Ticagrelor Tablets 90 mg (Ticagrelor)

Adult dose

Do not use this medicine concomitantly with other ADP receptor inhibitors (ticlopidine, clopidogrel, prasugrel). Acute coronary syndrome: Administer a loading dose of 180mg once, followed by 90mg twice daily. Treatment for 12 months is recommended unless discontinuation of this medicine is clinically necessary. Patients taking this medicine should also receive a maintenance dose of aspirin (75 - 150mg), unless specifically contraindicated. Patients with a history of myocardial infarction (occurring at least 1 year previously) and at high risk of thrombotic cardiovascular events: Administer 60mg twice daily. Patients taking this medicine should also receive a maintenance dose of aspirin (75 - 150mg), unless specifically contraindicated. Patients who took 90mg of this medicine or another ADP receptor inhibitor (ticlopidine, clopidogrel, prasugrel) during the first year after myocardial infarction may continue treatment with 60mg of this medicine. Treatment with this medicine may also be initiated in patients within 2 years after myocardial infarction or within 1 year after discontinuation of a previous ADP receptor inhibitor (ticlopidine, clopidogrel, prasugrel). The safety and efficacy of this medicine were evaluated at 3 years of follow-up. Patients with type 2 diabetes who have undergone percutaneous coronary intervention (PCI) for coronary artery disease: Administer 60mg twice daily. Patients taking this medicine should also receive a maintenance dose of aspirin (75 - 150mg), unless specifically contraindicated. For patients with acute coronary syndrome, refer to the corresponding dosage and administration. Data on the safety and efficacy of this medicine for treatment lasting more than 3 years are limited. Patients with acute ischemic stroke or high-risk transient ischemic attack: Administer a loading dose of 180mg once, followed by 90mg twice daily for 30 days. Patients taking this medicine should also receive a maintenance dose of aspirin (75 - 100mg), unless specifically contraindicated. An initial loading dose of aspirin (300-325mg) is recommended for patients with acute ischemic stroke or high-risk transient ischemic attack. This medicine is administered orally and may be taken with or without food. For patients who have difficulty swallowing tablets, crush this medicine into a fine powder, disperse it in half a cup of water, and drink it. Rinse the cup with another half cup of water and drink it. This mixture may also be administered through a nasogastric tube (CH8 or larger); it is important to flush the nasogastric tube with water after administration. When switching from another antiplatelet agent to this medicine, start this medicine 24 hours after the last dose of the previous medicine. If a dose is missed, take only 1 tablet (the next scheduled dose) at the next scheduled dosing time. No dose adjustment is necessary in patients with renal impairment. No dose adjustment is necessary in patients with mild hepatic impairment. This medicine has not been studied in patients with severe hepatic impairment, and experience in patients with moderate hepatic impairment is limited.

Child dose

The safety and efficacy in pediatric patients younger than 18 years have not been established (see “Other”).

This drug prevents blood platelets from aggregating in the bloodstream, reducing the formation of blood clots. However, it may increase the risk of bleeding, so it should not be used in patients with active pathological bleeding or a history of intracranial hemorrhage. If surgery is planned, this medication should be discontinued at least 5 days before the surgery, and if bleeding symptoms occur after surgery, medical consultation should be sought immediately. Patients with an allergy to this drug's components or those with severe liver dysfunction, as well as those taking certain antibiotics or antiviral medications, should not take this drug. Patients at high risk of bleeding or taking other medications that may induce bleeding should use this drug with caution, particularly if they have a history of bleeding disorders, recent trauma or surgery, or gastrointestinal bleeding. Patients with asthma or chronic obstructive pulmonary disease should be especially cautious as respiratory symptoms can occur. Additionally, bradycardia symptoms may occur, so patients with a history of heart disease should consult with their physician. Women who are pregnant or breastfeeding should consult their physician as this medication may pose risks to the fetus or neonate. Elderly patients, those with impaired kidney function, and patients with a history of gout or hyperuricemia should also use this drug with caution. Abruptly discontinuing the drug may increase cardiovascular risks, so it is important to continue taking it as directed by a physician. In cases of overdose, the risk of bleeding may increase, and there is currently no antidote for this medication, so immediate medical attention is necessary. This drug can interact with other medications, so patients are advised to inform their healthcare provider about any other medications they are taking. Lastly, this drug should not be used in children as safety and efficacy have not been established.

