Hepalod Tablet (Tenofovir Disoproxil)

Adult dose

Adults Take 1 tablet (equivalent to 245mg of tenofovir disoproxil) once daily for the treatment of HIV-1 or chronic hepatitis B. It may be taken with or without food. The optimal duration of treatment for chronic hepatitis B is unknown. Patients with renal impairment For patients with a baseline creatinine clearance of <50mL/min, adjust the dosing interval of this medicine according to Table 1. Creatinine clearance 50-80mL/min: No adjustment of the dosing interval is necessary; regularly monitor calculated creatinine clearance and serum phosphorus. Creatinine clearance ≥50mL/min: 1 tablet every 24 hours Creatinine clearance 30-49mL/min: 1 tablet every 48 hours Creatinine clearance 10-29mL/min: 1 tablet every 72-96 hours Patients on hemodialysis: 1 tablet every 7 days or approximately 12 hours after dialysis. Assuming hemodialysis is performed 3 times weekly for approximately 4 hours per session, administer once weekly. This medicine should be administered after dialysis is completed. The pharmacokinetics of tenofovir have not been evaluated in patients with creatinine clearance below 10mL/min who are not receiving hemodialysis; therefore, no dosing recommendations are available for these patients.

Child dose

Children 12 years of age and older (35kg or more) Take 1 tablet (equivalent to 245mg of tenofovir disoproxil) once daily for the treatment of HIV-1 or chronic hepatitis B. It may be taken with or without food. The optimal duration of treatment for chronic hepatitis B is unknown. Pediatric patients with chronic hepatitis B weighing less than 35kg Safety and efficacy have not been established. Pediatric patients with renal impairment No data are available to support dosage recommendations.

This medication is an antiviral drug used for the treatment of hepatitis B. Sudden discontinuation of treatment may worsen hepatitis, so regular liver monitoring must continue for several months after stopping. Patients allergic to this medication or with specific genetic issues such as lactose intolerance should not take it. Also, this medication should not be taken with certain other antiviral agents, as serious side effects may occur with co-administration. Patients with poor kidney function must frequently monitor renal function before and during usage, and if renal function declines significantly, the dosing interval should be adjusted. Caution is needed when taken with other drugs that may burden the kidneys, and alternative treatments should be considered if necessary. It can also affect bone health, so bone density monitoring may be necessary, and immediate consultation with a physician is advised if there is pain in bones or muscles. This medication contains sodium bisulfite, which may cause allergic reactions or asthma symptoms in some patients. During treatment, side effects such as headache, diarrhea, nausea, fatigue, and depression may occur, and severe abnormal symptoms should be reported to healthcare providers immediately. It can generally be used safely during pregnancy, but medical consultation is necessary when administered during pregnancy. Nursing mothers are advised to avoid breastfeeding while taking this medication. Use in children under the age of 12 or weighing less than 35 kg is not recommended due to the lack of established safety and effectiveness. Elderly patients or those with reduced kidney function should exercise particular caution when taking this medication, and dose adjustment may be necessary. In case of overdose, seek medical attention immediately as appropriate treatment should be administered, and blood dialysis may remove the drug. This medication should be stored away from direct sunlight and kept at room temperature, out of reach of children.

• Worsening of hepatitis
• hypersensitivity
• acute kidney failure
• Fanconi syndrome
• renal impairment
• bone pain
• limb pain
• fractures
• muscle pain
• proximal tubular syndrome

This medication should be stored in a tightly sealed container to protect it from air and moisture and must be kept at room temperature between 1 and 30 degrees Celsius. Proper storage ensures the medication's effectiveness.

Appearance

Light blue almond-shaped film-coated tablet

Package unit

30 tablets/bottle