mg / 1 tabletSimvastatin›20mg / 1 tablet
Manufacturer / importer
에이치엘비제약(주)
Appearance
A white to off-white, bilaterally convex, rectangular tablet
Packaging
30 tablets (10 tablets/PTP X 3)
Approval status
Active

MFDS item code 201900016 · Approved 2019.01.03 · Insurance code 647303590

Summary

Main use
Improvement of cholesterol and lipid levels in hypercholesterolemia (primary, homozygous familial) and mixed hyperlipidemia
Who takes it
Adults
Adult dose
This medication is administered once daily in the evening, regardless of meals. The dosage range for patients with primary hypercholesterolemia is 10/10 mg to 10/40 mg per day, with the generally recommended initial dose being 10/20 mg daily. For patients where there is less need for LDL cholesterol reduction, it may start at 10/10 mg per day. After initiation or dose adjustment, lipid levels should be checked at intervals of 4 weeks or more.

Ingredients

Manufacturer
에이치엘비제약(주)

Efficacy & effects

Improvement of cholesterol and lipid levels in hypercholesterolemia (primary, homozygous familial) and mixed hyperlipidemia

  • Primary hypercholesterolemia
  • heterozygous familial hypercholesterolemia
  • non-familial hypercholesterolemia
  • mixed hyperlipidemia
  • homozygous familial hypercholesterolemia
  • atherosclerotic vascular diseases due to hypercholesterolemia
  • dyslipidemia
View approved original text

This medication helps lower elevated total cholesterol, LDL-cholesterol, apo B protein, and triglycerides in patients with primary hypercholesterolemia and mixed hyperlipidemia, while increasing HDL-cholesterol, the good cholesterol. It is particularly used as an adjunct to other lipid-lowering therapies in patients with homozygous familial hypercholesterolemia, or as an alternate treatment when other therapies are insufficient. This medication should be administered alongside a proper diet, and is used for cases where diet alone cannot effectively control lipid levels. Additionally, it is beneficial as a lipid-regulating medication for patients at high risk of atherosclerotic vascular disease due to hypercholesterolemia. It is crucial to identify and treat underlying causes like diabetes and hypothyroidism before administration if present. This medication is used to improve cholesterol-related lipid levels and reduce the risk of cardiovascular diseases.

How to take

Adult dose

This medication is administered once daily in the evening, regardless of meals. The dosage range for patients with primary hypercholesterolemia is 10/10 mg to 10/40 mg per day, with the generally recommended initial dose being 10/20 mg daily. For patients where there is less need for LDL cholesterol reduction, it may start at 10/10 mg per day. After initiation or dose adjustment, lipid levels should be checked at intervals of 4 weeks or more.

Precautions

This medication is used to lower cholesterol levels in the blood. Muscle pain or weakness may occur during treatment, and if these symptoms develop, immediate consultation with a physician is necessary. Be especially cautious as the risk of muscle problems can increase when taking high doses or certain other medications. This medication may affect liver function, so it should not be taken in patients with liver disease or elevated liver enzyme levels. Moreover, pregnant or breastfeeding women should not take this medication, and those planning to become pregnant should consult a physician. The risk of side effects may increase when taken with medications that inhibit certain enzymes, so any ongoing medications should be fully disclosed to a healthcare provider. Elderly patients or those with impaired kidney function may be more sensitive to side effects, necessitating careful monitoring. Regular liver function tests and muscle-related tests are recommended during administration, and any unusual symptoms should be reported to healthcare professionals immediately. There is no specific antidote in case of overdose, but appropriate treatment based on symptoms is needed. While taking this medication, the intake of certain foods like grapefruit juice should be limited, and attention to drug interactions with other medications is important.

Side effects and when to seek care immediately

Serious side effects

Hives, severe swelling (edema), severe allergic reactions, rash, angioedema, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell syndrome), polymorphic erythema, severe cutaneous adverse reactions, drug reaction with eosinophilia and systemic symptoms (DRESS), myopathy, rhabdomyolysis, increased liver amino transferase levels, hepatitis, pancreatitis, dizziness, paresthesia, depression, drug-induced liver injury

Mild side effects

  • Headache
  • diarrhea
  • influenza
  • upper respiratory infection
  • myalgia
  • limb pain
  • fatigue
  • nausea
  • abdominal pain
  • constipation
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  • upper abdominal pain
  • vomiting
  • chest pain
  • chest discomfort
  • sensory loss
  • nocturia
  • hematuria
  • itching
  • edema
  • thirst
  • facial swelling
  • syncope
  • insomnia
  • gastritis
  • atrophic gastritis
  • dyspepsia
  • mucus stool
  • irritable bowel syndrome
  • sore throat
  • alopecia
  • various skin changes
  • gynecomastia
  • decreased libido
  • erectile dysfunction
  • cataract progression
  • anemia

Not everyone experiences these, and they can vary from person to person.

Storage

This medication is sensitive to air and moisture, so it should be stored in a tightly sealed container. To maintain its effectiveness, it is advisable to store it at room temperature between 1 degree Celsius and 30 degrees Celsius.

Appearance and packaging

Appearance

A white to off-white, bilaterally convex, rectangular tablet

Package unit

30 tablets (10 tablets/PTP X 3)

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

Questions about this medicine

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For anything that needs medical judgment, consult a doctor or pharmacist.

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.