Cospenem Injection 500 mg (Meropenem Hydrate)

Adult dosage

As meropenem hydrate, administer 0.5 to 1 g (potency) daily divided into 2 to 3 times by intravenous infusion over more than 30 minutes. For suspected infections in patients with pathogenic pneumonia, peritonitis, and neutropenia, administer 1 g (potency) by intravenous infusion every 8 hours. For cystic fibrosis and meningitis, administer 2 g (potency) by intravenous infusion every 8 hours.

Children's dosage

For bacterial meningitis in children over 3 months, administer by intermittent intravenous infusion at a dose of 40 mg per kg of body weight every 8 hours, infused over more than 30 minutes, depending on the susceptibility of the pathogen and the patient's condition.

This medication should not be administered to certain patients under any circumstances. For example, individuals who have previously experienced shock from this medication, those taking valproate sodium, individuals with allergies to this medication or its components, and those who have had severe allergic reactions to other carbapenems or beta-lactam antibiotics should not use this medication. Additionally, individuals who are allergic or have impaired kidney function, those with epilepsy or central nervous system diseases, patients with severe liver dysfunction, elderly patients, and infants (especially those under 3 months of age) should use this medication with caution. These individuals may risk increased drug concentration leading to side effects, so dosage adjustment or administration interval adjustment is necessary. Serious allergic reactions such as shock or anaphylaxis may rarely occur when using this medication, so the patient's condition should be closely monitored before and after administration. If allergic symptoms such as skin rash, hives, itching, or fever occur, administration should be stopped immediately, and appropriate treatment should be sought. Abnormal results may appear in blood tests, especially decreases in blood cell counts, anemia, liver function abnormalities, and kidney function impairments, thus requiring regular tests. Gastrointestinal symptoms such as abdominal pain, severe diarrhea, nausea, or vomiting should also be monitored closely. Central nervous system symptoms such as seizures or consciousness disturbances may occur, so extra caution should be taken in patients with kidney or central nervous system diseases. Respiratory abnormalities, severe skin reactions, signs of vitamin deficiency, and cardiovascular symptoms may also occur rarely, so any unusual symptoms should be discussed with medical personnel immediately. This medication should only be used for the necessary minimum duration to prevent the emergence of resistant bacteria, and it is important to confirm its effectiveness through susceptibility tests before and during administration. Additionally, there are medications that interact with this drug, so follow professionals' instructions when used concurrently. Women who are pregnant or may become pregnant should use this medication cautiously, as its safety has not been established, and only if the benefits outweigh the risks. If breastfeeding, it is recommended to avoid this medication as it may be excreted in breast milk. Elderly patients may experience side effects more easily due to decreased bodily function, so dosage and administration intervals should be adjusted while monitoring their condition closely. Finally, this medication is used solely as an intravenous injection, and once dissolved, it should be used as soon as possible. The color change of the solution does not affect its efficacy, but it is safer to use it within the specified time when stored.

Serious side effects

Shock, anaphylactic-like reactions, severe allergic reactions, severe skin reactions (toxic epidermal necrolysis, Stevens-Johnson syndrome, erythema multiforme, acute generalized exanthematous pustulosis, etc.), fulminant hepatitis, hepatic failure, jaundice, acute renal failure, severe kidney impairment, pseudomembranous colitis, severe colitis, seizures, impaired consciousness, central nervous system symptoms, asthma, dyspnea, interstitial pneumonia, pulmonary edema, PIE syndrome, peripheral edema, heart failure, cardiac arrest, hyperkalemia.

Mild side effects

• Rash
• hives
• warmth
• redness
• itching
• fever
• flushing
• angioedema
• oral abnormalities
• wheezing

This medication should be stored in a sealed container to prevent exposure to air, and it is safely stored at room temperature between 1 and 30 degrees Celsius. This storage method maintains the medication's efficacy and prevents degradation.

Appearance

A colorless and transparent vial filled with white to light yellow crystalline powder.

Package unit

10 vials