Hemorrhage, intracranial hemorrhage, ocular hemorrhage, ear hemorrhage, hypotension, respiratory distress, respiratory tract hemorrhage, gastrointestinal hemorrhage, diarrhea, nausea, dyspepsia, constipation, retroperitoneal hemorrhage, skin hemorrhage, rash, pruritus, muscle hemorrhage, urinary tract hemorrhage, reproductive tract hemorrhage, post-procedural hemorrhage, traumatic hemorrhage, thrombotic thrombocytopenic purpura, bradyarrhythmia, heart block, angioedema, Cheyne-Stokes respiration, central sleep apnea, confusion, dizziness, syncope, headache, vertigo, ear hemorrhage, elevated serum creatinine, hyperuricemia, gout, chest pain, cough, pulmonary hemorrhage, pharyngitis, upper respiratory tract infection, asthma, pleural effusion, bronchitis, pneumothorax, pneumonia, pulmonary edema, weakness, anaphylactic shock, epistaxis, hemoptysis, hematoma, cerebral hemorrhage, spinal stenosis, dementia, migraine, paralysis, gait abnormality, rectal bleeding, anal bleeding, appendicitis, tendinitis, bursitis, rhabdomyolysis, hepatitis, snoring, aneurysm, heart failure, cardiac dysrhythmia, palpitations, ventricular tachycardia, arrhythmia, ventricular fibrillation, cardiac arrest, ventricular fibrillation, urinary tract infection, kidney stones, cerebral ischemia, venous stenosis, cerebral infarction, arterial stenosis, angina pectoris, coronary thrombosis, myocardial ischemia, fungal infection, anemia, vestibular disorder, malignant neoplasm of male genital organs, chemical poisoning, post-procedural hematoma, laceration, traffic accident, trauma, nausea, vomiting, acute renal failure, melena, gastrointestinal bleeding, increased sputum, sleep apnea, pulmonary congestion, oral edema, influenza-like illness, tuberculosis infection, high temperature, unspecified hernia, breathlessness, generalized edema, thrombosis, deep vein thrombosis, cardiac thrombus, coagulopathy, thrombocytosis, speech disorder, cerebral hypoxia, scalp tenderness, peripheral neuropathy, cervical rigidity, vocal cord dysfunction, seizure, neuropathy, neuralgia, movement disorder, tremor, lower limb paralysis, coma, sensory loss, oral pain, gastroenteritis, belching, irritable bowel syndrome, stomatitis, ulcerative stomatitis, benign gastrointestinal neoplasm, dental disease, tongue disease, tenosynovitis, arthrosis, chondrocalcinosis, spondyloarthritis, arthritis, contact dermatitis, fungal dermatitis, skin disease, erythematous rash, keratosis, acute urticaria, onychomycosis, hair loss, scleroderma, dermatofibroma, increased sweating, hyperlipidemia, hypertriglyceridemia, worsening of diabetes, hypercholesterolemia, lipodystrophy, dehydration, thirst, hepatitis, cholelithiasis, gallbladder disease, increased alkaline phosphatase, fatty liver, drowsiness, neurosis, depression, hallucination, memory disturbance, erectile dysfunction, anxiety, palpitations, bradycardia, tinnitus, ear pain

This medication can be sensitive to air or moisture; therefore, it must be stored in a tightly sealed container. It is also important to store the medication at room temperature, between 1 and 30 degrees Celsius, to ensure its effectiveness.

Appearance

Yellow, bi-convex, round film-coated tablet

Package unit

56 tablets (14 tablets/PTP × 4/1 box), 10 tablets/PTP