Okodorel Tablets (Clopidogrel Sulfate)

Adult dose

1. For patients with ischemic stroke, myocardial infarction, or peripheral artery disease, 75 mg of clopidogrel is administered orally once daily. 2. For patients with acute coronary syndrome, start with a loading dose of 300 mg orally once on the day of initiation and subsequently administer 75 mg orally once daily as a maintenance dose. Aspirin 75–325 mg should be administered concurrently once daily. 3. For patients with atrial fibrillation,

This medication prevents platelet aggregation in the blood, thus preventing blood clotting. The effectiveness of this medication may be reduced in patients with genetically impaired CYP2C19 enzyme function, so such patients may need to consider changing their treatment or using alternative medications. Additionally, taking this medication with drugs that activate the CYP2C19 enzyme may increase the concentration of the active substance, leading to a higher risk of bleeding, and therefore, concurrent use is not recommended. Patients who are allergic to this medication or its components, patients with bleeding disorders, patients with severe liver damage, breastfeeding women, patients with genetic issues such as lactose intolerance, and those allergic to soybean oil, soybeans, or peanuts should not take this medication. Patients at high risk of bleeding, those with poor liver or kidney function, patients who have recently experienced a stroke, hypertensive patients, and elderly patients should use this medication cautiously and undergo immediate examination when bleeding symptoms are suspected. In particular, patients scheduled for surgery should discontinue this medication 5 to 7 days before the operation and resume after hemostasis is achieved. This medication may cause various adverse reactions, including bleeding, reduction in blood cells, gastrointestinal disturbances, and skin rashes; therefore, consultation with a physician should be sought when abnormal symptoms occur. When taken with other bleeding risk medications, anticoagulants, selective serotonin reuptake inhibitors (SSRIs), non-steroidal anti-inflammatory drugs (NSAIDs), etc., the risk of bleeding may increase, so caution is needed. During pregnancy, the effects on the fetus are unclear, so it should only be used when treatment for severe cardiovascular disease is necessary, and care should be taken during delivery as the risk of bleeding may increase during delivery or neural blockade. Breastfeeding women should consider discontinuing breastfeeding or stopping the medication as it may be excreted in breast milk. The safety and efficacy of this medication in children have not been adequately confirmed, and elderly patients may have an increased risk of bleeding due to declining bodily functions, so caution is needed when taking it. In the case of overdose, bleeding may worsen, and since there are no specific antidotes, treatment should be pursued, such as platelet transfusion, for severe bleeding. This medication should be kept out of reach of children, and transferring it to another container should be avoided as it may affect the quality of the medication.

Serious side effects

Urticaria, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, skin peeling, pain in the mucous membranes of mouth/eyes, shortness of breath or difficulty breathing, asthma attack, respiratory abnormalities with cough + fever, yellowing of the skin or eyes (jaundice), extreme lethargy, sudden and severe headache, thunderclap headache, seizures, confusion, visual disturbances, paralysis, urinary retention

Mild side effects

• Chest pain
• accidental injuries
• influenza-like illness
• pain
• fatigue
• dizziness
• dyspepsia
• diarrhea
• nausea
• headache

This medication is sensitive to air and moisture, so it must be stored in a tightly sealed container. It is recommended to maintain a storage temperature between 1 to 30 degrees Celsius.

Appearance

Pink, round, film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle